Modeling hepatic fibrosis in TP53 knockout iPSC‐derived human liver organoids
Molecular Oncology, EarlyView.This study developed iPSC‐derived human liver organoids with TP53 gene knockout to model human liver fibrosis. These organoids showed elevated myofibroblast activation, early disease markers, and advanced fibrotic hallmarks. The use of profibrotic differentiation medium further amplified the fibrotic signature seen in the organoids.
Mustafa Karabicici +8 more
wiley +1 more source
Changes in Mental Health and Views on Communication and Activities of Public Institutions among Swedes during the COVID-19 Pandemic-A Cross-Sectional Repeated Measures Design. [PDF]
Healthcare (Basel), 2021 Kerstis B +6 more
europepmc +1 more source
[Multivariate repeated measures designs].
Psicothema, 2007 In the social, behavioral, and health researches it is a common strategy to collect data along time on more than one group of participants on multiple dependent variables. To analyse this kind of data is very complicated due to the correlations between the measures taken in different points of the time, and between the answers. Usually to analyse these
Guillermo, Vallejo, Luis M, Lozano
openaire +1 more source
Stages of Change in the Trajectory of Postpartum Weight Self-Management [PDF]
, 2012 Objective To identify women\u27s patterns of readiness to engage in weight self-management behaviors during the postpartum period. Design Prospective, longitudinal design with repeated measures, guided by the transtheoretical model of behavior change ...
Ohlendorf, Jennifer M.
core +1 more source
Molecular Oncology, EarlyView.Following high dose rate brachytherapy (HDR‐BT) for hepatocellular carcinoma (HCC), patients were classified as responders and nonresponders. Post‐therapy serum induced increased BrdU incorporation and Cyclin E expression of Huh7 and HepG2 cells in nonresponders, but decreased levels in responders.
Lukas Salvermoser +14 more
wiley +1 more source
Combinatorial problems in repeated measurements designs
Discrete Mathematics, 1989 In the recent past a number of papers on design of experiments have considered the structure of designs with certain desirable properties. In a repeated measurements designs (RMD) there are t treatments, n experimental units and the experiment lasts for p periods. Each experimental unit receives one treatment during each period.
openaire +2 more sources
Increased Lower Limb Spasticity but Not Strength or Function Following a Single-Dose Serotonin Reuptake Inhibitor in Chronic Stroke [PDF]
, 2015 Objective: To investigate the effects of single doses of a selective serotonin reuptake inhibitor (SSRI) on lower limb voluntary and reflex function in individuals with chronic stroke. Design: Double-blind, randomized, placebo-controlled crossover trial.
Gourab, Krishnaj +2 more
core +1 more source
Inhibition of CDK9 enhances AML cell death induced by combined venetoclax and azacitidine
Molecular Oncology, EarlyView.The CDK9 inhibitor AZD4573 downregulates c‐MYC and MCL‐1 to induce death of cytarabine (AraC)‐resistant AML cells. This enhances VEN + AZA‐induced cell death significantly more than any combination of two of the three drugs in AraC‐resistant AML cells.
Shuangshuang Wu +18 more
wiley +1 more source
Effect of Psychostimulant Medications on Muscle Tone in Adults with Attention Deficit Hyperactivity Disorder: Within-Subject Repeated-Measure Study Design [PDF]
, 2022 Mansour M. Alotaibi +5 more
openalex +1 more source
Molecular Oncology, EarlyView.This study characterizes the responses of primary acute myeloid leukemia (AML) patient samples to the MCL‐1 inhibitor MIK665. The results revealed that monocytic differentiation is associated with MIK665 sensitivity. Conversely, elevated ABCB1 expression is a potential biomarker of resistance to the treatment, which can be overcome by the combination ...
Joseph Saad +17 more
wiley +1 more source