Results 101 to 110 of about 24,142 (282)

AARS1‐Mediated H3K27 Lactylation Rewires Glycolysis to Sustain Aggressive and Recurrent Bladder Cancer

open access: yesAdvanced Science, EarlyView.
AARS1 drives PI3K–AKT–mTOR‐dependent glycolysis in bladder cancer, promoting lactate accumulation, increased lactylation, H3K27la enrichment at the HK2 promoter, and HK2 transcription. HK2 reinforces glycolysis, sustaining a metabolic–epigenetic program associated with tumor progression, recurrence, and metastasis.
Qin Yuan   +13 more
wiley   +1 more source

Carmelo Bene

open access: yesDrammaturgia, 2018
This paper reconstructs the life and works of one of the greatest exponents of the second half of the 20th century theatrical scene, an artist of international fame and prominence.
Emanuela Agostini
doaj  

A Dual‐Membrane Biomimetic Nanoplatform Enables Triple‐Modal Therapy Against SARS‐CoV‐2 Through Viral Decoy, Inflammation Neutralizing, and Intracellular RNAi

open access: yesAdvanced Science, EarlyView.
[A&T]MLN is a triple‐modal nanoplatform with siRNA‐loaded LN coated with hybrid ACE2/macrophage membrane. It blocks viral entry, neutralizes IL‐6/IL‐1β/TNF‐α, and delivers siRNA to suppress viral replication. In a murine lung injury model, it attenuates inflammation, offering a multi‐pronged strategy against SARS‐CoV‐2 variants and hyperinflammation ...
Hui Li   +19 more
wiley   +1 more source

Francesco Saverio Bartoli

open access: yesDrammaturgia, 2017
A modestly talented actor and playwright, Bartoli acted with his wife Teodora Medebach in the theatre company directed by Antonio Sacco from 1771 to 1777. Sick with tuberculosis, he precociously retired from the stage to become a bookseller. He is renown
Leonardo Spinelli
doaj  

Functional–Taxonomic Scaling Resolves Conflicting Average Genome Size Estimates Across Environmental Gradients

open access: yesAdvanced Science, EarlyView.
Based on genome size‐functional breadth theory, we introduce and validate a framework that adjudicates conflicting average genome size (AGS) estimates by testing which estimate yields a gap between scaled functional diversity and scaled taxonomic diversity that is consistent with the expected positive association between genome size and gene functional
Huanhuan Zhu   +8 more
wiley   +1 more source

Amalia Bettini

open access: yesDrammaturgia, 2016
‘Amorosa’, then leading actress, the most appreciated and sought after actress of the 1830s. She had an intense and longstanding relationship with the poet Giuseppe Gioachino Belli.
Daniela Sarà
doaj  

Phase Separation of SF3B1 Serves as a Critical Post‐Transcriptional Regulator During Early Mouse Embryogenesis

open access: yesAdvanced Science, EarlyView.
Phase separation of SF3B1 acts as a key regulatory mechanism for dynamic alternative splicing throughout early mouse embryogenesis. Its absence triggers extensive splicing errors, which induce persistent DNA damage, defective cell cycle progression, and failed cell lineage commitment, and ultimately hinder the normal growth and development of ...
Kang Zhao   +15 more
wiley   +1 more source

Carlotta Marchionni

open access: yesDrammaturgia, 2016
Born into an acting family, she began her career in companies in Tuscany. She gained her first leading actress role in 1811 in the troupe run by her mother, Elisabetta, and by Antonio Belloni, Carlo Calamari and Ferdinando Meraviglia.
Francesca Simoncini, Antonio Tacchi
doaj  

Single‐Cell Profiling Reveals Clonally Expanded CX3CR1+ T Cells in Anti‐NMDA Receptor Encephalitis

open access: yesAdvanced Science, EarlyView.
CX3CR1+ T cells are associated with peripheral and central immune alterations in anti‐NMDA receptor encephalitis (NMDAR‐E). They show potential responsiveness to GluN1 (NR1) peptides, potential interactions with peripheral B cells, clonal expansion, increased CD137/CD154 expression, and inflammatory cytokine production. Their preferential cerebrospinal
Lin Yan   +13 more
wiley   +1 more source

Prairie Repertory Theatre costume making

open access: yes, 2017
Members of the Prairie Repertory Theatre company are sewing costumes for a ...
Prairie Repertory Theatre Company
core   +1 more source

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