Results 81 to 90 of about 2,481,937 (240)
Hypoglycemic therapy in patients on hemodialysis and peritoneal dialysis
Сахарный диабет, 2010 Diabetes mellitus (DM) is a leading cause of renal insufficiency in developed countries. Most cases of chronic renal disease in DM patients are dueto diabetic nephropathy.
Irina Arkad'evna Bondar' +1 more
doaj +1 more source
Chronic Renal Insufficiency in an Adolescent Male with Bilateral Urolithiasis: A Case Report
, 2004 The rare case of a 15-year-old male adolescent with chronic renal insufficiency, bilateral hydronephrosis, and urolithiasis, is presented. Characteristic features included abdominal mass, delayed presentation, marked growth retardation and profound ...
Marchie, T +5 more
core +1 more source
Advanced Science, EarlyView.Amphiphilic sulfonated chitosan nanoparticles buffer endo/lysosomal acidity in microglia by limiting V‐ATPase membrane recruitment and restoring endosomal homeostasis. Following systemic administration, they accumulate in the ischemic hemisphere partly through association with infiltrating immune cells, suppress TLR3/IRF3 and TLR4/NF‐κB signaling ...
Xuanlin Wang +4 more
wiley +1 more source
Epidemiological clinical characterization of patients with advanced chronic kidney disease
Acta Médica del Centro, 2016 Chronic kidney disease is considered as one of the major epidemics of the XXI century and provides a significant burden of morbidity and mortality in the world; it is important to identify and modify the factors of risk that influence its progression. In
Lexis Caridad Ramírez Felipe +3 more
doaj
BMC NephrologyBackground The primary aim of this study is to explore the relationship between serum levels of LOX-1, hs-cTnT, and NGAL, and renal function in patients with CKD, as well as to evaluate their diagnostic value for early detection and monitoring of disease
Liyin Chai +7 more
doaj +1 more source
Renal AA-amyloidosis in intravenous drug users - a role for HIV-infection? [PDF]
, 2012 Background: Chronic renal disease is a serious complication of long-term intravenous drug use (IVDU). Recent reports have postulated a changing pattern of underlying nephropathy over the last decades.
Grützmacher, Peter +17 more
core +2 more sources
Advanced Science, EarlyView.In human CAVD, KLF5 is reduced in VIC‐rich regions and remodeling/stress‐associated VIC states. In VICs, KLF5 sustains BNIP3 promoter activity and BNIP3‐mediated mitophagy, thereby limiting cytosolic mtDNA accumulation. KLF5 loss weakens mitochondrial quality control and enhances mtDNA‐sensitive STING/NF‐κB/NLRP3 inflammatory signaling under osteogenic
Jin‐Hui Bian +13 more
wiley +1 more source
D-dimer to Rule Out Pulmonary Embolism in Renal Insufficiency [PDF]
, 2014 BACKGROUND D-dimer levels are often elevated in renal insufficiency. The diagnostic accuracy of D-dimer to rule out pulmonary embolism in patients with renal insufficiency is unclear.
Lindner, Gregor +15 more
core +1 more source
Advanced Science, EarlyView.Integrative multi‐cohort analyses identify 14‐3‐3γ as a biomarker and regulator of cognitive vulnerability. Experimental studies show that 14‐3‐3γ loss is associated with Tau Thr205 phosphorylation, synaptic dysfunction, and cognitive impairment, while genetic overexpression or pharmacological stabilization of 14‐3‐3γ confers protective effects in ...
Shouqiang Zhu +5 more
wiley +1 more source
FOXP1 Knockdown Reprograms Th9 CAR‐T Cells to Overcome Antigen Escape
Advanced Science, EarlyView.FOXP1 knockdown enhances Th9 CAR‐T cell function by promoting IL‐9 production, effector activation, and reduced exhaustion. Reprogrammed Th9 CAR‐T cells strengthen direct tumor killing and activate endogenous antitumor immunity through dendritic cells and CD8+ T cells, thereby suppressing both antigen‐positive and antigen‐loss tumor growth and ...
Yihan Zhu +14 more
wiley +1 more source