Results 131 to 140 of about 1,236,617 (269)

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

Molecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra, Shamsudheen Karuthedath Vellarikkal, Lixia Li, Hong Sun, Khoa Nguyen, Amber Montano, Suchitra Natarajan, Federica Piccioni, Alex Michael Tamburino, Xin Yu, Aleksandra Katarzyna Olow   +10 more
wiley   +1 more source

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

Molecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son, Lily L. Remsing Rix, Bin Fang, Eric A. Welsh, Nicole V. Bremer, Valentina Foglizzo, Paola Roa, Nickole Sigcha‐Coello, Yi Liao, Eric B. Haura, Alexander Drilon, John M. Koomen, Emiliano Cocco, Uwe Rix   +13 more
wiley   +1 more source

Multi-Regional Adaptation in Human Auditory Association Cortex

Frontiers in Human Neuroscience, 2017
In auditory cortex, neural responses decrease with stimulus repetition, known as adaptation. Adaptation is thought to facilitate detection of novel sounds and improve perception in noisy environments.
Urszula Malinowska, Nathan E. Crone, Frederick A. Lenz, Mackenzie Cervenka, Dana Boatman-Reich, Dana Boatman-Reich   +5 more
doaj   +1 more source

Molecular characterisation of human penile carcinoma and generation of paired epithelial primary cell lines

Molecular Oncology, EarlyView.
Generation of two normal and tumour (cancerous) paired human cell lines using an established tissue culture technique and their characterisation is described. Cell lines were characterised at cellular, protein, chromosome and gene expression levels and for HPV status.
Simon Broad, Mahmood Hachim, Tom Bertin, Karolina Penderecka, Rifat Hamoudi, Saif Khan, Rui Henrique, Natalie Bergmoser, Manit Arya, Kalle Sipila, Matteo Vietri Rudan, Asif Muneer, Aamir Ahmed   +12 more
wiley   +1 more source

fMRI adaptation between action observation and action execution reveals cortical areas with mirror neuron properties in human BA 44/45

Frontiers in Human Neuroscience, 2016
Mirror Neurons (MNs) are considered to be the supporting neural mechanism for action understanding. MNs have been identified in monkey’s area F5.
Stephan ede La Rosa, Frieder Leon Schillinger, Frieder Leon Schillinger, Frieder Leon Schillinger, Heinrich H. Bülthoff, Heinrich H. Bülthoff, Johannes eSchultz, Johannes eSchultz, Kamil eUludag, Kamil eUludag   +9 more
doaj   +1 more source

Realization of a cascaded quantum system: heralded absorption of a single photon qubit by a single-electron charged quantum dot

, 2017
Photonic losses pose a major limitation for implementation of quantum state transfer between nodes of a quantum network. A measurement that heralds successful transfer without revealing any information about the qubit may alleviate this limitation. Here,
Delteil, Aymeric, Fält, Stefan, Imamoğlu, Ataç, Sun, Zhe   +3 more
core   +1 more source

Cis‐regulatory and long noncoding RNA alterations in breast cancer – current insights, biomarker utility, and the critical need for functional validation

Molecular Oncology, EarlyView.
The noncoding region of the genome plays a key role in regulating gene expression, and mutations within these regions are capable of altering it. Researchers have identified multiple functional noncoding mutations associated with increased cancer risk in the genome of breast cancer patients.
Arnau Cuy Saqués, Aracele Martinez‐Mendez, John Crown, Alex Eustace   +3 more
wiley   +1 more source

14.5 GHz passive harmonic mode-locking in a dispersion compensated Tm-doped fiber laser

Scientific Reports, 2017
We demonstrate a high repetition rate passive harmonic mode-locking (HML) based on nonlinear polarization evolution (NPE) technique in a Tm-doped ring fiber laser cavity.
Yazhou Wang, Jianfeng Li, Kundong Mo, Yanyan Wang, Fei Liu, Yong Liu   +5 more
doaj   +1 more source

Event-related brain potential correlates of human auditory sensory memory-trace formation [PDF]

, 2005
The event-related potential (ERP) component mismatch negativity (MMN) is a neural marker of human echoic memory. MMN is elicited by deviant sounds embedded in a stream of frequent standards, reflecting the deviation from an inferred memory trace of the ...
Baldeweg, T, Dwivedi, P, Gruzelier, JH, Haenschel, C, Vernon, DJ   +4 more
core  

Effect of inter-train interval on the induction of repetition suppression of motor-evoked potentials using transcranial magnetic stimulation

PLoS ONE, 2017
Repetition suppression (RS) is evident as a weakened response to repeated stimuli after the initial response. RS has been demonstrated in motor-evoked potentials (MEPs) induced with transcranial magnetic stimulation (TMS).
M. Pitkänen, E. Kallioniemi, P. Julkunen   +2 more
semanticscholar   +1 more source