Results 171 to 180 of about 10,740 (300)

Leveraging Artificial Intelligence and Large Language Models for Cancer Immunotherapy

Advanced Science, EarlyView.
Cancer immunotherapy faces challenges in predicting treatment responses and understanding resistance mechanisms. Artificial intelligence (AI) and machine learning (ML) offer powerful solutions for cancer immunotherapy in patient stratification, biomarker discovery, treatment strategy optimization, and foundation model development.
Xinchao Wu, Mengtao Sun, Lusheng Li, Jieqiong Wang, Shibiao Wan   +4 more
wiley   +1 more source

Enhancing CAR‐T Cell Efficacy in Solid Tumors by Inhibiting CCL5/VEGF‐Mediated Angiogenesis

Advanced Science, EarlyView.
This study reveals that CAR‐T cells in solid tumors produce CCL5, which paradoxically induces VEGF and angiogenesis to promote tumor growth. Blocking CCL5/VEGF signaling—through gene knockout, or the CCR5 inhibitor maraviroc—significantly enhances the antitumor efficacy of CAR‑T therapy (the diagram was created in Biorender).
Shishuo Sun, Qihong Li, Bixi Wang, Gang Wang, Ying Xue, Yibing Liang, Chenhe Hu, Zhenyu Wang, Xiaoge Gao, Haiheng Xu, Jun Song, Hailong Li, Liantao Li, Xiaoxiao Liu, Patrick Ming‐Kuen Tang, Qing Zhang   +15 more
wiley   +1 more source

Assessment of renal resistive index measurement in children with immunoglobulin A vasculitis. [PDF]

Reumatologia
Ekinci RMK, Pekoz BC, Taner S.
europepmc   +1 more source

Prognostic Role of Measurement of Renal Resistive Index in Systemic Sclerosis. [PDF]

Mediterr J Rheumatol, 2021
Sharma SK, Chattopadhyay A, Jain S, Sharma CR, Mishra D, Rathi M, Prakash M, Jain S.   +7 more
europepmc   +1 more source

A Circuit of Mechanically Regulated Transcription Factors Balances Regenerative and Fibrotic Memory of Mesenchymal Stromal Cells

Advanced Science, EarlyView.
Producing MSCs on rigid culture substrates induces a scar‐making phenotype, jeapordizing therapeutic success. ‘Tissue‐soft’ surfaces prevent MSC fibrogenesis and preserve regenerative traits. An epigenetic network, driven by HOXA11 and SALL1, maintains ‘soft memory’ by keeping chromatin open in relaxed MSCs, promoting anti‐fibrotic programs.
Fereshteh Sadat Younesi, Andrew E. Miller, Li Diao, Xinying Guo, Natalie Andonian, Elham Karimizadeh, Thomas H. Barker, Boris Hinz   +7 more
wiley   +1 more source

Perioperative Changes in Renal Resistive Index as a Predictor of Acute Kidney Injury After Cardiac Surgery: A Prospective Cohort Study. [PDF]

J Clin Med
Sabia M, Isetta C, Banydeen R, Durand N, Mehdaoui H, Licker M.   +5 more
europepmc   +1 more source

Is the Renal Resistive Index a Marker for Revascularization in Atherosclerotic Renal Artery Stenosis? [PDF]

Cureus, 2021
Vemireddy LP, Ying GW, Aqeel A, Baig S, Buddharaju V.   +4 more
europepmc   +1 more source

Aerospace Medicine and Biology: A continuing bibliography, supplement 216 [PDF]

One hundred twenty reports, articles, and other documents introduced into the NASA scientific and technical information system in January 1981 are listed.

core   +1 more source

Fully Humanized Bispecific T Cell Engager Shows Potent Activity in Central Nervous System and Peripheral Tumors

Advanced Science, EarlyView.
This study reports the development of a fully humanized bispecific T cell engager targeting IL13RA2, a tumor‐associated antigen enriched in glioblastoma. This off‐the‐shelf immunotherapy drives potent, antigen‐dependent T cell activation and tumor killing, and prolongs survival in experimental GBM and other solid tumors models without detectable off ...
Joseph T. Duffy, Angela Martin‐Regalado, Benedikt E. Haupt, Jacob R. Pogue, Aditi Thakur, Manuel Fierro Cota, Markella Zannikou, Sol Misener, Vera P. Krymskaya, Kathleen McCortney, Jason Miska, Craig Horbinski, Dmitri Simberg, Maciej S. Lesniak, Charles D. James, Roger Stupp, Irina V. Balyasnikova   +16 more
wiley   +1 more source

Predictability performance of urinary C-C motif chemokine ligand 14 and renal resistive index for persistent sepsis-associated acute kidney injury in ICU patients. [PDF]

Int Urol Nephrol, 2023
Jiang W, Liao T, Yu J, Shao J, Zheng R.
europepmc   +1 more source