Results 61 to 70 of about 9,545 (261)

Monopolistic Insurance and the Value of Information

Risks, 2015
The value of information regarding risk class for a monopoly insurer and its customers is examined in both symmetric and asymmetric information environments.
Arthur Snow
doaj   +1 more source

Genome‐Wide CRISPR Screen Identifies a microRNA Orchestrating Pleiotropic Resistance to Targeted Therapy and T Cell Immunity in Melanoma

Advanced Science, EarlyView.
A genome‐wide microRNA CRISPR screen identifies miR‐18a as a master regulator of cross‐resistance in melanoma. Loss of miR‐18a activates the AJUBA–YAP/Hippo axis to confer BRAFi resistance and enhances THBS1–CD47 interaction to impair CD8+ T cell immunity. hnRNP A1 is identified as an upstream regulator of miR‐18a processing.
Zhao Wang, Haotian Liu, Xueqi Wang, Jianjin Teng, Zihan Zheng, Jingya Zhang, Wanyi Xiao, Qian Liang, Jiaxin Li, Xiaomeng Jia, Xin Feng, Hongzhang Cui, Menghan Luo, Tielong Yang, Liuxing Wu, Ke Zhao, Weilong Yang, Mulin Jun Li, Dandan Huang, Jilong Yang   +19 more
wiley   +1 more source

Digital Identity: The effect of trust and reputation information on user judgement in the Sharing Economy.

PLoS ONE, 2018
The Sharing Economy (SE) is a growing ecosystem focusing on peer-to-peer enterprise. In the SE the information available to assist individuals (users) in making decisions focuses predominantly on community-generated trust and reputation information ...
Mircea Zloteanu, Nigel Harvey, David Tuckett, Giacomo Livan   +3 more
doaj   +1 more source

Mekanisme Keuangan dalam Struktur Modal Perusahaan

Asy-Syir'ah, 2008
There are several Islamic modes of financing which serve as alternatives to interest based financing. There is, however, divergence of views between theory and practice about the order of preference of these modes of financing.
Safaul Mudawam
doaj   +1 more source

Rent sharing as a driver of the glass ceiling effect [PDF]

Economics Letters, 2012
In this paper we show that rent sharing plays a role in explaining the glass ceiling effect. We make use of a unique employer-employee panel database for Italy from 1996 to 2003, which allows controlling for observed individual and firm heterogeneity and for collective bargaining.
Matano, Alessia, Naticchioni, Paolo
openaire   +8 more sources

HNRNPU K181 Lactylation Drives Cervical Cancer Growth by Upregulating PHGDH and Reprogramming Serine Metabolism

Advanced Science, EarlyView.
Lactate in cervical cancer induces HNRNPU K181 lactylation, opposed by NAA50‐mediated acetylation and suppressed by Pazopanib. This lactylation enhances HNRNPU binding to PHGDH pre‐mRNA exon 1, maintaining exon 1‐containing transcripts and mRNA stability, thereby activating serine metabolism.
Chang Zhang, Qingfei Meng, Hui Jiao, Huixin Liu, Xiangchao Wang, Honglan Zhou, Yishu Wang   +6 more
wiley   +1 more source

Navigating resistance on digital platforms: delivery and transportation labor in Türkiye

Frontiers in Sociology
Digital platforms are transforming the world of work. However, platforms operating in similar fields of activity encounter varying mechanisms of opposition, as a result of different degrees of professional institutionalization and their relations with ...
Batuhan Ersöz, Altan Başaran
doaj   +1 more source

Harnessing Phase Separation for the Development of High‐Performance Hydrogels

Advanced Science, EarlyView.
ABSTRACT Hydrogels are indispensable for the development of next‐generation bioelectronics, soft robotics, and biomedical devices, where their mechanical properties determine performance and reliability. Among strategies to enhance hydrogel mechanics, phase separation enables controlled heterogeneity resulting in gel networks that are reinforced by ...
Yue Shao, Yiming Ma, Baihao Shao, Molly M. Stevens   +3 more
wiley   +1 more source

Factors Determining the Adoption of Sharing Economy Models in the Travel Context [PDF]

Journal of Emerging Trends in Marketing and Management, 2018
Sharing economy options are business models where providers offer certain properties (homes, cars, etc.) or items for rent to others, usually through an intermediary platform.
Hande B. TURKER, V. Aslihan NASIR, Ulas Can ERGUNEY, Cagla SENOL   +3 more
doaj  

Targeting Dnmt3a/m5C/RelA Axis Attenuates Microglia Inflammatory Response and Improves Postoperative Recovery in Chronic Compressive Cervical Spinal Cord Injury

Advanced Science, EarlyView.
A pro‐inflammatory microglial subset persists after decompression in chronic compressive cervical spinal cord injury and shows enhanced Dnmt3a‐driven m5C signaling. By stabilizing RelA mRNA, this axis sustains NF‐κB activation and postoperative neuroinflammation.
Tianyu Qin, Yuan Jiang, Yongheng Xie, Huanwei Qu, Wenbin Yan, Jingle Chen, Yining Chen, Huayi Li, Naibo Feng, Jiajun Wu, Chao Zhang, Zhengqi Huang, Ming Shi, Zhihuai Deng, Guozhi Xiao, Houqing Long   +15 more
wiley   +1 more source