Results 21 to 30 of about 2,355 (177)

LC‐OCT Features in Vitiligo: A Preliminary Report

JEADV Clinical Practice, EarlyView.
ABSTRACT Background Vitiligo is a chronic depigmenting disorder characterized by the selective loss of melanocytes, leading to the progressive development of hypopigmented macules and patches. Line‐field confocal optical coherence tomography (LC‐OCT) is a novel imaging technique that combines the advantages of optical coherence tomography (OCT) and ...
Gerardo Palmisano, Daniele Omar Traini, Lorenzo Maria Pinto, Alessandra D'Amore, Mariano Suppa, Alessandro Di Stefani, Ketty Peris   +6 more
wiley   +1 more source

Microneedling and 5-Fluorouracil in Treating Stable Vitiligo in Hitherto Unstudied High Prevalence Population

Indian Journal of Dermatology
Background Vitiligo, affecting 0.25% in India (>1% in Jharkhand), stigmatises and devastates self-esteem/relationships causing depression. Apart from medical treatment, surgical procedures like applying 5-fluorouracil after microneedling are to be ...
B Abhirami, Prabhat Kumar, Dharmendra K. Mishra   +2 more
doaj   +1 more source

Non-cultured melanocyte transfer in the management of stable vitiligo

Journal of Family Medicine and Primary Care, 2019
Background and Aims: Present study aimed to determine the clinical outcome for non-cultured melanocyte transfer in the management of stable vitiligo. Methods: A hospital based prospective study was conducted including 50 stable unresponsive patients of ...
Birinder Singh Gill, Manmohan Singh Brar, Neha Chaudhary, Avneet Randhawa   +3 more
doaj   +1 more source

A Case of Lentigo Maligna Presenting as Repigmentation of Hair in a Scalp That Previously Underwent Radiotherapy for Tinea Capitis

Australasian Journal of Dermatology, EarlyView.
ABSTRACT Lentigo maligna has occasionally been noted to have the capacity to invade and repigment grey hairs. We present a case of a 78‐year‐old male who presented with a patch of brown hair on the vertex of the scalp in an area of previously white hair.
Madeleine Louise Kelly, Ken Low, Robert M. Miller   +2 more
wiley   +1 more source

Emerging Paediatric Uses of Dupilumab Beyond Approvals

Clinical &Experimental Allergy, EarlyView.
Dupilumab, through IL‐4Rα blockade, shows promising efficacy beyond approved indications in paediatric diseases driven by T2 inflammation. Emerging evidence—mainly from small studies—supports improvements in disease severity and quality of life, highlighting its potential as a targeted, steroid‐sparing therapy while underscoring the need for ...
Simone Foti Randazzese, Anna Calamita, Diletta D'Angelo, Alessia Marseglia, Esther Mesa Lombardero, Sara Pedersoli, Micol Tedeschi, Mara De Amici, Sara Manti, Valeria Brazzelli, Amelia Licari, Gian Luigi Marseglia   +11 more
wiley   +1 more source

Comparative Clinical Evaluation of Topical 5-Fluorouracil and Tacrolimus in Vitiligo Vulgaris: A Randomized Double-Blind Study [PDF]

Studies in Multidisciplinary Medical Research
Vitiligo is the most common acquired pigmentary disorder, significantly impacting patients' quality of life. Although various treatment modalities exist, none have proven universally effective. Topical 5-fluorouracil (5-FU) and tacrolimus have both shown
Fariba Shadfar, Fatemeh Raoufi
doaj   +1 more source

Out‐of‐pocket costs and time spent on disease management by vitiligo patients: a cross‐sectional questionnaire study in German‐speaking countries

JDDG: Journal der Deutschen Dermatologischen Gesellschaft, EarlyView.
Summary Background and objectives The financial and time‐related burden of patients with vitiligo remains insufficiently studied. This study aimed to quantify out‐of‐pocket costs (OOPC) and time expenditure for vitiligo management and the associated sociodemographic, clinical, and behavioral factors in German‐speaking countries.
Christine Gasteiger, Michael Hindelang, Stefanie Ziehfreund, Hannah Wecker, Tilo Biedermann, Alexander Zink   +5 more
wiley   +1 more source

PDE4 Inhibition in Dermatologic Disease: Impacts Beyond Inflammation

International Journal of Dermatology, EarlyView.
This graphical abstract demonstrates the comprehensive mechanism of PDE4 inhibition in skin physiology. By increasing intracellular cAMP and activating PKA, PDE4 inhibitors exert pleiotropic effects, including immune modulation, pigmentation regulation, barrier enhancement, sensory neuron modulation, and improved wound healing with reduced fibrosis ...
Keana Khodadad, Nicole E. Chin, Raj Chovatiya   +2 more
wiley   +1 more source

Understanding Exosomes in Hair Regeneration

Periodontology 2000, EarlyView.
Abstract Background Alopecia is a prevalent condition correlated with significant psychosocial challenges, while contemporary treatments exhibit variable efficacy, require extended use, and may cause adverse effects. This review aimed to comprehensively assess exosome‐mediated interventions as a novel cell‐free regenerative approach for hair ...
Paras Ahmad, Catherine Davies, Anton Sculean, Richard J. Miron   +3 more
wiley   +1 more source

Staurosporine Drives Non‐Canonical Melanocyte Maturation by Coupling β‐Catenin Signaling to Actin‐Dependent Dendrite Remodeling

Pigment Cell &Melanoma Research, Volume 39, Issue 5, September 2026.
Staurosporine drives non‐canonical melanocyte maturation through β‐catenin‐dependent actin remodeling. Functional maturation enhances dendrite architecture and melanogenic differentiation without inducing melanocyte proliferation, providing a biological framework for restoring functional melanocytes in acquired hypopigmentary disorders.
Kangning Xu, Lingli Yang, Sylvia Lai, Fei Yang, Yasutaka Kuroda, Daisuke Tsuruta, Ichiro Katayama   +6 more
wiley   +1 more source