Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
Immunoglobulin replacement therapy in secondary hypogammaglobulinemia
Frontiers in Immunology, 2014 Immunoglobulin (Ig) replacement therapy dramatically changed the clinical course of primary hypogammaglobulinemias, significantly reducing the incidence of infectious events.
Nicolò eCompagno +3 more
doaj +1 more source
The supply chain in air capability acquisition by the New Zealand Defence Force : a thesis presented in partial fulfilment of the requirements for the degree of Master of Arts in Defence and Security Studies at Massey University, Manawatū, New Zealand [PDF]
, 2018 Over the last decade the New Zealand Government has acquired and introduced into operational service, two important platforms for air power capability, namely the new NH90, and SH-2G(I) Seasprite helicopters.
Wemyss, Karen A.
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FEBS Letters, EarlyView.This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel +13 more
wiley +1 more source
Mouse models in Arrhythmogenic Right Ventricular Cardiomyopathy
Frontiers in Physiology, 2012 Arrhythmogenic right ventricular cardiomyopathy (ARVC) is a heart muscle disorder characterized by fibrofatty replacement of cardiomyocytes. The cardinal manifestations are arrhythmias, sudden cardiac death and seldom heart failure.
Elisabeth M Lodder, Stefania eRizzo
doaj +1 more source
Learning, Experimentation, and Long-Run Behavior in Games [PDF]
This paper investigates a class of population-learning dynamics. In every period agents either adopt a best reply to the current distribution of actual play, or a best reply to a sample, taken with replacement, from the distribution of intended play (the
Blume, A.
core +1 more source
Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells
Molecular Oncology, EarlyView.Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son +13 more
wiley +1 more source
Molecular Oncology, EarlyView.We developed and validated a DNA methylation–based biomarker panel to distinguish pleural mesothelioma from other pleural conditions. Using the IMPRESS technology, we translated this panel into a clinically applicable assay. The resulting two classifier models demonstrated excellent performance, achieving high AUC values and strong diagnostic accuracy.
Janah Vandenhoeck +12 more
wiley +1 more source
A library of Taylor models for PVS automatic proof checker [PDF]
, 2006 We present in this paper a library to compute with Taylor models, a technique extending interval arithmetic to reduce decorrelation and to solve differential equations. Numerical software usually produces only numerical results.
Cháves, Francisco, Daumas, Marc
core +8 more sources
Equivalent Mid-Term Results of Open vs Endoscopic Gluteal Tendon Tear Repair Using Suture Anchors in Forty-Five Patients. [PDF]
, 2020 BackgroundLittle is known about the relative efficacy of open (OGR) vs endoscopic (EGR) gluteal tendon repair of gluteal tendon tears in minimizing pain and restoring function.
Bini, Stefano A +5 more
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