Results 71 to 80 of about 39,368 (264)

Enhancing CAR‐T Cell Efficacy in Solid Tumors by Inhibiting CCL5/VEGF‐Mediated Angiogenesis

Advanced Science, EarlyView.
This study reveals that CAR‐T cells in solid tumors produce CCL5, which paradoxically induces VEGF and angiogenesis to promote tumor growth. Blocking CCL5/VEGF signaling—through gene knockout, or the CCR5 inhibitor maraviroc—significantly enhances the antitumor efficacy of CAR‑T therapy (the diagram was created in Biorender).
Shishuo Sun, Qihong Li, Bixi Wang, Gang Wang, Ying Xue, Yibing Liang, Chenhe Hu, Zhenyu Wang, Xiaoge Gao, Haiheng Xu, Jun Song, Hailong Li, Liantao Li, Xiaoxiao Liu, Patrick Ming‐Kuen Tang, Qing Zhang   +15 more
wiley   +1 more source

Case Report of a Transplant Renal Artery Stenosis: Delayed Diagnosis, Correct Treatment

Turkish Journal of Nephrology, 2019
Renal artery stenosis is observed in 1-23% of the transplanted kidneys. It may result in graft dysfunction and hypertension but anuria is rare in patients with graft renal artery stenosis.
Ayhan HASPULAT, İbrahim AKDAĞ, Hadim AKOĞLU, Güner KARAVELİ GÜRSOY, Özlem YAYAR, Zafer ERCAN, Özgür MERHAMETSİZ, Ebru GÖK OĞUZ, Tolga YILDIRIM, Deniz AYLI   +9 more
doaj  

A Circuit of Mechanically Regulated Transcription Factors Balances Regenerative and Fibrotic Memory of Mesenchymal Stromal Cells

Advanced Science, EarlyView.
Producing MSCs on rigid culture substrates induces a scar‐making phenotype, jeapordizing therapeutic success. ‘Tissue‐soft’ surfaces prevent MSC fibrogenesis and preserve regenerative traits. An epigenetic network, driven by HOXA11 and SALL1, maintains ‘soft memory’ by keeping chromatin open in relaxed MSCs, promoting anti‐fibrotic programs.
Fereshteh Sadat Younesi, Andrew E. Miller, Li Diao, Xinying Guo, Natalie Andonian, Elham Karimizadeh, Thomas H. Barker, Boris Hinz   +7 more
wiley   +1 more source

Engineering Approaches to Modify Immunomodulatory Functions of Mesenchymal Stromal Cells (MSCs): Tissue Regeneration and Clinical Application

Advanced Science, EarlyView.
Mesenchymal stromal cells (MSCs) show promise for treating immune‐related disorders through immunomodulation and tissue regeneration. This review gives a brief overview of current clinical approval of MSC therapies. It also discussed how bioengineering, including genetic modification, biomaterial delivery, extracellular vesicles, and iPSC‐derived MSCs,
Sichen Yang, Kejia Li, Ning Wang, Zhen Li, Zhiyong Zhang, Rocky S. Tuan, Yangzi Jiang   +6 more
wiley   +1 more source

A Case of Mucormycosis Postrenal Transplant Masquerading Renal Cortical Necrosis

Indian Journal of Transplantation
Mucormycosis is a virulent angioinvasive fungal infection that predominantly affects immunocompromised individuals, particularly solid organ transplant recipients.
Sunny Rajnikant Malde, Manish Balwani, Amit Pasari, Kapil Sejpal, Twinkle Vishwajit Pawar, Pranjal Kashiv, Shubham Dubey, Sushrut Gupta, Vijay Jeya Chandran, Mohit Kurundwadkar   +9 more
doaj   +1 more source

Very-late-onset cytomegalovirus disease: a case-report and review of the literature

BMC Research Notes, 2017
Background Cytomegalovirus (CMV) infection remains one of the most common and feared complications of transplantation, justifying prophylaxis or preemptive strategies guided by donor and recipient CMV serostatus.
Hania Burgan, Gael Gosteli, Marc Giovannini, Reto Lienhard, Olivier Clerc   +4 more
doaj   +1 more source

Hypertension in renal transplant recipients

Kidney International, 1987
A 29-year-old black woman was evaluated at another hospital because of epistaxis and a blood pressure of 300/150mm Hg. At age 18 she was refused entrance to the military because of hypertension. Between the ages of 20 and 24 years, she had 3 pregnancies, each complicated by toxemia. Although hypertension was noted on occasion over the subsequent years,
openaire   +2 more sources

Bioorthogonal Fluorogenic Reporters for Noninvasive Imaging and Urinalysis of Immunotherapeutic Response in Renal Cell Carcinoma

Advanced Science, EarlyView.
This study reported renal‐clearable bio‐orthogonal near‐infrared fluorogenic probes (BGRs) that specifically imaging and urinalysis of granzyme B for dynamic evaluation of RCC immunotherapy. BGRs not only differentiate immunotherapeutic responses in orthotopic RCC mice, but also enable sensitive optical urinalysis of granzyme B in clinical specimens ...
Xingyue Yang, Baoshuai Liang, Liangmin Fu, Weiliang Deng, Yuyan Jiang, Weiping Xu, Jinwei Chen, Ya Zhou, Ke Wu, Jiaguo Huang   +9 more
wiley   +1 more source

Recurrent septicemia in a renal transplant recipient

Saudi Journal of Kidney Diseases and Transplantation, 2009
The incidence of infection is significantly elevated in renal transplant recipients,but native kidney infection is an uncommon event in these patients.
Nejad-Gashti Hossein, Sanavi Suzan, Afshar Reza   +2 more
doaj  

A Biomimetic Lubricant Captures Hyaluronic Acid In Situ to Regenerate Cartilage: From Bench to Bedside

Advanced Science, EarlyView.
(a) The outstanding lubricative properties of natural articular cartilage arise from a composite coating composed of HA, lubricin, and phospholipids at its surface. Notably, lubricin facilitates the enrichment of synovial HA onto cartilage surfaces, and HA complexes with phospholipids, a key component to maintain extremely low friction under high ...
Yongan Lin, Zijian Yan, Jiayi Chen, Xiaochao Wang, Ruibin Lin, Yunqi Fu, Zhaoying Lv, Bohui Wu, Xuewei Cao, Renjian Xie, Ming Dong, Chenxiao Zheng, Li Ren   +12 more
wiley   +1 more source