Results 71 to 80 of about 1,484,991 (300)
Structural biology of ferritin nanocages
FEBS Letters, EarlyView.Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley +1 more source
Transcatheter aortic valve replacement
Research Reports in Clinical Cardiology, 2013 Anneke Damberg, Carina Benstoem, Ruediger Autschbach, Andreas GoetzenichDepartment of Cardiovascular and Thoracic Surgery, University Clinic RWTH Aachen, Aachen, GermanyAbstract: The standard treatment for symptomatic severe aortic valve stenosis is ...
Damberg A +3 more
doaj
Passenger accumulator fed railcars in regional railway traffic [PDF]
Transport Problems, 2015 This paper is focused on contemporary posibilities of replacement diesel-powered railcars by accumulator powered railcars in regional railway traffic. In the first part of the paper, there are described advantages and disadvantages of this replacement ...
Radovan DOLEČEK +3 more
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FEBS Letters, EarlyView.We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley +1 more source
Journal of Cardiovascular Magnetic Resonance, 2011 Surgical management of tetralogy of Fallot (TOF) results in anatomic and functional abnormalities in the majority of patients. Although right ventricular volume load due to severe pulmonary regurgitation can be tolerated for many years, there is now ...
Geva Tal
doaj +1 more source
FEBS Letters, EarlyView.Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes +4 more
wiley +1 more source
Advances in understanding cartilage remodeling [v1; ref status: indexed, http://f1000r.es/5e6]
F1000Research, 2015 Cartilage remodeling is currently among the most popular topics in osteoarthritis research. Remodeling includes removal of the existing cartilage and replacement by neo-cartilage.
Yefu Li, Lin Xu
doaj +1 more source
Computer Architecture with Associative Processor Replacing Last-Level Cache and SIMD Accelerator
IEEE Transactions on Computers, 2015 This study presents a novel computer architecture where a last level cache and a SIMD accelerator are replaced by an Associative Processor. Associative Processor combines data storage and data processing and provides parallel computational capabilities and data memory at the same time.
Yavits, Leonid +2 more
openaire +2 more sources
Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
A New Cache Replacement Policy for Improving Last Level Cache Performance
Journal of KIISE, 2014 캐쉬 교체 기법은 캐쉬 미스를 감소시키기 위해서 개발되었다. 마이크로프로세서와 주기억장치의 속도 차이를 해결하기 위해서는 캐쉬 교체 기법의 성능이 중요하다. 일반적인 캐쉬 교체 기법으로는 LRU 기법이 있으며 대부분의 마이크로프로세서에서 캐쉬 교체 기법으로 LRU 기법을 사용한다. 그러나, 최근의 연구에 따르면 LRU 기법과 최적 교체(OPT) 기법 간의 성능 차이는 매우 크다. LRU 기법의 성능은 많은 연구를 통해서 검증되었지만, 캐쉬 사상방식이 높아질수록 LRU 기법과 OPT 기법의 성능 차이는 증가한다. 본 논문에서는 기존의 LRU 기법을 활용하여 캐쉬 성능을 향상시키는 캐쉬 교체 기법을 제안하였다.
Cong Thuan Do +3 more
openaire +1 more source