Results 91 to 100 of about 885,585 (253)

Reversing Macrophage Immunometabolic Dysfunction in Prolonged Infections Via a Glutaminolysis‐Fueled Restoration‐Based Hierarchically Selective Therapeutic System

Advanced Science, EarlyView.
A hierarchically selective immunotherapeutic nanoplatform, mGls@HEV‐MTP, selectively restores macrophage immunocompetence through GLS1‐mediated restoration of glutaminolysis‐fueled anaplerosis. Concurrently, it renders Staphylococcus aureus (S. aureus) more readily recognizable to the metabolically reprogrammed macrophages, thereby facilitating ...
Weinan Yang, Zihao An, Honglu Cai, Congsun Li, Jiaxuan Zou, Wushi Cui, Wentao Chen, Tao Zhang, Shicheng Wang, Zizhan Su, Jian Xiao, Tao Sun, Bin Hu, Min Cheng, Zhongru Gou, Jianbin Xu, An Liu, Haobo Wu   +17 more
wiley   +1 more source

The Association among Corneal Nerve Metrics, Ocular Surface Integrity, and Renal Function in Type 2 Diabetes

Ophthalmology Science
Purpose: To investigate the association among corneal nerves, ocular surface, and renal function in diabetes, and to compare these variables in patients with and without chronic diabetic kidney disease (DKD). Design: Cross-sectional study.
Chang Liu, MD, Hong Chang Tan, MBBS, PhD, Mingyi Yu, MD, Isabelle Xin Yu Lee, MSc, Ching-Yu Cheng, MD, PhD, Yu-Chi Liu, MD, PhD   +5 more
doaj   +1 more source

Renal sympathetic denervation for treatment of resistant hypertension – Indigenous technique

Indian Heart Journal, 2013
Background: The endovascular approach of ablation of renal sympathetic nerves is found to be effective in the treatment of uncontrolled hypertension.
Gajendra Manakshe, R. Chakravarthi, Shaista Hussaini, Rajeev Menon, A. Srinivas Kumar, V. Ravi Kiran, Gomathi Sundar, C. Narasimhan   +7 more
doaj   +1 more source

Restoring Endothelial Mitochondrial Homeostasis With a Bioactive Nanoshield Promotes Vascular Regeneration on Cardiovascular Implants

Advanced Science, EarlyView.
A bioactive poly(citrate‐polyglycol‐procyanidin) (PCGP) nanoshield is developed for cardiovascular implants to restore endothelial mitochondrial homeostasis following vascular injury. By preserving mitochondrial integrity, re‐establishing metabolic balance, and activating PI3K/Akt/eNOS‐NO signaling, the PCGP interface promotes functional endothelial ...
Xiyu Liu, Wen Zhang, Lunxin Liu, Lan Gui, Yumei Qin, Xiaohui Yang, Longjian Zhang, Chaohua Wang, Jinpeng Hu, Gaoyang Guo, Qing Jiang, Jin Wang, Li Yang, Bo Zhang, Yunbing Wang   +14 more
wiley   +1 more source

Low-level neurostimulation of the renal nerves as a potential therapeutic strategy for hypertension treatment

Frontiers in Pharmacology
BackgroundNeurostimulation is an emerging treatment for conditions like hypertension. The renal nerves, comprising sensory afferent and sympathetic efferent fibers, are crucial for blood pressure (BP) regulation.
Ibrahim M. Salman, Omar Z. Ameer, Sarah F. Hassan, Arun Sridhar, Yee-Hsee Hsieh, Stephen J. Lewis, Stephen J. Lewis   +6 more
doaj   +1 more source

Evidence that blood pressure remains under the control of arterial baroreceptors in renal hypertensive rats

Brazilian Journal of Medical and Biological Research, 2009
The purpose of the present study was to determine the range of the influence of the baroreflex on blood pressure in chronic renal hypertensive rats. Supramaximal electrical stimulation of the aortic depressor nerve and section of the baroreceptor nerves (
A.S. Trindade Jr., E.D. Moreira, G.J.J. Silva, E.M. Krieger   +3 more
doaj   +1 more source

Renal sensory nerves increase sympathetic nerve activity and blood pressure in 2-Kidney 1-Clip hypertensive mice [PDF]

, 2020
Renal denervation lowers arterial blood pressure (ABP) in multiple clinical trials and some experimental models of hypertension. These antihypertensive effects have been attributed to the removal of renal afferent nerves. The purpose of the present study
Ong, Jason
core  

Lyssavirus Nucleoprotein Induces GPAT4‐Mediated CYB5R1 Depalmitoylation to Suppress Ferroptosis and Promote Viral Replication

Advanced Science, EarlyView.
Lipid metabolism plays a vital role in viral infections. Here, we reveal that the lyssavirus N protein regulates GPAT4 to induce lipid droplet biogenesis, restricting CYB5R1 palmitoylation and reducing ferroptosis susceptibility to ultimately promote viral replication.
Jianqing Zhao, Chuan Liang, Pingping Chen, Meixin Sun, Zhen F. Fu, Ling Zhao, Ming Zhou   +6 more
wiley   +1 more source

Preclinical Evaluation of a Novel Cryo Renal Denervation System

JACC: Basic to Translational Science
Summary: The objective of this study was to demonstrate the safety and efficacy of a novel cryo renal denervation system (Cryo-RDN) in a porcine model. Procedural and mid-term safety of the Cryo-RDN was demonstrated.
Florian Krackhardt, MD, Konstantinos Tsioufis, MD, Lucas Lauder, MD, Natascha Drude, PhD, Jo Adaway, PhD, Brian Keevil, PhD, Holger Klemm, MSc, Wolfram Haider, DVM, Alicia Beele, MSc, Léa Wild, Med Vet, Michael Joner, MD, Felix Mahfoud, MD   +11 more
doaj   +1 more source

Cardiovascular and renal responses produced by central orphanin FQ/nociceptin occur independent of renal nerves

, 1999
The present study investigated the role of the renal nerves in mediating the cardiovascular and renal responses produced by the central administration of the opioid-like peptide orphanin FQ/nociceptin (OFQ/N) in conscious Sprague-Dawley rats.
Velga A. Kenigs, Daniel R. Kapusta
core   +1 more source