Results 51 to 60 of about 2,503,709 (341)

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

Hematopoietic (stem) cells—The elixir of life?

FEBS Letters, EarlyView.
The aging of HSCs (hematopoietic stem cells) and the blood system leads to the decline of other organs. Rejuvenating aged HSCs improves the function of the blood system, slowing the aging of the heart, kidney, brain, and liver, and the occurrence of age‐related diseases.
Emilie L. Cerezo, Jonah Anderson, Emilie Dinh Vedrenne, Noël Yeh Martín, Jette Lengefeld   +4 more
wiley   +1 more source

Gut microbiota diversity is prognostic in metastatic hormone receptor‐positive breast cancer patients receiving chemotherapy and immunotherapy

Molecular Oncology, EarlyView.
In this exploratory study, we investigated the relationship between the gut microbiota and outcome in patients with metastatic hormone receptor‐positive breast cancer, treated in a randomized clinical trial with chemotherapy alone or chemotherapy in combination with immune checkpoint blockade.
Andreas Ullern, Kristian Holm, Nikolai Kragøe Andresen, Andreas Hagen Røssevold, Corinna Bang, Bjørn Naume, Johannes R. Hov, Jon Amund Kyte   +7 more
wiley   +1 more source

Liquid biopsy epigenetics: establishing a molecular profile based on cell‐free DNA

Molecular Oncology, EarlyView.
Cell‐free DNA (cfDNA) fragments in plasma from cancer patients carry epigenetic signatures reflecting their cells of origin. These epigenetic features include DNA methylation, nucleosome modifications, and variations in fragmentation. This review describes the biological properties of each feature and explores optimal strategies for harnessing cfDNA ...
Christoffer Trier Maansson, Anders Lade Nielsen, Boe Sandahl Sorensen   +2 more
wiley   +1 more source

The Banff 97 working classification of renal allograft pathology.

Kidney International, 1999
BACKGROUND Standardization of renal allograft biopsy interpretation is necessary to guide therapy and to establish an objective end point for clinical trials.
L. Racusen, K. Solez, R. Colvin, S. Bonsib, M. C. Castro, T. Cavallo, B. Croker, A. Demetris, C. Drachenberg, A. Fogo, P. Furness, L. Gaber, I. Gibson, Dennis Glotz, J. Goldberg, Joseph Grande, P. Halloran, H. E. Hansen, B. Hartley, P. Hayry, C. Hill, E. Hoffman, L. Hunsicker, A. Lindblad, N. Marcussen, M. Mihatsch, T. Nadasdy, P. Nickerson, T. Olsen, J. Papadimitriou, P. Randhawa, D. Rayner, I. Roberts, S. Rose, D. Rush, L. Salinas‐Madrigal, D. Salomon, S. Sund, E. Taskinen, K. Trpkov, Y. Yamaguchi   +40 more
semanticscholar   +1 more source

Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer

Molecular Oncology, EarlyView.
PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta, Yang Song, Madeleine Ndahayo, Anirudh Saxena, Theresa Guo, Dylan Z. Kelley, Jessica Gore, Andrew Hennigan, Alexa Anderson, John C. Papadimitriou, Daria A. Gaykalova   +10 more
wiley   +1 more source

Protocol Biopsies Reveal Progressive Arteriolar Thickening as a Predictor of Mortality in Kidney Transplant Recipients

Life
Kidney transplant recipients remain at high risk of cardiovascular events and premature death. Whether chronic histological changes in protocol allograft biopsies provide prognostic information for patient outcomes beyond graft survival remains uncertain.
Diana Rodríguez-Espinosa, Evelyn Hermida, Agustín Leal-Cúpich, Adriana García, Ana Belén Larque, Elena Cuadrado-Payán, Elena Guillén-Olmos, Marina Moncada, Pedro Ventura-Aguiar, David Cucchiari, Nuria Esforzado, Ignacio Revuelta, Fritz Diekmann, José Vicente Torregrosa, José Jesús Broseta   +14 more
doaj   +1 more source

Stepwise differentiation of follicular helper T cells reveals distinct developmental and functional states

Nature Communications, 2023
Follicular helper T (Tfh) cells are essential for the formation of high affinity antibodies after vaccination or infection. Although the signals responsible for initiating Tfh differentiation from naïve T cells have been studied, the signals controlling ...
Manuel A. Podestà, Cecilia B. Cavazzoni, Benjamin L. Hanson, Elsa D. Bechu, Garyfallia Ralli, Rachel L. Clement, Hengcheng Zhang, Pragya Chandrakar, Jeong-Mi Lee, Tamara Reyes-Robles, Reza Abdi, Alos Diallo, Debattama R. Sen, Peter T. Sage   +13 more
doaj   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Initial Experience of Contact Laser Vaporization of the Prostate (CVP) for Benign Prostate Hyperplasia Patients With Hemorrhagic Risk

Advances in Urology
Conclusion: CVP treatment appears to be acceptable for BPH patients with hemorrhagic risk. In this study, late-onset hemorrhage occurred approximately 1 month postoperatively. Close postoperative follow-up is required.
Yushi Araki, Takashi Kawahara, Teppei Takeshima, Kazuhide Makiyama, Hiroji Uemura   +4 more
doaj   +1 more source