Results 221 to 230 of about 172,875 (307)

Effectiveness and safety of combining thiazides with loop diuretics vs. loop diuretics monotherapy in patients with acute decompensated heart failure: A retrospective cohort study

open access: yesBritish Journal of Clinical Pharmacology, EarlyView.
Aims This study investigated factors associated with and outcomes of combined loop diuretics with hydrochlorothiazide (HCTZ) for acute decompensated heart failure (ADHF). Methods In this retrospective study, adults hospitalized for ADHF and who received intravenous loop diuretics between January 2016 and March 2023 were enrolled.
Chia‐Chen Hsu   +6 more
wiley   +1 more source

Renal function after conversion from cyclosporine to FK 506 in liver transplant patients [PDF]

open access: yes, 1991
Brown, H   +6 more
core  

Why and how do we perform physical examination(s) in clinical trials? A use case of drug intervention trials in type 2 diabetes mellitus

open access: yesBritish Journal of Clinical Pharmacology, EarlyView.
Aims The aim of this study was to determine the purpose and use of physical examination (PE) in phase 3 and 4 drug interventional clinical trials within type 2 diabetes mellitus. Methods A total of 226 clinical trial protocols identified from the ClinicalTrials.gov database were systematically reviewed by five researchers.
Julia Kopanz   +9 more
wiley   +1 more source

The Effect of α‐Mangostin on the Pharmacokinetic Profile of Tofacitinib in Rats Both In Vitro and In Vivo

open access: yesBiopharmaceutics &Drug Disposition, EarlyView.
α‐mangostin (α‐MG) significantly affected tofacitinib metabolism by competing for the same site in CYP3A4. Co‐administration of these two medicines poses a potential herb–drug interaction. ABSTRACT This study investigated the effects of α‐mangostin (α‐MG) on the pharmacokinetics of tofacitinib in vitro and in vivo, aiming to recommend its appropriate ...
Jiange Yao   +6 more
wiley   +1 more source

Engineering antibodies with cancer‐associated binding sites

open access: yesBMEMat, EarlyView.
This review describes antibodies that perform direct/indirect roles in cancer treatment by binding to effective targets and discusses how antibodies kill tumors and modulate tumor microenvironment through these targets. The classification of expression systems for antibody production is summarized to guide appropriate selection based on different ...
Yinqi Tian   +4 more
wiley   +1 more source

The impact of remdesivir on renal and liver functions in severe COVID-19 patients with presence of viral load. [PDF]

open access: yesSci Rep
Waldauf P   +14 more
europepmc   +1 more source

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