Cellular Identity Crisis: RD3 Loss Fuels Plasticity and Immune Silence in Progressive Neuroblastoma
Researchers discovered that therapy‐induced loss of RD3 protein in neuroblastoma triggers a dangerous shift: cancer cells become more stem‐like, invasive, and resistant to treatment while evading immune detection. RD3 loss suppresses antigen presentation and boosts immune checkpoints, creating an immune‐silent environment.
Poorvi Subramanian +7 more
wiley +1 more source
John Antill's Symphony on a City (1959) and its place within the Australian symphonic repertory of the 1950s [PDF]
Rhoderick McNeill
openalex
Parents of Children with Congenital Heart Disease (CHD): A Narrative Study of the Social and Clinical Impact of CHD Diagnosis on Their Role and Health. [PDF]
Moro C, Iudici A, Turchi GP.
europepmc +1 more source
Traceless Regulation of Genetic Circuitry
Energy‐based, as opposed to molecular, control offers unprecedented improvements in key circuit parameters. This review summarizes the fundamentals of such traceless switches, categorizes them by trigger modalities, and compares and contrasts distinct advantages as well as shortcomings of each kind.
Gokberk Unal, Martin Fussenegger
wiley +1 more source
Filling the gaps: Original chronologies of silver fir (<i>Abies alba</i> Mill.) and European beech (<i>Fagus sylvatica</i> L.) living trees in the French Pyrenees. [PDF]
Saulnier M +10 more
europepmc +1 more source
Self-concept 6 months after traumatic brain injury and its relationship with emotional functioning. [PDF]
Mascialino G +5 more
europepmc +1 more source
Microbial synthesis of nanomaterials (NMs) is eco‐friendly, but the screening of microorganisms is limited by inefficient traditional methods (currently only involving∽400 microorganisms/90 NMs). We propose AI framework MicrobeDiscover, integrating a knowledge graph of microbe‐NM interactions.
Ludi Wang +12 more
wiley +1 more source
Why do urban travelers select multimodal travel options: A repertory grid analysis
T. Clauss, Sebastian Döppe
semanticscholar +1 more source
LLM-based robot personality simulation and cognitive system. [PDF]
Lo JH, Huang HP, Lo JS.
europepmc +1 more source
Regulatory T cells (Tregs) suppress antitumor immunity. This study identifies that the translation scaffold DAP5/eIF4G2 is upregulated in tumor‐infiltrating Tregs (ti‐Tregs). DAP5 mediates an alternate translation mode to sustain CD25 and MCL‐1 expression, which is critical for ti‐Treg stability and survival in the tumor microenvironment.
Xiaojiang Lai +12 more
wiley +1 more source

