Results 141 to 150 of about 380,167 (333)

Metabolic Reprogramming of T Cells by Dual UCP2 and IL‐17 Blockade Enhances Immunity Against Pancreatic Cancer

Advanced Science, EarlyView.
This study demonstrates that dual UCP2/IL‐17 blockade reprograms T‐cell metabolism to overcome PDAC immunosuppression. Genipin‐mediated UCP2 inhibition enhances CD8⁺ T‐cell IFN‐γ via IL‐12R/STAT4/mTOR signaling and mitochondrial OXPHOS. Combined IL‐17 depletion amplifies Tc1/Th1 responses, reduces MDSCs, and prolongs survival in PDAC models ...
Chuan‐Teng Liu, Chun‐Chieh Yeh, Tsai‐Chen Wu, Chia‐Hsin Lin, Yi‐Ting Kuo, Yoichiro Iwakura, Yuan‐Ji Day, Charles Drake, Vedran Radojcic, Ying‐Chyi Song, Heng‐Hsiung Wu, Hung‐Rong Yen   +11 more
wiley   +1 more source

High prevalence of febrile urinary tract infections after paediatric renal transplantation [PDF]

, 2006
Ulrich John, Anne Schulze Everding, Eberhard Kuwertz-Bröking, M. Bulla, D. E. Müller‐Wiefel, Joachim Misselwitz, Markus J. Kemper   +6 more
openalex   +1 more source

HSP70 Interactome‐Mediated Proteolysis Targeting Chimera (HSP70‐PROTAC) for Ferroptosis‐Driven Cancer Treatment

Advanced Science, EarlyView.
This study reports a novel targeted protein degradation strategy termed “HSP70‐PROTAC” that recruits Hsc70 complex to a target protein for inducing degradation. Among them, GDAz‐3 exhibits effective GPX4 degradation activity via UPS/CMA processes, triggering ferroptosis‐driven anticancer activity in vitro and in vivo.
Jinyun Dong, Yulong Li, Hui Liang, Zumei Wu, Shiqun Wang, Yichao Wang, Jieyu Xu, Yanning Lan, Maohua Cai, Guangzhao Pan, Haiyan Yang, Kai Miao, Zhe‐Sheng Chen, Fangfang Tao, Xuelei Ma, Jiang‐Jiang Qin   +15 more
wiley   +1 more source

Renal transplantation in advanced cardiac failure patients

, 1997
Won Hyun Cho, H.T. Kim, C.H. Park, Suk J, S.B. Park, H.C. Kim   +5 more
openalex   +2 more sources

Combined Photothermal and mTOR‐Targeted Therapy Overcomes Immune Evasion and Enhances Checkpoint Blockade Efficacy in Metastatic Triple‐Negative Breast Cancer

Advanced Science, EarlyView.
This study reveals that photothermal therapy, while inducing immunogenic cell death in triple‐negative breast cancer, paradoxically activates the oncogenic mTOR pathway to drive immune evasion. To counter this, a smart nanocomposite is engineered to co‐deliver localized hyperthermia and mTOR inhibition.
Yujie Zhao, Jing Yu, Xin Wang, Xu Liu, Fengli Zuo, Tianyue Xu, Leyi Tang, Ling Xiong, Li Li, Huifang Li, Xiaoting Chen, Guang Yang, Jing Jing, Xiaowei Liu   +13 more
wiley   +1 more source

A Phase I Dose-Escalation Trial of High-Dose Melphalan with Palifermin for Cytoprotection Followed by Autologous Stem Cell Transplantation for Patients with Multiple Myeloma with Normal Renal Function [PDF]

, 2012
Muneer H. Abidi, Rishi Agarwal, Nishant Tageja, Lois Ayash, Abhinav Deol, Zaid Al‐Kadhimi, Judith Abrams, Simon Cronin, Marie Ventimiglia, Lawrence G. Lum, Voravit Ratanatharathorn, Jeffrey A. Zonder, Joseph P. Uberti   +12 more
openalex   +1 more source

Antiemesis Corticosteroids Potentiate Checkpoint Blockade Efficacy by Normalizing the Immune Microenvironment in Metastatic Murine Breast Cancer

Advanced Science, EarlyView.
Corticosteroids improve the efficacy of immune checkpoint blockade therapy in metastatic murine breast cancer. By normalizing the tumor immune microenvironment, corticosteroids reduce immunosuppressive signals, restore T‐cell function, and promote antitumor immune responses, resulting in enhanced tumor control.
John D. Martin, Koji Nagaoka, Myrofora Panagi, Akihiro Hosoi, Fotios Mpkeris, Pengwen Chen, Thahomina T. Khan, Margaret R. Martin, Changbo Sun, Chrysovalantis Voutouri, Maria Louca, Panagiotis Papageorgis, Akira Sumiyoshi, Nobuhiro Nitta, Kazuyoshi Takeda, Ichio Aoki, Kazunori Kataoka, Triantafyllos Stylianopoulos, Kazuhiro Kakimi, Horacio Cabral   +19 more
wiley   +1 more source

A CASE OF SUCCESSFUL RECOVERY OF RENAL ALLOGRAFT FUNCTION FOLLOWING A DIAGNOSIS OF THROMBOTIC MICROANGIOPATHY CLINICALLY MADE IN THE IMMEDIATE POST-TRANSPLANT PERIOD

, 2017
Yujiro Hayashi, Akira Nagahara, Atsunari Kawashima, Yoichi Kakuta, Takeshi Ujike, Toyofumi Abe, Shinichiro Fukuhara, Kazutoshi Fujita, Motohide Uemura, Hiroshi Kiuchi, Ryoichi Imamura, Yasushi Miyagawa, Naotsugu Ichimaru, Tetsuo Maeda, Norio Nonomura   +14 more
openalex   +2 more sources

Optimizing Intraoperative Blood Pressure to Improve Outcomes in Living Donor Renal Transplantation

, 2020
Kohei Kinoshita, Shigeyoshi Yamanaga, Akari Kaba, Kosuke Tanaka, Masatomo Ogata, Mika Fujii, Yuji Hidaka, Chiaki Kawabata, Mariko Toyoda, Soichi Uekihara, Masayuki Kashima, Akira Miyata, Akito Inadome, Takaaki Kobayashi, Hiroshi Yokomizo   +14 more
openalex   +1 more source

Entecavir treatment for chronic hepatitis B infection in end‐stage renal disease and kidney transplantation [PDF]

, 2010
Ezequiel Ridruejo, Raúl Adrover, Cristina Alonso, Oscar G. Mandό, Marcelo Silva   +4 more
openalex   +1 more source