Results 31 to 40 of about 53,431 (251)

Analysing repeated hospital readmissions using data mining techniques [PDF]

Health Systems, 2017
Few studies have examined how to identify future readmission of patients with a large number of repeat emergency department (ED) visits. We explore 30-day readmission risk prediction using Microsoft's AZURE machine learning software and compare five classification methods: Logistic Regression, Boosted Decision Trees (BDTs), Support Vector Machine (SVM),
Ofir, Ben-Assuli, Rema, Padman
openaire   +4 more sources

Underground borehole-based grouting and filling technology to overburden separation induced by repeated mining for ground subsidence control

Meikuang Anquan, 2022
Overburden separation layer filling technology for ground surface subsidence control is an important part in the system of coal mine green mining. In this study, by considering the overburden structure and ground surface subsidence law, we propose a ...
ZHENG Lijun
doaj   +1 more source

Sudden change mechanism of mine pressure in fully mechanized caving face and its countermeasures

Meikuang Anquan, 2022
In view of the sudden change of mine pressure in 226 upper 02 fully mechanized caving face of Huangyuchuan Coal Mine, the mechanism and countermeasures of sudden change of mine pressure in fully mechanized caving face are studied by using the methods of
LI Yong, WANG Zhuoying
doaj   +1 more source

Evolution of mining−induced fractures and surface subsidence characteristics in shallow−buried multi−seam conditions: a case study of Wuda mining area

Meitan kexue jishu
Aiming at the complex overburden fracture development and repeated surface disturbance induced by multi-seam repeated mining, a shallow-buried multi-seam working face was selected as the research object. Based on discrete element method (DEM) simulations,
Yi TAN, Yuhang CUI, Wenbing GUO, Shaopu ZHANG, Yu WANG, Hao CHENG, Weiyu GUO, Shuai ZHANG   +7 more
doaj   +1 more source

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

Determining the Boundaries of Overlying Strata Collapse Above Mined-Out Panels of Zhomart Mine Using Seismic Data

Geosciences
The present article is devoted to the issue of studying the patterns of displacement of superincumbent rock over panels of a mine obtained using advanced seismic technologies, allowing for the study of the boundaries of caving zones in the depths of rock
Sara Istekova, Alexander Makarov, Dina Tolybaeva, Arman Sirazhev, Kuanysh Togizov   +4 more
doaj   +1 more source

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

Research on Formation Mechanism and Evolution Pattern of Bed Separation Zone during Repeated Mining in Multiple Coal Seams

Geofluids, 2022
Mastering the formation mechanism and dynamic evolution pattern of bed separation zone during repeated mining is the key to the success or failure of separation grouting injection technology. Taking a mine in Ningdong as the engineering background, using
Jianshuai Ji, Zhihua Li, Ke Yang, Guanghua Zhou, Guojun Ma, Cheng Liu, Peng Zhou   +6 more
doaj   +1 more source

Instability Control of Roadway Surrounding Rock in Close-Distance Coal Seam Groups under Repeated Mining

Energies, 2021
In order to solve the problems of roadway stability and easy instability under repeated mining of close-distance coal seam groups, the mechanism and control technology of surrounding rock instability under repeated mining were studied via indoor testing,
Yu Xiong, Dezhong Kong, Zhanbo Cheng, Zhijie Wen, Zhenqian Ma, Guiyi Wu, Yong Liu   +6 more
doaj   +1 more source

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

Molecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi, Mandy Berndt‐Paetz, Eileen Lerner, Gregoire Najjar, Anca Azoitei, Krishna Pal Singh, Shailendra Kumar Gupta, Olaf Wolkenhauer, Cagatay Günes, Otmar Huber, Marc‐Oliver Grimm, Daniel Steinbach   +11 more
wiley   +1 more source