Results 61 to 70 of about 33,929 (298)
How do we get there? Dynamics of strategic renewal: a multiple case study of Polish SMEs [PDF]
Central European Management JournalPurposeThe purpose of this study is to explore the dynamics of strategic renewal over time concerning its underlying and interrelated constituents.Design/methodology/approachThis study employs multiple case study of three Polish-owned SMEs ...
Piotr Wójcik +3 more
doaj +1 more source
Hydrostatic pressure activates HIF‐1α via β‐catenin to promote stemness in breast cancer cells
FEBS Open Bio, EarlyView.To mimic the elevated intestinal fluid pressure in breast cancers, we loaded human breast cancer cells (MCF‐7, MDA‐MB‐453, and BT‐474) to 50 mmHg hydrostatic pressure. Hydrostatic pressure exposure upregulated HIF‐1α and induced stemness in MCF‐7 and BT‐474 cells.
Da Zhai +8 more
wiley +1 more source
FEBS Open Bio, EarlyView.The cytoskeleton‐mediated transport of mitochondria via tunnelling nanotubes restores respiration, increases ATP production, rescues cells from apoptosis, activates the AKT/mTOR signalling pathway, promotes cell migration and invasiveness, contributes to cancer progression and treatment resistance.
Stanislava Martínková, Jan Trnka
wiley +1 more source
Mutant NPM1 in Acute Myeloid Leukemia Initiation and Maintenance
Aging and Cancer, EarlyView.NPM1 mutations drive acute myeloid leukemia by acting as neomorphic transcriptional regulators that cooperate with Menin–MLL and XPO1 to sustain HOX/MEIS1 expression and block differentiation. Targeting these mutant‐specific transcriptional dependencies provides a rational therapeutic strategy for NPM1‐mutated AML.
Yanan Jiang +3 more
wiley +1 more source
New Directions for Adult and Continuing Education, EarlyView.ABSTRACT Mental well‐being is central to adult learner success, yet many adult education institutions lack capacity to provide timely and accessible support. This article examines how artificial intelligence (AI) can strengthen mental health–adjacent supports in adult and continuing higher education, with attention to professional practice and ...
Adam L. McClain, Thomas Wade
wiley +1 more source
Métropoles, 2016 This article deals with the territorial impact of the process of agencification. By mobilizing the Urban Theory Regime Theory, we study in details the interactions between local stakeholders and agencies in the building of a local political capacity. The
Rémi Dormois
doaj +1 more source
Validity of a Wearable Digital Insole for Assessing Gait ON and OFF in Parkinson's Disease
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective Gait impairment is a distinctive symptom of Parkinson's disease that negatively impact mobility. We assessed the validity of wearable digital insoles against a validated reference gait analysis system for measuring select gait characteristics in patients with Parkinson's disease. Methods A comparative analysis between digital insoles
Deborah A. Hall +16 more
wiley +1 more source
An asymptotic problem in renewal theory
, 1972 A special problem in renewal theory is considered. The asymptotic behavior of the renewal function was studied by W. L. Smith. Here we show that his result with an exponentially small remainder term follows from a theorem of De Bruijn on Volterra ...
Klamkin, M.S., van Lint, J.H.
core +1 more source
LandUrban renewal is a critical approach to address issues such as the scarcity of urban spatial resources and infrastructure aging in the later stages of urbanization. Urban village renewal is one of the typical practices of urban renewal.
Jiaxi Xiao, Fan Dong
doaj +1 more source
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Background Emerging evidence suggests that low‐frequency neural oscillations are dynamically regulated by consciousness levels, with the recovery of low cortical activity potentially serving as a neurophysiological substrate for conscious emergence. Targeted enhancement of these low‐frequency rhythms in patients with disorders of consciousness
Chuan Xu +10 more
wiley +1 more source