Results 131 to 140 of about 299,677 (299)

Phase Separation of NFIB Suppresses SLC3A2‐Mediated Ferroptosis in Castration‐Resistant Prostate Cancer

Advanced Science, EarlyView.
Castration‐resistant prostate cancer (CRPC) remains sensitive to ferroptosis, but its intrinsic resistance is poorly understood. Here, we identify NFIB as a master suppressor. SIRT7‐mediated NFIB acetylation drives its liquid–liquid phase separation, which promotes SLC3A2 transcription to inhibit ferroptosis.
Qiunuo Li, Danyang Chen, Yongzhen Xia, Yili Long, Nan Huang, Rongna Li, Mengting Shi, Mairehaba Kadier, Huafeng Luo, Xiaohui Chen, Hao Liu, Guanmin Jiang   +11 more
wiley   +1 more source

The Use of Continuous Peritoneal Dialysis in Europe for the Treatment of Children with End-Stage Renal Failure: Data from the EDTA Registry [PDF]

, 2017
The demographic data on the use of continuous peritoneal dialysis in Europe for children starting renal replacement therapy under the age of 15 years was obtained from data collected by the Registry of the European Dialysis and Transplant Association ...
Broyer, M., Brunner, F. P., Brynger, H., Dykes, S. R., Enrich, J. H. H., Fassbinder, W., Geerlings, W., Rizzoni, G., Selwood, N. H., Tufveson, G., Wing, A. J.   +10 more
core  

Inhibition of repaglinide metabolism by letermovir prolonged severe hypoglycemia in a kidney transplant recipient: A case report and literature review

Renal Replacement Therapy
Background The prevention of cytomegalovirus (CMV) infection after kidney transplantation (KTx) is important. Letermovir (LTV), a drug used for CMV prophylaxis, has various drug–drug interactions.
Takashi Tsujimoto, Hiroki Kanou, Asuka Yamamoto, Hajime Sasaki, Tatsu Tanabe   +4 more
doaj   +1 more source

Rapid Remodeling of the Human Gut Microbiome in Response to Short‐Term Animal Product Restriction and Associations with Host Molecular Phenotypes

Advanced Science, EarlyView.
A real‐world model of structured animal product restriction practiced for religious reasons reveals the dynamic adaptability of the human gut microbiome to dietary change and uncovers reductions in diversity and rare taxa loss. Integrated microbiome, metabolomic, and proteomic analyses uncover coordinated taxonomic and molecular shifts and identify ...
Christina Emmanouil, Maria Anezaki, Alexandros Simistiras, Stavros Glentis, Nikolaos Scarmeas, Pantelis Hatzis, Konstantinos Rouskas, Antigone S. Dimas   +7 more
wiley   +1 more source

Ectopic parathyroid hormone-producing cervical cancer requiring hemodialysis owing to acute hypercalcemia: a case report

Renal Replacement Therapy
Background Parathyroid hormone-related protein (PTHrP) is often the underlying cause of malignancies complicated by hypercalcemia. However, in rare instances, ectopic production of parathyroid hormone (PTH) by tumors can be responsible, with ...
Yusuke Ushio, Yosuke Iwatani, Mayuko Suyama, Ayano Tanaka, Mihoko Mizutani, Momoko Seki, Yuka Shimizu, Koichiro Shiogai, Nagisa Ando, Nozomi Sato, Kouta Higashi, Masahide Tazawa, Kana Nomura, Haruka Kato, Anna Nakai, Hitoko Sumori, Shiho Makabe, Shizuka Kobayashi, Yuki Kawaguchi, Shun Manabe, Hiroshi Kataoka, Naoko Ito, Sekiko Taneda, Tomoko Yamamoto, Kosaku Nitta, Junichi Hoshino   +25 more
doaj   +1 more source

DOT1L Drives Endothelial‐to‐Mesenchymal Transition and Fibrotic Vascular Remodeling via H3K79 Methylation

Advanced Science, EarlyView.
DOT1L as a central epigenetic regulator of EndoMT and pulmonary fibrosis. Acting as an early epigenetic switch, it translates TGFβ–SMAD signaling into H3K79me2‐mediated chromatin remodeling, selectively activates fibrosis‐related genes, and primes ECs for rapid mesenchymal transition.
Yaofeng Wang, Xing Peng, Jingjing Chen, Yun Zhang, Tinghong Zhang, Jingyuan Zhang, Jiaying Fan, Hui Zheng, Qiaoyuan Liu, Zhimin Song, Zhan‐Peng Huang, Shu Meng   +11 more
wiley   +1 more source

β‐Adrenergic Signaling Promotes Anti‐Tumor Immunity in TP53‐mutant Oral Squamous Cell Carcinoma

Advanced Science, EarlyView.
β‐adrenergic stimulation enhances anti‐tumor immunity in TP53‐deficient oral squamous cell carcinoma by inducing tumor‐derived secretion of CXCL10, which attracts and activates cytotoxic CD8+ T cells. The findings demonstrate that β‐adrenergic signaling alters tumor–immune interactions via CXCL10‐mediated paracrine activation, revealing a neuro‐immune ...
Frederico O. Gleber‐Netto, Deborah Silverman, Tongxin Xie, Shamima Akhter, Nicole R. Vaughn, Adewale Adebayo, Kala Chand Debnath, Shorook Naara, Shajedul Islam, Erik Knutsen, Emily Lorin Ashkin, Simone Anfossi, Sara Leahey, Patrick Hwu, Sebastien Talbot, Erica K Sloan, Robert Saddawi‐Konefka, Roberto Rangel, Jeffrey N. Myers, George A. Calin, Moran Amit   +20 more
wiley   +1 more source

UK Scleroderma Study Group (UKSSG) guidelines on the diagnosis and management of scleroderma renal crisis [PDF]

, 2016
The UK Scleroderma Study Group developed guidelines on the diagnosis and management of scleroderma renal crisis (SRC) based on best available evidence and clinical experience.
Burns, A, Denton, CP, Harber, M, Lynch, BM, Ong, V, Stern, EP   +5 more
core  

PET Imaging of Cardiac Inflammation in Viral Myocarditis Using a DPP4‐Targeted Probe

Advanced Science, EarlyView.
This study describes a DPP4‐targeted PET probe for imaging myocardial inflammation by selectively targeting activated immune cells. Derived from the clinically approved small‐molecule inhibitor linagliptin, the probe demonstrates favorable biodistribution with specific cardiac uptake in myocarditis.
Wanhao Gao, Wenzhu Hu, Du Tang, Xinxin Liu, Kun Yu, Lixia Feng, Minyu Liao, Wang Lin, Wenqiang Zhu, Sanjay Rajagopalan, Xiaoli Lan, Jixin Zhong, Dao Wen Wang, Dawei Jiang, Xiaoquan Rao   +14 more
wiley   +1 more source

The first case of peritoneal dialysis-associated peritonitis caused by Gordonia otitidis

Renal Replacement Therapy
Background Gordonia spp. is a rare infectious disease that has been reported in only 18 cases to date as a cause of peritoneal dialysis-related peritonitis.
Tomoaki Miyazaki, Kei Matsumoto, Shugo Aoki, Akiko Takeshima   +3 more
doaj   +1 more source