Results 151 to 160 of about 4,206,856 (305)

Human Health Effects of Chronic Microcystin Exposure: A Systematic Review and Meta-Analysis of Hepatic, Renal, and Metabolic Outcomes. [PDF]

Toxins (Basel)
Moon SD, Hwang DS, Lee JS, Hwang SO, Paerl HW, Kim BH.   +5 more
europepmc   +1 more source

Cyclic azapeptide CD36 ligand attenuates cardiac injury and reduces long‐chain fatty acid accumulation after myocardial ischemia–reperfusion in mice

FEBS Open Bio, EarlyView.
In a murine model of myocardial ischemia and reperfusion (MI/R), the CD36 azapeptide ligand MPE‐298 reduces cardiac injury and transiently lowers left ventricular long‐chain fatty acids (LCFAs) accumulation 3 h after reperfusion, accompanied by a decrease of oxidative stress and inflammation‐associated genes' expression in the heart and adipose tissue.
Jade Gauvin, Naghme Radmannia, David N. Huynh, Liliane Ménard, Caroline Daneault, Maïté Veilleux, Ahsanullah Ahsanullah, André C. Carpentier, William D. Lubell, Matthieu Ruiz, Huy Ong, Sylvie Marleau, Simon‐Pierre Gravel   +12 more
wiley   +1 more source

Sample size determination across study designs in health professions education research: a methodology guide. [PDF]

F1000Res
Naqvi WM, Divvi A, Kengadaran S, Pashine AA, Baladaniya M, Patel A, Kandakurthi PK, Muthukrishnan R.   +7 more
europepmc   +1 more source

Hydrostatic pressure activates HIF‐1α via β‐catenin to promote stemness in breast cancer cells

FEBS Open Bio, EarlyView.
To mimic the elevated intestinal fluid pressure in breast cancers, we loaded human breast cancer cells (MCF‐7, MDA‐MB‐453, and BT‐474) to 50 mmHg hydrostatic pressure. Hydrostatic pressure exposure upregulated HIF‐1α and induced stemness in MCF‐7 and BT‐474 cells.
Da Zhai, Yong Xu, Jingjing Ma, Ratchanee Duangrat, Chen Yan, Jingyan Liang, Hua Wei, Bin Jiang, Tao‐Sheng Li   +8 more
wiley   +1 more source

Combinatorial Designs with Two Singular Values I. Uniform Multiplicative Designs [PDF]

In this and a sequel paper [10] we study combinatorial designs whose incidence matrix has two distinct singular values.These generalize 2-(v, k, É) designs, and include partial geometric designs and uniform multiplicative designs.Here we study the latter,
Spence, E., Dam, E.R. van
core  

Comparative numerical and experimental evaluation of 3D-printed micromixers for biotechnological applications. [PDF]

Sci Rep
Mengele M, Zürn J, Lochner T, Weiß U, Peter MA, Bahnemann J, Heuer C.   +6 more
europepmc   +1 more source

Directed evolution of enzymes at the crossroads of tradition and innovation

FEBS Open Bio, EarlyView.
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova, Andrej Mirossay, Erik Sedlak   +2 more
wiley   +1 more source

Combinatorial Designs with Two Singular Values II. Partial Geometric Designs [PDF]

In this and an earlier paper [17] we study combinatorial designs whose incidence matrix has two distinct singular values.These generalize (v, k, ë) designs, and include uniform multiplicative designs and partial geometric designs.Here we study the latter,
Spence, E., Dam, E.R. van
core  

Digital N-of-1 trials and their application in experimental physiology. [PDF]

Exp Physiol
Konigorski S, Ried-Larsen M, Schmid CH.
europepmc   +1 more source

Molecular characterization of covRS mutations in M1UK Streptococcus pyogenes

FEBS Open Bio, EarlyView.
Group A Streptococcus (GAS) acquires covRS mutations driving a hypervirulent bacterial state, frequently associated with invasive disease‐like necrotizing fasciitis. We demonstrate that the newly emerged M1UK GAS lineage can also acquire these mutations.
Jarrad Pritchard, Emma‐Jayne Proctor, Jiawa Wang, Nikolas P. Johnston, Andrew Hayes, Georgia McCorkell, Haibo Yu, Jai Tree, Mark R. Davies, Mark J. Walker, Ronald Sluyter, Stephan Brouwer, Martina L. Sanderson‐Smith   +12 more
wiley   +1 more source