Results 201 to 210 of about 538,702 (314)

Beyond Net Ultrafiltration Rate: A Precision Fluid Management Paradigm Integrating Three Key Parameters for Pediatric Continuous Renal Replacement Therapy. [PDF]

Crit Care Explor
Liu W, Wang C, Ye C, Xiong X, Li D, Bai K, Liu C.   +6 more
europepmc   +1 more source

A Novel IDO1/NE Dual Inhibitor, IMM‐H018 Prevents the Primary and Secondary Sepsis and Ameliorates the Kidney Injury Through Inhibiting the Cytokine Storm and Microthrombosis, and Reversing Immunosuppression

Advanced Science, EarlyView.
IMM‐H018, a dual IDO1/NE inhibitor, demonstrates potent therapeutic efficacy in sepsis by simultaneously targeting excessive inflammation and immune dysfunction. It prevents both primary and secondary sepsis through anti‐inflammatory, immune‐restoring, and renoprotective mechanisms, reducing organ damage, improving immune homeostasis, preserving kidney
Yi Zhou, Xiaodi Zhao, Xiaochen Pan, Zhiling Ma, Huaqing Cui, Hui Wen, Peng Wang, Xiufeng Liao, Kejie Qin, Yuchen Wang, Li Sheng, Sen Zhang   +11 more
wiley   +1 more source

Risk prediction of continuous renal replacement therapy in patients with acute kidney injury after lung transplantation. [PDF]

J Intensive Med
Ding S, Lin H, Chen J, Mai S, Zhu G, Teng G, Chen J, Huang M.   +7 more
europepmc   +1 more source

Targeted β‐Glucan‐Veiled Oral Apremilast Nanotherapy Modulates Key Dysbiosis‐Associated Gut Microbiota and Alleviates Ulcerative Colitis‐Associated Anxiety, Depression, and Neuropsychiatric Behaviors

Advanced Science, EarlyView.
This study introduces β‐glucan‐shielded apremilast laden nanomicelles that withstand gastrointestinal degradation, selectively accumulate in inflamed colon tissue, and modulate the microbiota–gut–brain axis. The formulation restores barrier integrity, reduces systemic and neuroinflammation, and improves anxiety‐ and depression‐like behaviors in colitis
Chandrashekhar Jori, Ahmed Shaney Rehman, Taruna Lamba, Anas Ahmad, Jattin Kumar, Aneesh Ali, Ajesh Joshi, Ashraf Ali, Suhel Parvez, Javed N. Agrewala, Rehan Khan   +10 more
wiley   +1 more source

Postangiography Prediction of Renal Replacement Therapy in Acute Myocardial Infarction-Related Cardiogenic Shock: Least Absolute Shrinkage and Selection Operator Nomogram Development and Validation. [PDF]

JMIR Cardio
Daoulah A, M Ladna J, Arabi A, Elmahrouk A, Seraj S, M Aloui H, Alshehri M, Almahmeed W, Panduranga P, Yousif N, Lotfi A, Qutub M, Alharbi W, Rajan R, Abdirahman Kahin M, Alenezi A, Al Maashani S, Hassan T, Alswuaidi J, Eltaieb F, Abdulhadi Aldossari M, Al Jarallah M, Elganady A, Alzahrani B, Alqahtani A, Omar M Al Nasser F, A Noor H, Alama MN, Aldossari A, Al Obaikan S, Ali Almarghany A, Kanbr O, Elmahrouk Y, A M Abdulhabeeb I, Balghith M, S Hersi A, Antony H, Fathey Hussien A, Almoghairi A, Alama MMA, Ajaz Ghani M, Rahbi H, Basardah A, Alshehri B, Alama A, AlObaid L, Abualnaja S, Shahzad Chachar T, Khan H, Hashmani S, A Ghonim A, Almerri K, Alsofayan R, M Tawengi A, M Shawky A, Alshehri A, Arafat A, Jamjoom A.   +57 more
europepmc   +1 more source

Histone H3K18 Lactylation Promotes the Malignant Progression of Wilms Tumor via a PSRC1/AKT/HIF‐1α Positive Feedback Loop

Advanced Science, EarlyView.
In nephroblastoma, aberrant glycolysis drives lactate accumulation, which elevates histone H3K18 lactylation via p300. Lactylation of the PSRC1 promoter activates its transcription. PSRC1 competitively binds AKT, relieving PTEN‐mediated inhibition and triggering AKT/mTOR/HIF‐1α signaling.
Yanping Wang, Hongjie Gao, Bifei Zhang, Xuetian Li, Ding Li, Aihua Cao, Fengyin Sun   +6 more
wiley   +1 more source

A Single-Center Review of Renal Replacement Therapy in Patients With Acute Traumatic Brain Injury. [PDF]

Cureus
Topper G, Bamimore M, Hess T, Metheny J, Morris P, Plumb J, Valeri A, Hunter K, Mossop C, Egodage T.   +9 more
europepmc   +1 more source

Probiotic‐Derived Vesicles Rectally Delivered via Thermo‐Gelling Copolymer Promote Mucosal Healing and Reduce Inflammation in Ulcerative Colitis

Advanced Science, EarlyView.
A thermo‐responsive rectal delivery platform integrating probiotic‐derived extracellular vesicles within a hyaluronic acid‐based copolymer enables localized and sustained therapy for ulcerative colitis. The formulation effectively suppresses inflammation, promotes macrophage polarization toward a regenerative phenotype, restores epithelial barrier ...
Ayushi Mairal, Ubaid Tariq, Shreya Mehrotra, Saravanan Matheshwaran, Jan Marsal, Ashok Kumar   +5 more
wiley   +1 more source