Results 131 to 140 of about 3,310,318 (290)

Extended Trochanteric Osteotomy Increases the Risk of Tapered Splined Stem Subsidence in Revision Total Hip Arthroplasty

JBJS Open Access
Introduction:. In the United States, tapered splined titanium stems (TSTSs) are the most frequently used femoral stem design in revision total hip arthroplasty.
Josef E. Jolissaint, MD, Samuel Rodriguez, MD, Leonardo Albertini Sanchez, BA, Travis R. Weiner, BS, Elizabeth B. Gausden, MD, MPH, Jason L. Blevins, MD, Peter Sculco, MD, Jose Rodriguez, MD, FAOA   +7 more
doaj   +1 more source

Intein‐based modular chimeric antigen receptor platform for specific CD19/CD20 co‐targeting

Molecular Oncology, EarlyView.
CARtein is a modular CAR platform that uses split inteins to splice antigen‐recognition modules onto a universal signaling backbone, enabling precise, scarless assembly without re‐engineering signaling domains. Deployed here against CD19 and CD20 in B‐cell malignancies, the design supports flexible multi‐antigen targeting to boost T‐cell activation and
Pablo Gonzalez‐Garcia, Noelia Moares, Wenjie Yi‐He, Rosa Luna‐Espejo, Ricardo Fernandez‐Cisnal, Javier Ocaña‐Cuesta, Juan P. Muñoz‐Miranda, Antonio Gabucio, Cecilia M. Fernandez‐Ponce, Francisco Garcia‐Cozar   +9 more
wiley   +1 more source

Open Cow Replacement Decisions: an Application of Asset Replacement Theory [PDF]

Beef producers must decide what to do with a cow that fails to conceive during the breeding season. Keeping the open cow results in a years expenses without any revenue.
Anderson, John D., Ibendahl, Gregory A.
core   +1 more source

Comparative effectiveness of sotrovimab and molnupiravir for preventing severe COVID-19 outcomes in non-hospitalised patients on kidney replacement therapy: observational cohort study using the OpenSAFELY-UKRR linked platform and SRR database [PDF]

, 2022
Bang Zheng, Jacqueline Campbell, Edward J Carr, John Tazare, Linda Nab, Viyaasan Mahalingasivam, Amir Mehrkar, Shalini Santhakumaran, Retha Steenkamp, Fiona Loud, Susan Lyon, Miranda Scanlon, William Hulme, Amelia Green, Helen J Curtis, Louis Fisher, Edward P K Parker, Ben Goldacre, Ian Douglas, Stephen Evans, Brian MacKenna, Samira Bell, Laurie A. Tomlinson, Dorothea Nitsch   +23 more
openalex   +1 more source

Reducing edge loading and alignment outliers with image-free robotic-assisted unicompartmental knee arthroplasty: a case controlled study

Arthroplasty
Background Survivorship of medial unicompartmental knee arthroplasty (UKA) is technique-dependent. Correct femoral-tibial component positioning associates with improved survivorship.
Wai Hong Lau, Wai Kiu Thomas Liu, Kwong Yuen Chiu, Man Hong Cheung, Amy Cheung, Ping Keung Chan, Vincent Wai Kwan Chan, Henry Fu   +7 more
doaj   +1 more source

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

Molecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra, Shamsudheen Karuthedath Vellarikkal, Lixia Li, Hong Sun, Khoa Nguyen, Amber Montano, Suchitra Natarajan, Federica Piccioni, Alex Michael Tamburino, Xin Yu, Aleksandra Katarzyna Olow   +10 more
wiley   +1 more source

The Value and Risk of Defined Contribution Pension Schemes: International Evidence [PDF]

Using data on historical returns on international financial assets, the paper simulates pension fund and pension replacement ratios, building up frequency distributions of these ratios for individuals saving in a defined contribution pension plan in ...
Edmund Cannon, Ian Tonks
core  

Explant Analysis of Total Disc Replacement [PDF]

, 2006
Explant analysis of human disc prostheses allow early evaluation of the host response to the prosthesis and the response of the prosthesis from the host. Furthermore, early predictions of failure and wear can be obtained.
Anderson, Paul A., Kurtz, Steven M., Toth, Jeffrey M.   +2 more
core   +1 more source

Efficacy and Tolerability of an Individualized Dosing Regimen for Adult Growth Hormone Replacement Therapy in Comparison with Fixed Body Weight-Based Dosing [PDF]

, 2004
Andrew R. Hoffman, Christian J. Strasburger, Anthony J. Zagar, Werner Blum, Anne Kehely, Mark L. Hartman   +5 more
openalex   +1 more source

Effect of chemotherapy on passenger mutations in metastatic colorectal cancer

Molecular Oncology, EarlyView.
Changes in passenger mutation load and predicted immunotherapy response after chemotherapy treatment. Tumor cells rich with passenger mutations have increased sensitivity to chemotherapy. Correlation of passenger mutations with neoantigen load suggests highly mutated clones promote a more effective response to immunotherapy, and therefore, first‐line ...
Marium T. Siddiqui, Matthew A. Cottam, Muhammad Bilal Mirza, Keeli B. Lewis, Kristen K. Ciombor, Mary Kay Washington, Kamran Idrees   +6 more
wiley   +1 more source