Results 181 to 190 of about 161,875 (242)

Emerging Target Discovery Strategies Drive the Decoding of Therapeutic Power of Natural Products and Further Drug Development: A Case Study of Celastrol

Exploration, EarlyView.
Using celastrol as a case study, this review summarizes various target discovery strategies for natural products, including chemical proteomics, protein microarray, degradation‐based protein profiling, proteome‐wide label‐free approaches, network pharmacology, target‐based drug screening, and indirect strategies.
Yanbei Tu, Guiyu Dai, Yanyan Chen, Lihua Tan, Hanqing Liu, Meiwan Chen   +5 more
wiley   +1 more source

Endocrine manifestations and long-term outcomes of patients with mitochondrial diseases. [PDF]

Orphanet J Rare Dis
Kim JH, Kim D, Hwang S, Kim GH, Lee BH, Yoo HW, Choi JH.   +6 more
europepmc   +1 more source

Controlled Ascent Rate Enhances Autophagy and Mitigates Acute Lung Injury in Rats Exposed to High‐Altitude Hypoxia by Inhibiting Oxidative Stress and Inflammation

Global Challenges, EarlyView.
This study explores how gradual ascent rates reduce acute pulmonary injury in rats exposed to high‐altitude hypoxia by activating autophagy and suppressing oxidative stress and inflammation. Results show that controlled ascent effectively mitigates such injury, highlighting its potential as a preventive strategy.
Kairui Huang, Wenhui Shi, Jiajia Li, Xiaoyan Ma, Jiangwei Liu   +4 more
wiley   +1 more source

Hydroxycotinine exhibits a stronger association with chronic kidney disease in smokers when compared to cotinine: Evidence from NHANES 2013-2018. [PDF]

Tob Induc Dis
Zhao S, Zheng S, Liu Z, Xu Y, Jia N, Lu C, Wang Y.   +6 more
europepmc   +1 more source

Prognostic Factors for Free Flap Failure in Head and Neck Reconstruction

Head &Neck, EarlyView.
ABSTRACT Background The failure rate of free flaps varies from 0.8% to 10.6% in the literature in head and neck reconstruction. The primary objective was to identify prognostic factors for free flap failure. Methods We prospectively included all consecutive free flaps performed between August 2021 and January 2024, and used a multivariate Cox ...
Quentin Hennocq, Jean‐Baptiste Caruhel, Mourad Benassarou, Jebrane Bouaoud, André Chaine, Angélique Girod, Nicolas Graillon, Sylvie Testelin, Mélika Amor‐Sahli, Jean‐Philippe Foy, Chloé Bertolus   +10 more
wiley   +1 more source

A nomogram for predicting mortality risk in geriatric patients with hip fractures complicated by pneumonia: A multicenter study. [PDF]

SAGE Open Med
Zhang K, Li X, Xiao Y, Zhou C, Liu Y, Zhen F, Zhang H, Nie M.   +7 more
europepmc   +1 more source

Preoperative Vitamin D Supplementation to Reduce Hypocalcemia Following Total Thyroidectomy: Systematic Review and Meta‐Analysis of Randomized Clinical Trials

Head &Neck, EarlyView.
ABSTRACT Objective This study aims to determine whether preoperative supplementation of vitamin D reduces the incidence of hypocalcemia following total thyroidectomy. Methods Conducted in conformity with the PRISMA statement, a systematic review and meta‐analysis of randomized clinical trials (RCT) was performed assessing postoperative hypocalcemia and
Luca Canali, Gian Marco Pace, Marika D. Russell, Francesca Gaino, Luca Malvezzi, Gherardo Mazziotti, Andrea Lania, Giuseppe Spriano, Michael Mannstadt, Gregory W. Randolph, Giuseppe Mercante   +10 more
wiley   +1 more source

Navigating Diagnostic Delays: A Case of Takayasu Arteritis Complicated by Acute Heart Failure and Vascular Compromise in a 37-Year-Old Woman From Cameroon. [PDF]

Cureus
Edmond Asongtia T, Gerald Fomekong T, Jervis Somo L, Saapi Ghislain F, Irene KFB.   +4 more
europepmc   +1 more source

Washington University Medical Alumni Quarterly, July 1951 [PDF]

, 1951

core   +1 more source