Results 81 to 90 of about 166,272 (252)

Ultrasound‐Responsive Dual‐Prodrug Nanoassembly for “Fenestrae‐Restoration Strategy” in Liver Fibrosis Therapy

Advanced Materials, EarlyView.
ABSTRACT Liver fibrosis is a serious yet reversible intermediate stage in the progression of liver disease, which can ultimately advance to cirrhosis and hepatocellular carcinoma. Targeted and selective inhibition of activated hepatic stellate cells (aHSCs) has emerged as a promising therapeutic strategy for the treatment of liver fibrosis.
Shutong Liu, Mengyao Zhang, Zitong Qiu, Xinyi Liu, Yunsheng Dou, Sona Krizkova, Zheyi Li, Zbynek Heger, Nan Li   +8 more
wiley   +1 more source

Effective diagnosis and localization of pleuroperitoneal communication in a patient on peritoneal dialysis using contrast-enhanced ultrasonography and pneumoperitoneum: a case report and literature review

Renal Replacement Therapy
Background Pleuroperitoneal communication (PPC) is a serious complication that may necessitate the discontinuation of peritoneal dialysis. Accurate identification of the communication site is essential for successful thoracoscopic surgery. In this report,
Satoko Yamamoto, Ghahei Lee, Hirofumi Taniguchi, Tomoka Imanaka, Seiichi Yasuda, Kenji Nishimura, Yasushi Seki, Sachiyo Kogita, Yoshiyuki Susaki, Hirofumi Ota, Nobuyuki Kajiwara   +10 more
doaj   +1 more source

Efficacy and Safety Assessment of 5‐Fluorouracil, Irinotecan and Oxaliplatin‐Loaded Implants in Mouse and Pig Models for Pancreatic Cancer Therapy

Advanced Materials, EarlyView.
A novel FIRINOX‐loaded implant demonstrates controlled drug release, and potent therapeutic efficacy in pancreatic ductal adenocarcinoma mouse models with safety confirmed in a large‐animal pre‐clinical model. This innovative drug delivery platform offers a promising new treatment approach for non‐resectable, treatment‐resistant pancreatic cancer ...
Samantha J. Wade, Ashna A. Kumar, Samuel O. Nitschke, Paul Joyce, Elahe Minaei, Stephanie E. Reuter Lange, Chelsea Penney, Holly Warren, Ruby Shepherd, Jeremy N. Dinoro, Gordon G. Wallace, Anthony Dosseto, Sameera Ansar, Naila Islam, Alistair Lochhead, George Sharbeen, Phoebe A. Phillips, Morteza Aghmesheh, Wayne J. Hawthorne, Kara L. Vine‐Perrow   +19 more
wiley   +1 more source

Effect of right ventricular dysfunction on mortality in patients undergoing maintenance hemodialysis: a retrospective cohort study

Renal Replacement Therapy
Background Cardiovascular disease (CVD) is a major complication in patients on maintenance hemodialysis (MHD). While the effect of left ventricular dysfunction on patients on MHD is well known, the association between right ventricular (RV) dysfunction ...
Hiroki Nobayashi, Harui Bamba, Tomomichi Iida, Ryuji Aoyagi, Yukio Maruyama, Takashi Yokoo   +5 more
doaj   +1 more source

Engineered Microfluidic Organoid Systems: New Paradigms for Menopause Mechanism Research and Personalized Medicine

Advanced Materials Technologies, EarlyView.
This review explores the integration of microfluidic technology with organoid systems as an innovative platform for studying menopausea complex multi‐organ condition. By enabling precise simulation of inter‐organ communication and hormone responses, microfluidic organoids offer a physiologically relevant model for investigating menopausal syndrome and ...
Qianyi Zhang, He Huang, Hongliang Dong, Qiang Ma, Hongyan Jin   +4 more
wiley   +1 more source

Retroperitoneal leakage causing ultrafiltration failure during continuous ambulatory peritoneal dialysis: a case report and literature review

Renal Replacement Therapy
Background Peritoneal dialysis (PD) is associated with various complications, and the leakage of dialysate can lead to the discontinuation of PD. Retroperitoneal leakage (RPL) can be diagnosed on the basis of dialysate leakage, and, because there are few
Rina Tamai, Makoto Ochi, Yoshino Hiraaki, Yukinori Toyoshima, Daisuke Sumitani, Masayuki Shishida, Masatsugu Yano, Hiroaki Oda, Hideki Ohdan   +8 more
doaj   +1 more source

Cross‐Scale Hierarchical Targeted Delivery System Based on Small‐Scale Magnetic Robots

Advanced Robotics Research, EarlyView.
This article reviews a cross‐scale hierarchical targeted delivery system that integrates magnetic continuum robots and magnetic microrobots. By combining rapid long‐range navigation with precise microscale targeting, the system overcomes key limitations of single‐scale approaches.
Junjian Zhou, Zhiqiang Chen, Yuanbiao Ma, Zhiqiang Tang, Qianqian Wang   +4 more
wiley   +1 more source

Successful autologous blood pleurodesis in two maintenance hemodialysis patients with idiopathic refractory pleural effusion: case reports and literature review

Renal Replacement Therapy
Background Refractory pleural effusion occasionally occurs in patients undergoing maintenance hemodialysis and is associated with a poor prognosis. We recently encountered idiopathic refractory pleural effusion in two patients undergoing maintenance ...
Ryoichi Miyazaki, Kyoko Miyagi, Tatsuhito Miyanaga, Kazuhiko Igarashi, Mitsuo Awaji   +4 more
doaj   +1 more source

Magnetic Micro‐ and Nanorobots for Precision Thrombolysis: Design Strategies and Translational Challenges

Advanced Robotics Research, EarlyView.
Micro‐ and nanorobots for targeted thrombolysis. This perspective elaborates on the clinical indication of blood clot disorders and current limitations for treatment. As a novel, alternative solution, micro‐ and nanorobots can be used to treat and break down thrombi.
Joshua M. Mesfin, Yimo Yan, Nikola Cesarovic, Simone Schuerle   +3 more
wiley   +1 more source

Inhibition of repaglinide metabolism by letermovir prolonged severe hypoglycemia in a kidney transplant recipient: A case report and literature review

Renal Replacement Therapy
Background The prevention of cytomegalovirus (CMV) infection after kidney transplantation (KTx) is important. Letermovir (LTV), a drug used for CMV prophylaxis, has various drug–drug interactions.
Takashi Tsujimoto, Hiroki Kanou, Asuka Yamamoto, Hajime Sasaki, Tatsu Tanabe   +4 more
doaj   +1 more source