Results 51 to 60 of about 885,585 (253)

The Impact of Tenapanor on Body Composition and Blood Pressure in Peritoneal Dialysis Patients: A Pilot Study

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Instruction Tenapanor potentially affects fluid volume and blood pressure. This study explored its effects on these parameters in patients undergoing peritoneal dialysis (PD). Methods We conducted a single‐arm, prospective observational study that enrolled 10 patients on PD with hyperphosphatemia who were newly initiated on tenapanor.
Shun Yoshida, Kengo Asahina, Keiichi Osano, Natsumi Saegusa, Kohei Yamamura, Kie Ohkoshi, Miho Shikata, Toshihisa Ishii, Makiko Konishi, Kazuya Takahashi, Kohei Uchimura, Ayumu Nakashima   +11 more
wiley   +1 more source

Effects of Renal Denervation on Sympathetic Activation, Blood Pressure and Glucose Metabolism in Patients with Resistant Hypertension

Frontiers in Physiology, 2012
Increased central sympathetic drive is a hallmark of a number of important and common clinical conditions including essential hypertension, insulin resistance, heart failure, and chronic kidney disease.
Markus Peter Schlaich, Dagmara eHering, Paul A Sobotka, Henry eKrum, Gavin W Lambert, Elisabeth A Lambert, Murray D Esler   +6 more
doaj   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Excitation of cardiac sympathetic afferent nerves: effects on renal function

, 1981
Cardiac sympathetic afferent nerves can reflexly alter renal efferent nerve activity during myocardial ischemia and in response to mechanical or chemical stimulation of cardiac receptors. They also may influence renal excretion of water and electrolytes;
L. J. Macklem, R. L. Meckler, L. C. Weaver   +2 more
core   +1 more source

The heterodimeric amino acid transporters (HAT) of the SLC7/SLC3 family: A structure−function relationships and relevance to human pathology

FEBS Letters, EarlyView.
Heterodimeric amino acid transporters consist of SLC7 and SLC3 family proteins arranged in a conserved structural organization. They regulate nutrient transport across cell membranes, supporting essential cellular functions. These transporters also contribute to xenobiotic/drug uptake and distribution.
Mariafrancesca Scalise, Tiziano Mazza, Raffaella Scanga, Lara Console, Michele Galluccio, Cesare Indiveri   +5 more
wiley   +1 more source

Research progress and future directions of mesh basket-like six-electrode renal denervation system autonomic nerves modulation

Zhongguo Linchuang Yixue
The aim of this paper is to present the basic principles of the mesh basket-like six-electrode renal denervation (RDN) system, research progress in anti-hypertensive therapy and modulation of autonomic nerves for the treatment of diseases.
Yueping LI, Yujie ZHOU
doaj   +1 more source

Short-term Safety and Efficiency of Cryoablation for Renal Sympathetic Denervation in a Swine Model

Chinese Medical Journal, 2015
Background: Renal sympathetic nerves are involved in the reflective activation of the sympathetic nervous system in circulatory control. Catheter-based renal denervation (RDN) ameliorated treatment-resistant hypertension safely, but 10%-20% of treated ...
Meng Ji, Li Shen, Yi-Zhe Wu, Zhi-Feng Yao, Jia-Sheng Yin, Jia-Hui Chen, Jian-Guo Jia, Ling-Juan Qiao, Peng Liu, Jun-Bo Ge   +9 more
doaj   +1 more source

Neutralization of the PTX3/CD44 axis suppresses TGF‐β1 signaling in kidney fibrosis

FEBS Letters, EarlyView.
This study investigates how the PTX3/CD44 axis promotes kidney fibrosis by activating TGF‐β1 signaling. We demonstrate that the neutralizing antibody WHC‐001 effectively inhibits this pathway, suppressing myofibroblast activation and partial epithelial–mesenchymal transition (EMT).
Chao‐Chun Cheng, Shen‐Shin Chang, Feng‐Wei Chen, Ying‐Chieh Su, Thanh Phuong Nguyen, Yu‐Wei Hsiao, Jhih‐Ying Chi, Hsin‐Yin Liang, Ju‐Ming Wang   +8 more
wiley   +1 more source

H2O2 generated by NADPH oxidase 4 contributes to transient receptor potential vanilloid 1 channel-mediated mechanosensation in the rat kidney

, 2017
The presence of NADPH oxidase (Nox) in the kidney, especially Nox4, results in H2O2 production, which regulates Na+ excretion and urine formation.
Lin, Chian-Shiung;Lee, Shang-Hsing;Huang, Ho-Shiang;Chen, Yih-Sharng;Ma, Ming-Chieh, 陳益祥   +1 more
core   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source