Results 111 to 120 of about 2,168,210 (298)

When Negative Turns Positive and Vice Versa: The Case of Repeated Measurements

Health Professions Education, 2019
Background: In increasing numbers of studies, participants are measured on the same variables of interest – such as task performance and effort associated with task performance – several times.
Jimmie Leppink
doaj   +1 more source

Decoherence due to discrete noise in Josephson qubits

, 2003
We study decoherence produced by a discrete environment on a charge Josephson qubit by introducing a model of an environment of bistable fluctuators. In particular we address the effect of $1/f$ noise where memory effects play an important role.
A D'Arrigo, Bauernschmitt, E Paladino, G Falci, L Faoro, Makhlin, Makhlin, Nakamura, Nakamura, Nielsen, Paladino, Shnirman, Vion, Weissman, Zorin, Zurek   +15 more
core   +1 more source

Epigenetic blind spots – the role of DNA methylation dynamics in stem cell‐based models of embryogenesis

FEBS Letters, EarlyView.
Embryo‐like structures (stembryos) are an innovative tool, but they are hindered by experimental variability and limited developmental potential. DNA methylation is crucial for mammalian development, but its status in stembryo models is poorly characterized.
Sara Canil, Anna Corrà, Annalisa Scapolatiello, Chengxiang Qiu, Gianluca Amadei   +4 more
wiley   +1 more source

Acute Coronary Syndrome Subphenotypes Based on Repeated Biomarker Measurements in Relation to Long‐Term Mortality Risk

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Background We aimed to identify patients with subphenotypes of postacute coronary syndrome (ACS) using repeated measurements of high‐sensitivity cardiac troponin T, N‐terminal pro‐B‐type natriuretic peptide, high‐sensitivity C‐reactive protein, and ...
Marie de Bakker, Niels T. B. Scholte, Rohit M. Oemrawsingh, Victor A. Umans, Bas Kietselaer, Carl Schotborgh, Eelko Ronner, Timo Lenderink, Ismail Aksoy, Pim van der Harst, Folkert W. Asselbergs, Arthur Maas, Anton J. Oude Ophuis, Boudewijn Krenning, Robbert J. de Winter, S. Hong Kie The, Alexander J. Wardeh, Walter Hermans, G. Etienne Cramer, Ron H. van Schaik, Yolanda B. de Rijke, K. Martijn Akkerhuis, Isabella Kardys, Eric Boersma   +23 more
doaj   +1 more source

pH‐mediated activation of the lysosomal arginine sensor SLC38A9

FEBS Letters, EarlyView.
Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley   +1 more source

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

Pneumocystis pneumonia diagnosed by repeated measurements of β-D-glucan levels. [PDF]

Respir Med Case Rep, 2023
Kawasaki Y, Kozaneyori A, Suda T, Yamamoto K, Kuwahara D, Yoshio T, Shintaku H, Matsumoto H.   +7 more
europepmc   +1 more source

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source

Modelación de indicadores del estado nutricional de la embarazada desde un enfoque multinivel

Revista Colombiana de Estadística, 2012
Se presenta una estrategia para la construcción de indicadores antropométricos empleados para evaluar el estado nutricional de la mujer embarazada. Las referencias del peso por semana de embarazo, según la estatura y el índice de masa corporal de la ...
MINERVA MONTERO, MARIA ELENA DÍAZ, SANTA JIMÉNEZ, IRAIDA WONG, VILMA MORENO   +4 more
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