Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
A Variable Polyglutamine Repeat Affects Subcellular Localization and Regulatory Activity of a Populus ANGUSTIFOLIA Protein. [PDF]
, 2018 Polyglutamine (polyQ) stretches have been reported to occur in proteins across many organisms including animals, fungi and plants. Expansion of these repeats has attracted much attention due their associations with numerous human diseases including ...
Barry, Kerrie +12 more
core +1 more source
Aggressive prostate cancer is associated with pericyte dysfunction
Molecular Oncology, EarlyView.Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero +11 more
wiley +1 more source
Evidence of epistatic suppression of repeat fruiting in cultivated strawberry
BMC Plant Biology, 2019 Background Consumers purchase fresh strawberries all year long. Extending the fruiting season for new strawberry cultivars is a common breeding goal. Understanding the inheritance of repeat fruiting is key to improving breeding efficiency.
K. S. Lewers +5 more
doaj +1 more source
Molecular Genetic Diversity Study of Forest Coffee Tree (Coffea arabica L.) Populations in Ethiopia: Implications for Conservation and Breeding [PDF]
, 2005 Coffee provides one of the most widely drunk beverages in the world, and is a very important source of foreign exchange income for many countries. Coffea arabica, which contributes over 70 percent of the world's coffee productions, is characterized by a ...
Aga, Esayas
core
Surviving a Genome Collision: Genomic Signatures of Allopolyploidization in the Recent Crop Species [PDF]
, 2017 Polyploidization has played a major role in crop plant evolution, leading to advantageous traits that have been selected by humans. Here, we describe restructuring patterns in the genome of Brassica napus L., a recent allopolyploid species.
Chalhoub, Boulos +2 more
core +1 more source
Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells
Molecular Oncology, EarlyView.Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son +13 more
wiley +1 more source
Systemic levels of iron, phosphorus, and total protein in normocyclic versus repeat breeder Holstein Friesian crossbred cows of Kesharbag, Chitwan, Nepal [PDF]
Veterinary World, 2020 Background and Aim: In repeat breeding, a sexually mature cow fails to conceive even after three or more consecutive inseminations despite being without any clinically detectable reproductive anomalies. This is a major cause of economic loss in livestock
Girija Regmi, Ishwari Prasad Dhakal
doaj +1 more source
KAJIAN FAKTOR RESIKO REPEAT BREEDING SEBAGAI UPAYA PERBAIKAN POTENSI REPRODUKSI SAPI ACEH BETINA (STUDI KASUS DI KABUPATEN PIDIE) [PDF]
, 2016 RINGKASANDJOKO SUBAGYO.Kajian faktor resiko repeat breeding sebagai upayaperbaikan potensi reproduksi sapi aceh betina (studi kasus di KabupatenPidie). TONGKU NIZWAN SIREGAR.
DJOKO SUBAGYO
core
Natural history of Arabidopsis thaliana and oomycete symbioses [PDF]
, 2008 Molecular ecology of plant–microbe interactions has immediate significance for filling a gap in knowledge between the laboratory discipline of molecular biology and the largely theoretical discipline of evolutionary ecology.
A. Falk +87 more
core +2 more sources