Results 41 to 50 of about 454,038 (355)

Persistent High Serum Bicarbonate and the Risk of Heart Failure in Patients With Chronic Kidney Disease (CKD): A Report From the Chronic Renal Insufficiency Cohort (CRIC) Study

Journal of the American Heart Association : Cardiovascular and Cerebrovascular Disease, 2015
Background Serum bicarbonate varies over time in chronic kidney disease (CKD) patients, and this variability may portend poor cardiovascular outcomes. The aim of this study was to conduct a time‐updated longitudinal analysis to evaluate the association ...
M. Dobre, Wei Yang, Q. Pan, L. Appel, K. Bellovich, J. Chen, H. Feldman, Michael J. Fischer, L. Ham, T. Hostetter, B. Jaar, Radhakrishna R. Kallem, S. Rosas, J. Scialla, M. Wolf, Mahboob Rahman   +15 more
semanticscholar   +1 more source

Use of Antihypertensive Agents and Association With Risk of Adverse Outcomes in Chronic Kidney Disease: Focus on Angiotensin-Converting Enzyme Inhibitors and Angiotensin Receptor Blockers. [PDF]

, 2018
Background Our objective was to determine patterns of antihypertensive agent use by stage of chronic kidney disease (CKD) and to evaluate the association between different classes of antihypertensive agents with nonrenal outcomes, especially in advanced ...
Johansen, Kirsten L, Ku, Elaine, Lin, Feng, McCulloch, Charles E, Vittinghoff, Eric   +4 more
core  

YAP1::TFE3 mediates endothelial‐to‐mesenchymal plasticity in epithelioid hemangioendothelioma

Molecular Oncology, EarlyView.
The YAP1::TFE3 fusion protein drives endothelial‐to‐mesenchymal transition (EndMT) plasticity, resulting in the loss of endothelial characteristics and gain of mesenchymal‐like properties, including resistance to anoikis, increased migratory capacity, and loss of contact growth inhibition in endothelial cells.
Ant Murphy, Samuel Hartzler, Paula A. Vargas Carranza, Shyaman Jayasundara, Madison E. Yates, Nimod D. Janson, Bozhi Liu, Annaleigh Benton, Majid Kazemian, Jason A. Hanna   +9 more
wiley   +1 more source

Long-term prevention of renal insufficiency, excess matrix gene expression, and glomerular mesangial matrix expansion by treatment with monoclonal antitransforming growth factor-ß antibody in \u3ci\u3edb/db\u3c/i\u3e diabetic mice [PDF]

, 2000
Emerging evidence suggests that transforming growth factor-(TGF-β) is an important mediator of diabetic nephropathy. We showed previously that short-term treatment with a neutralizing monoclonal anti-TGF-antibody (αT) in streptozotocin-diabetic mice ...
Chen, Sheldon, Han, Dong Cheol, Hoffman, Brenda B., Hong, Soon Won, Iglesias-de la Cruz, M. Carmen, Isono, Motohide, McGowan, Tracy A., Sharma, Kumar, Ziyadeh, Fuad N.   +8 more
core   +1 more source

PYCR1 inhibition in bone marrow stromal cells enhances bortezomib sensitivity in multiple myeloma cells by altering their metabolism

Molecular Oncology, EarlyView.
This study investigated how PYCR1 inhibition in bone marrow stromal cells (BMSCs) indirectly affects multiple myeloma (MM) cell metabolism and viability. Culturing MM cells in conditioned medium from PYCR1‐silenced BMSCs impaired oxidative phosphorylation and increased sensitivity to bortezomib.
Inge Oudaert, Lauren van den Broecke, Osman Aksoy, Judith Lind, Sonia Vallet, Arne Van der Vreken, Gamze Ates, Ann Massie, Ken Maes, Kim De Veirman, Elke De Bruyne, Karin Vanderkerken, Klaus Podar, Eline Menu   +13 more
wiley   +1 more source

High Fat High Cholesterol Diet (Western Diet) Aggravates Atherosclerosis, Hyperglycemia and Renal Failure in Nephrectomized LDL Receptor Knockout Mice: Role of Intestine Derived Lipopolysaccharide.

PLoS ONE, 2015
A high fat meal, frequently known as western diet (WD), exacerbates atherosclerosis and diabetes. Both these diseases are frequently associated with renal failure.
Siddhartha S Ghosh, Samuel Righi, Richard Krieg, Le Kang, Daniel Carl, Jing Wang, H Davis Massey, Domenic A Sica, Todd W B Gehr, Shobha Ghosh   +9 more
doaj   +1 more source

The role of chemokine genes in the formation of terminal stage of chronic renal failure [PDF]

, 2018
The data on the role of chemokine genes (+1931A/T CCL4, A/G CXCL11 (rs4512021), -403A/G CCL5, C/G CCL2 (rs2857657), -801G/A CXCL12) in the formation of terminal stage of chronic renal failure, in patients with chronic glomerulonephritis, is presented in ...
Efremova, O. A., Evdokimov, V. I., Nekipelova, E. V., Novakova, O. N., Yakunchenko, T. I.   +4 more
core  

Overview of molecular signatures of senescence and associated resources: pros and cons

FEBS Open Bio, EarlyView.
Cells can enter a stress response state termed cellular senescence that is involved in various diseases and aging. Detecting these cells is challenging due to the lack of universal biomarkers. This review presents the current state of senescence identification, from biomarkers to molecular signatures, compares tools and approaches, and highlights ...
Orestis A. Ntintas, Sylvia Vagena, Pavlos Pantelis, Giorgos Theocharous, Russel Petty, Konstantinos Evangelou, Vassilis G. Gorgoulis   +6 more
wiley   +1 more source

A rare presentation of the Klinefelter's syndrome [PDF]

, 2003
A 16 years old boy with Chronic Renal Failure (CRF) was not suspected of having Klinefelter's syndrome until he complained of painful gynecomastia. He was under haemodialysis for 2 years. At first, he was in an approximately full pubertal development (P5,
A. Frank, B. Rothschild, B.M. Maggs, F. Shahrokhi, G. Calinescu, H. Okamura, K. Kuratowski, L.R. Ford, M. Charikar, M.V. Lomonosov, N. Garg, N. Robertson, O. Günlük, P. Elias, P. Klein, P. Seymour, P.D. Seymour, P.N. Klein, S. Rao, S.N. Bhatt, T. Hu, T. Leighton, Y. Aumann, É. Tardos   +23 more
core   +2 more sources

Delayed Puberty and Its Association With Hormonal Changes in Children With Chronic Renal Insufficiency

Acta Medica Iranica, 2022
Chronic kidney diseases affect sex hormones, and thus it is now hypothesized abnormal puberty phenomenon in adolescents suffering renal failure. The primary study endpoint was to assess the frequency of disorders related to the clinical incidence of ...
Davood Amirkashani, Nakisa Hooman, Mohaddese Shahidzadeh   +2 more
doaj   +1 more source