Results 111 to 120 of about 288,448 (309)

Restricted Crystalloid Fluid Therapy during Orthotopic Liver Transplant Surgery and its Effect on Respiratory and Renal Insufficiency in the Early Post-operative Period: A Randomized Clinical Trial

open access: yesInternational Journal of Organ Transplantation Medicine, 2014
Background: Respiratory and renal insufficiencies are common dysfunctions during post-liver transplantation period that increase post-operative mortality and morbidity rates.
MA Sahmeddini   +6 more
doaj  

Herpes zoster after left nephroureterectomy for renal carcinoma: a case report

open access: yesBMC Infectious Diseases
Background Diabetes and malignant tumors often lead to abnormal immune function, increasing susceptibility to herpes zoster and severe post-herpetic neuralgia. Renal insufficiency following renal cell carcinoma surgery can be compounded by treatment with
Yuren Zhang, Jie Li, Qing Ni
doaj   +1 more source

Sex‐Specific Regulation of Glycemic Homeostasis by Theabrownin from Pu‐erh Tea

open access: yesAdvanced Science, EarlyView.
Pu‐erh tea's key component, theabrownin (TB), lowers blood glucose in a sex‐specific manner. In females, estrogen boosts intestinal MUC2 production, which dramatically enhances TB's ability to inhibit the carbohydrate‐digesting enzyme α‐glucosidase.
Yang Li   +22 more
wiley   +1 more source

Mitochondria and Neuromast Tagging With Fluorescent Gallium‐Triapine Analogues: In Cellulo MP FLIM and Zebrafish Live Imaging

open access: yesAdvanced Science, EarlyView.
Fluorescent BODIPY‐conjugated thiosemicarbazone ligands and their Ga(III), In(III), and Fe(III) complexes, inspired by Triapine, are developed as theranostic agents. Multiphoton FLIM and confocal microscopy in cancer cells and zebrafish reveal real‐time uptake, mitochondrial localisation, and whilst spectroscopic assays indicated preserved complex ...
Megan J. Green   +15 more
wiley   +1 more source

GloPath: An Entity‐Centric Foundation Model for Glomerular Lesion Assessment and Clinicopathological Insights

open access: yesAdvanced Science, EarlyView.
An entity‐centric foundation model, GloPath, is introduced for comprehensive glomerular lesion assessment from routine renal biopsy images. Trained on over one million glomeruli, the framework enables robust lesion recognition, grading, and cross modality diag nosis, while uncovering large‐scale clinicopathological associations.
Qiming He   +28 more
wiley   +1 more source

T Cell Exhaustion in Cancer Immunotherapy: Heterogeneity, Mechanisms, and Therapeutic Opportunities

open access: yesAdvanced Science, EarlyView.
T cell exhaustion limits immunotherapy efficacy. This article delineates its progression from stem‐like to terminally exhausted states, governed by persistent antigen, transcription factors, epigenetics, and metabolism. It maps the exhaustion landscape in the TME and proposes integrated reversal strategies, providing a translational roadmap to overcome
Yang Yu   +7 more
wiley   +1 more source

The relationship between serum levels of LOX-1, hs-cTnT, NGAL, and renal function, and their diagnostic value in patients with chronic kidney disease: a retrospective study

open access: yesBMC Nephrology
Background The primary aim of this study is to explore the relationship between serum levels of LOX-1, hs-cTnT, and NGAL, and renal function in patients with CKD, as well as to evaluate their diagnostic value for early detection and monitoring of disease
Liyin Chai   +7 more
doaj   +1 more source

Integrating Spatial Proteogenomics in Cancer Research

open access: yesAdvanced Science, EarlyView.
Xx xx. ABSTRACT Background: Spatial proteogenomics marks a paradigm shift in oncology by integrating molecular analysis with spatial information from both spatial proteomics and other data modalities (e.g., spatial transcriptomics), thereby unveiling tumor heterogeneity and dynamic changes in the microenvironment.
Yida Wang   +13 more
wiley   +1 more source

Pre-eclampsia toxaemia [PDF]

open access: yes, 2013
A 33 year old primagravida rhesus positive woman was referred to the Emergency Department by her family doctor at 27 weeks gestation. At 25 weeks of gestation, she had been diagnosed with hypertension and was started on labetalol therapy.
Bugeja, Roberta, Galdes, Caroline
core  

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