Results 191 to 200 of about 1,855,085 (255)

Icariside II in Neurological Disorders: Mechanistic Insights Into Alzheimer's Disease, Cerebral Ischemia and Parkinson's Disease

open access: yesJournal of Biochemical and Molecular Toxicology, Volume 40, Issue 9, September 2026.
The graphical abstract represents the underlying neuroprotective potential of ICS II against Alzheimer's disease, Cerebral ischemia and Parkinson disease. ICS II downregulates ROS production, inflammation, mitochondrial dysfunction and apoptosis along with regulating their key signalling pathways.
Ashutosh Solanki   +4 more
wiley   +1 more source

Application of Serum CA125, HE4, ROMA, and CPH‐I in the Preoperative Differentiation of Ovarian Tumors: A Diagnostic Accuracy Study

open access: yesJournal of Clinical Laboratory Analysis, Volume 40, Issue 17, September 2026.
This study evaluated the diagnostic performance of CA125, HE4, ROMA, and CPH‐I in 345 patients with histologically confirmed ovarian tumors. CPH‐I showed favorable diagnostic performance overall and was particularly valuable in premenopausal women, whereas ROMA‐based strategies demonstrated optimal performance in postmenopausal women.
Weiming Feng   +6 more
wiley   +1 more source

Tissue‐Resident Macrophage in Inflammation and Cancer

open access: yesMedComm, Volume 7, Issue 9, September 2026.
Opposing macrophage functions in inflammation and cancer converge on shared mechanistic nodes, informing cross‐disease therapeutic strategies. ABSTRACT Tissue‐resident macrophages (TRMs) are long‐lived immune cells strategically distributed across organs, where their functional plasticity enables both homeostatic maintenance and pathological ...
Siyuan Huang   +13 more
wiley   +1 more source

Efficacy and Safety of Intraventricular Thiotepa in Combination With Methotrexate for Leptomeningeal Metastasis From Breast Cancer (NJMU‐BC04): A Single‐Arm Phase II Study

open access: yesMedComm, Volume 7, Issue 9, September 2026.
Leptomeningeal metastasis (LM), an uncommon yet highly fatal condition, involves malignant tumor infiltration of the meninges resulting in progressive neurological deterioration and severe quality‐of‐life impairment. LM remains largely refractory to treatment and lacks standardized treatment consensus, with a low intracranial objective response rate ...
Wenbin Zhou   +10 more
wiley   +1 more source

Costello Syndrome Associated With Somatic Mosaicism of Rare p.Gly13Asp HRAS Variant: Expanding the Phenotypic Spectrum

open access: yesMolecular Genetics &Genomic Medicine, Volume 14, Issue 9, September 2026.
We report a case of a 22‐year‐old woman with predominantly cutaneous involvement in whom whole‐exome sequencing from both blood‐ and hair‐derived DNA samples identified somatic mosaicism for the rare HRAS p.Gly13Asp variant. This case expands the phenotypic spectrum of Costello syndrome and underscores the importance of multitissue genomic analysis ...
Jovan Lalosevic   +6 more
wiley   +1 more source

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