Results 41 to 50 of about 52,949 (237)

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

Molecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son, Lily L. Remsing Rix, Bin Fang, Eric A. Welsh, Nicole V. Bremer, Valentina Foglizzo, Paola Roa, Nickole Sigcha‐Coello, Yi Liao, Eric B. Haura, Alexander Drilon, John M. Koomen, Emiliano Cocco, Uwe Rix   +13 more
wiley   +1 more source

Influence of controlled breeding techniques on fertility and plasma progesterone, protein and cholesterol profile in true anestrus and repeat breeding buffaloes [PDF]

Veterinary World, 2014
Aim: The aim was to evaluate the estrus response, conception rate and plasma profile of progesterone, protein and cholesterol following use of different hormonal protocols in anestrus and repeat breeding buffaloes.
K. K. Savalia, A. J. Dhami, K. K. Hadiya, K. R. Patel , N. P. Sarvaiya   +4 more
doaj   +1 more source

Methylation biomarkers can distinguish pleural mesothelioma from healthy pleura and other pleural pathologies

Molecular Oncology, EarlyView.
We developed and validated a DNA methylation–based biomarker panel to distinguish pleural mesothelioma from other pleural conditions. Using the IMPRESS technology, we translated this panel into a clinically applicable assay. The resulting two classifier models demonstrated excellent performance, achieving high AUC values and strong diagnostic accuracy.
Janah Vandenhoeck, Nele De Meulenaere, Thomas Vanpoucke, Joe Ibrahim, Dieter Peeters, Suresh Krishan Yogeswaran, Wen Wen, Paul Van Schil, Jeroen M. H. Hendriks, Jo Raskin, Jan van Meerbeeck, Guy Van Camp, Ken Op de Beeck   +12 more
wiley   +1 more source

Evidence of epistatic suppression of repeat fruiting in cultivated strawberry

BMC Plant Biology, 2019
Background Consumers purchase fresh strawberries all year long. Extending the fruiting season for new strawberry cultivars is a common breeding goal. Understanding the inheritance of repeat fruiting is key to improving breeding efficiency.
K. S. Lewers, P. Castro, J. F. Hancock, C. K. Weebadde, J. V. Die, L. J. Rowland   +5 more
doaj   +1 more source

Reproductive Efficiency Of Dairy Cows With Repeat Breeding

Jurnal Sains dan Teknologi Industri Peternakan, 2021
Salah satu gangguan reproduksi yang banyak terjadi di Peternakan sapi perah, yaitu kawin berulang (Repeat Breeding). Tujuan penelitian ini adalah untuk melihat efisiensi reproduksi induk sapi perah yang mengalami kawin berulang. Penelitian ini dilakukan secara survei dengan pengumpulan data primer dan sekunder.
openaire   +2 more sources

Blood Biochemical Profile in Madura Cows with Repeated Breeding

, 2023
This research aims to identify the biochemical profile of blood in Madura cattle that have experienced repeated breeding. There are ten female cows divided into two groups. In the first group, five cows are being mated repeatedly. The second one has five fertile cows.
Da Costa Freitas, Joana, Diah Tri Widayati, Yusiati, Lies Mira   +2 more
openaire   +1 more source

Perspectives in educating molecular pathologists on liquid biopsy: Toward integrative, equitable, and decentralized precision oncology

Molecular Oncology, EarlyView.
Liquid biopsy enables minimally invasive, real‐time molecular profiling through analysis of circulating biomarkers in biological fluids. This Perspective highlights the importance of training pathologists through integrative educational programs, such as the European Masters in Molecular Pathology, to ensure effective and equitable implementation of ...
Marius Ilié, Umberto Malapelle, Catherine Alix‐Panabières, Claus Lindbjerg Andersen, Sandra Chlebowski, Vivien Lake, Caroline Lacoux, Virginie Lespinet‐Fabre, Olivier Bordone, Simon Heeke, Christophe Bontoux, Ellen Heitzer, Klaus Pantel, Paul Hofman   +13 more
wiley   +1 more source

Estrus quality, non-return rate and conception rate in the incidence of repeat breeding in dairy cow after 2%povidone iodine therapy combined with prostaglandin F2α at KUD Tani Wilis Tulungagung

Ovozoa: Journal of Animal Reproduction
Repeat breeding is a condition in which cows fail to conceive after being bred three or more times. This study aims to determine the quality of estrus, non-return rate (NRR) and conception rates obtained after cows were treated with 2% povidone iodine ...
Amira Halimah Zahrorona, Sri Pantja Madyawati, Pudji Srianto, Hermin Ratnani, Sunaryo Hadi Warsito, Sri Hidanah   +5 more
doaj   +1 more source

FERTILITY FOLLOWING OESTRUS INDUCTION USING PGF2a AND TREATMENT WITH GnRH AND hCG IN REPEAT BREEDING CATTLE SHOWING PROLONGED OESTRUS [PDF]

Journal of Veterinary and Animal Sciences, 2006
The trial was conducted to evaluate the fertility o; repeat breeding cattle showing prolonged oestrus after induction using dinoprost and further treatment with GnRH and hCG.
G. Jeba Sujana Dhas, K.N. Aravinda Ghosh, T. Sreekumaran   +2 more
doaj  

Crucial parameters for precise copy number variation detection in formalin‐fixed paraffin‐embedded solid cancer samples

Molecular Oncology, EarlyView.
This study shows that copy number variations (CNVs) can be reliably detected in formalin‐fixed paraffin‐embedded (FFPE) solid cancer samples using ultra‐low‐pass whole‐genome sequencing, provided that key (pre)‐analytical parameters are optimized.
Hanne Goris, Vasiliki Siozopoulou, Léon C van Kempen, Anne Sieben, Ella Roelant, Stig Hellemans, Elyne Backx, Laure Sorber, Koen De Winne, Senada Koljenović, Karen Zwaenepoel   +10 more
wiley   +1 more source