Results 41 to 50 of about 1,867,213 (332)

phase1RMD: An R package for repeated measures dose-finding designs with novel toxicity and efficacy endpoints.

PLoS ONE, 2021
Traditional dose-finding designs are substantially inefficient for targeted agents and cancer immunotherapies by failing to incorporate efficacy signals, mild and moderate adverse events, and late, cumulative toxicities.
Jun Yin, Yu Du, Rui Qin, Shihao Shen, Sumithra Mandrekar   +4 more
doaj   +1 more source

Impact of foot progression angle modification on plantar loading in individuals with diabetes mellitus and peripheral neuropathy [PDF]

, 2016
AIMS: To determine if participants can reduce foot progression angle (FPA), and if FPA reduction decreases regional plantar stresses and forces in individuals with diabetes.
Bohnert, Kathryn L, Hastings, Mary K, Hollman, John H, Merriwether, Ericka N, Sinacore, David R, Strube, Michael J   +5 more
core   +2 more sources

Sickle Cell Disease Is an Inherent Risk for Asthma in a Sibling Comparison Study

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Introduction Sickle cell disease (SCD) and asthma share a complex relationship. Although estimates vary, asthma prevalence in children with SCD is believed to be comparable to or higher than the general population. Determining whether SCD confers an increased risk for asthma remains challenging due to overlapping symptoms and the ...
Suhei C. Zuleta De Bernardis, Okeleji Olayinka, Mariam Z. Quraishi, Lakshmi V. Srivaths, Deborah L. Brown, Neethu M. Menon, Ricardo A. Mosquera, Ashwin P. Patel, James M. Stark, Aravind Yadav   +9 more
wiley   +1 more source

Pazopanib Combined With Vincristine and Irinotecan in Relapsed Wilms Tumor: Encouraging Outcomes in a Heavily Pretreated Pediatric Cohort

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background While Wilms tumor (WT) typically has a favorable prognosis, relapsed cases—especially those with high‐risk histology—remain therapeutically challenging after intensive frontline therapy. The combination of vincristine and irinotecan has demonstrated activity in pediatric solid tumors, and pazopanib, a multi‐targeted tyrosine kinase ...
Maria Debora De Pasquale, Alessandro Crocoli, Giuseppe Maria Milano, Pierluigi Di Paolo, Francesca Diomedi Camassei, Ida Russo, Annalisa Serra   +6 more
wiley   +1 more source

Analysis of Covariance For Repeated Measures Design with Missing Observations [PDF]

, 1986
analysis of covariance might be one of the most miS4nderstood and inadequately taught of all applied statistical methods. Many methods books do not deQl with it at all (Cullman et. aI., 1982), or sparingly (Brownlee, J965), and most of those that treat
Alwi, Ahmad, Monlezun, C. J.
core  

Psychosocial Outcomes in Patients With Endocrine Tumor Syndromes: A Systematic Review

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Introduction The combination of disease manifestations, the familial burden, and varying penetrance of endocrine tumor syndromes (ETSs) is unique. This review aimed to portray and summarize available data on psychosocial outcomes in patients with ETSs and explore gaps and opportunities for future research and care.
Daniël Zwerus, Floortje Strobbe, Annemarie A. Verrijn Stuart, Hanneke M. van Santen, Gerlof D. Valk, Sasja A. Schepers, Rachel S. van Leeuwaarde   +6 more
wiley   +1 more source

An Interdisciplinary Examination of Stress and Injury Occurrence in Athletes

Frontiers in Sports and Active Living, 2020
This paper adopts a novel, interdisciplinary approach to explore the relationship between stress-related psychosocial factors, physiological markers and occurrence of injury in athletes using a repeated measures prospective design.
Harry Fisher, Marianne JR Gittoes, Lynne Evans, C Leah Bitchell, Richard J Mullen, Marco Scutari   +5 more
doaj   +1 more source

Sample Size Calculation and Power Analysis of Time-Averaged Difference [PDF]

, 2005
Little research has been done on sample size and power analysis under repeated measures design. With detailed derivation, we have shown sample size calculation and power analysis equations for timeaveraged difference to allow unequal sample sizes between
Liu, Honghu, Wu, Tongtong
core   +2 more sources

Nutritional and Behavioral Intervention for Long‐Term Childhood Acute Leukemia Survivors With Metabolic Syndrome

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Purpose Metabolic syndrome (MetS) is a common complication in survivors of childhood acute lymphoblastic and myeloid leukemia (AL), and a major risk factor for premature cardiovascular disease, type‐2‐diabetes, and metabolic dysfunction‐associated steatotic liver disease (MASLD).
Visentin Sandrine, Béliard Sophie, Renard Cécile, Caussy Cyrielle, Hamidou Zeinab, Romano David, Gacem Mélanie, Petit Arnaud, Saultier Paul, Borentain Patrick, Michel Gérard   +10 more
wiley   +1 more source

Comparing the Relative Efficacy of Generalized Estimating Equations, Latent Growth Curve Modeling, and Area Under the Curve with a Repeated Measures Discrete Ordinal Outcome Variable

Stats
Researchers are often interested in how changes in one variable influence changes in a second variable, requiring the repeated measures of two variables.
Daniel Rodriguez, Ryan Verma, Juliana Upchurch   +2 more
doaj   +1 more source