Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer
PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta +10 more
wiley +1 more source
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
Perceived Exertion, Neuromuscular Activation, and Training Volume in Older Adults: Validating RPE-1 in Moderate-Velocity Elastic Band Resistance Training. [PDF]
Colado JC +5 more
europepmc +1 more source
Advertising Repetition: A Meta-Analysis on Effective Frequency in Advertising
S. Schmidt, M. Eisend
semanticscholar +1 more source
Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin
Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon +4 more
wiley +1 more source
A real time action scoring system for movement analysis and feedback in physical therapy using human pose estimation. [PDF]
Ullah R +5 more
europepmc +1 more source
Nichts ist erledigt, nur weil es verging: Repetition. Repetition. Repetition.
Nextex St.
openaire +1 more source
Sentence repetition: what does the task measure?
Kamila Polišenská, S. Chiat, P. Roy
semanticscholar +1 more source
To integrate multiple transcriptomics data with severe batch effects for identifying MB subtypes, we developed a novel and accurate computational method named RaMBat, which leveraged subtype‐specific gene expression ranking information instead of absolute gene expression levels to address batch effects of diverse data sources.
Mengtao Sun, Jieqiong Wang, Shibiao Wan
wiley +1 more source
Integrated transmission-reflection strong-field terahertz time-domain spectroscopy. [PDF]
Li J +10 more
europepmc +1 more source

