Results 101 to 110 of about 18,549 (301)

Intercellular Horizontal Transfer of TXNDC5 mRNA via Extracellular Vesicles Contributes to Tumor‐Associated Macrophage‐Mediated Prostate Cancer Metastasis

Advanced Science, EarlyView.
This study investigates the role of M2 macrophage‐derived extracellular vesicles (M2 EVs) in prostate cancer (PCa) metastasis. Mechanistically, M2 EVs horizontally transfer TXNDC5 mRNA to PCa cells, where the molecule induces the mesenchymal‐like state (MLS), enhancing PCa migration and invasion.
Cong Hu, Tianyang Wu, Jiayi Wang, Xinxing Du, Xinrui Wu, Yanhao Dong, Zehong Peng, Penghui Liao, Zirui Guo, Zheyu Liu, Kenneth J Pienta, Yinjie Zhu, Jiahua Pan, Liang Dong, Wei Xue   +14 more
wiley   +1 more source

CDK4/6 Inhibition Induces CD8+ T Cell Antitumor Immunity via MIF‐Induced Functional Orchestration of Tumor‐Associated Macrophages

Advanced Science, EarlyView.
CDK4/6 inhibition promotes CD8+ T cell expansion through tumor‐macrophage crosstalk by activating HIF‐1α and enhancing MIF‐CD44/CD74 signaling. This reprograms TAMs to boost MHC‐I antigen presentation, and CDK4/6 inhibitor‐trained M1 TAM supernatant therapy synergizes with low‐dose PD‐1 blockade to restore antitumor immunity.
Lin He, Yuzhong Peng, Lat‐lun Leong, Jingbo Zhou, Dongyang Tang, Weilu Wang, Xiaoran Wu, Josh haipeng Lei, Yongqin Ye, Yangyang Feng, Yunfeng Qiao, Xiangpeng Chu, Di Mu, Qi Zhao, Tzuming Liu, Yan Chen, Paul Kwonghang Tam, Chu‐Xia Deng   +17 more
wiley   +1 more source

STUDIES ON CLINICAL EFFICACY OF SOME THERAPEUTIC REGIMENS FOR THE MANAGEMENT OF ENDOMETRITIS IN COWS [PDF]

Exploratory Animal and Medical Research, 2018
A total of 124 cows were treated with various therapeutic regimens by different routes. In the first group, Ciprofloxacin was administered through intrauterine route with clinical recovery of 87.88 percent and were inseminated in subsequent estrus with
Madhumeet Singh, Amit Sharma, Pravesh Kumar, Neelam Bhardwaj, Akshay Sharma, ndu Bala   +5 more
doaj  

Detection of bacterial biofilm in uterine of repeat breeder dairy cows

Asian Pacific Journal of Reproduction, 2017
Objective: To determine the possibility of presence of bacterial biofilm in the uterus of repeat breeder cows and to evaluate the effect of mucolytic agent in cleanup of uterus from biofilm.Methods: Twenty repeat breeder cows were selected from a large ...
Mohammad Rahim Ahmadi, Abdollah Derakhshandeh, Sadegh Shirian, Yahya Daneshbod, Maryam Ansari-Lari, Saeid Nazifi   +5 more
doaj   +1 more source

Precision Editing of NLRS Improves Effector Recognition for Enhanced Disease Resistance

Advanced Science, EarlyView.
Precision engineering of plant NLR immune receptors enables rational design of enhanced pathogen resistance through mismatched pairing, domain swapping, and targeted mutagenesis. These approaches achieve multi‐fold expansion in recognition breadth while minimizing autoimmunity risks and fitness penalties.
Vinit Kumar, Vishwa I. P. W. A. Kumara, Pradeepa C. G. Bandaranayake, Dong Yawen, Yang‐Yang Gao, Junfeng Liu, Ge‐Fei Hao, Xiu‐Fang Xin   +7 more
wiley   +1 more source

Adenylyl Cyclase 8 in Dorsal CA1 Neurons Prevents Depressive‐Like Behaviors by Maintaining Neuronal Excitability and Glutamatergic Neurotransmission Through TIP39‐PTH2R Signaling

Advanced Science, EarlyView.
Depression, a prevalent neuropsychiatric disorder with unclear pathogenesis, involves dysfunctional adenylyl cyclase 8 (Adcy8) as a key risk factor. Chronic stress selectively reduces Adcy8 expression in the dorsal CA1 (dCA1) neurons. Depletion of Adcy8 in dCA1 excitatory neurons induces depressive‐like behaviors by impairing neuronal excitability and ...
Zi‐Jie Liu, Jia‐Rui Bi, Zong‐Yan Yu, Meng Tian, Zhi‐Yue Chen, Ran Wei, Miao‐Miao Wang, Hai‐Wei Zha, Yu‐Qing Zhang, Hong‐Jing Wang, Bang‐You Qiang, Shuang‐Shuang Sun, Xiao‐Juan Zhu, Wen‐Bing Chen, Dong Sun   +14 more
wiley   +1 more source

Genetic structure of some candidate genes of repeat breeder syndrome in Egyptian buffaloes. [PDF]

J Genet Eng Biotechnol, 2022
Mahrous KF, El-Kader HAMA, Abdelhafez MA, Aboelenin MM, Balabel EA, Mabrouk DM, El Malky OM, Hassanane MS.   +7 more
europepmc   +1 more source

A NONLINEAR MODEL OF INFORMATION AND COORDINATION IN HOG PRODUCTION: TESTING THE COASIAN-FOWLERIAN DYNAMIC HYPOTHESES [PDF]

The pig-cycle 'explanation' expunded by Coase and Fowler followed a well-integrated economic logic and provides tremendous insight into our understanding of commodity cycles. The paper presents a simulation model that replicates all of Coase and Fowler's
Cloutier, L. Martin, Garcia, Philip, Ruth, Matthias   +2 more
core   +1 more source

Commercial Beef Cow Herds in Ohio [PDF]

, 1955
PDF pages ...
Warner, James Hubert
core  

Structure‐Based Development of Ultra‐Broad‐Spectrum 3C‐Like Protease Inhibitors

Advanced Science, EarlyView.
This study provides an in‐depth analysis of the substrate binding pocket of 3CLpros across all coronavirus species using bioinformatics and structural insights, revealing the critical impact of S2/S4 subsite diversity on the broad‐spectrum activity of approved therapeutics.
Haixia Su, Tianqing Nie, Guofeng Chen, Muya Xiong, Yumin Zhang, Guoqing Wu, Mengyuan You, Hang Xie, Jian He, Yanchao Xiong, Hangchen Hu, Wenfeng Zhao, Minjun Li, Gengfu Xiao, Leike Zhang, Yechun Xu   +15 more
wiley   +1 more source