Results 31 to 40 of about 567,454 (308)

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source

Sustainable bioplastics manufacturing from renewable sources

FEBS Open Bio, EarlyView.
Bioplastics are manufactured by using polymers from different bio‐based sources. These novel materials not only offer biodegradability but also possess various functional properties that make them suitable for diverse applications. Recent developments in the preparation of bioplastics are reported, highlighting the distinct properties of each type of ...
C. Valeria L. Giosafatto, Marika Avitabile, Michela Famiglietti, Talayeh Kordjazi, Marzieh Moosavi‐Nasab, Odile F. Restaino, Loredana Mariniello   +6 more
wiley   +1 more source

A Net Present Value Analysis of Opportunity-Based Age Replacement Models in Discrete Time

Mathematics
Two important opportunistic age replacement models, under replacement first and last disciplines, are generalized in discrete time. The net present value (NPV) is applied to formulate the expected total costs. The priority of multiple replacement options
Jing Wu, Cunhua Qian, Tadashi Dohi
doaj   +1 more source

Understanding bio‐based polymers: A study of origins, properties, biodegradation and their impact on health and the environment

FEBS Open Bio, EarlyView.
This review provides an overview of bio‐based polymer sources, their unique functional properties and their environmental impact, and addresses their role as sustainable alternatives. It discusses end‐of‐life options, including composting and anaerobic digestion for renewable energy.
Sabina Kolbl Repinc, Blaž Stres, Mirica Karlovits, Igor Karlovits, Petra Jerič, Ondrej Panák, Anja Verbič, Blaž Likozar, Uroš Novak   +8 more
wiley   +1 more source

Reinforcement Learning-Based Cache Replacement Policies for Multicore Processors

IEEE Access
High-performance computing (HPC) systems need to handle ever-increasing data sizes for fast processing and quick response times. However, modern processors’ caches are unable to handle massive amounts of data, leading to significant cache miss ...
Matheus A. Souza, Henrique C. Freitas
doaj   +1 more source

Adapting ACME to the database caching environment : a thesis presented in partial fulfilment of the requirements for the degree of Master of Science in Information Systems at Massey University [PDF]

, 2003
The field of database cache replacement has seen a great many replacement policies presented in the past few years. As the challenge to find the optimal replacement policy continues, new methods and techniques of determining cache victims have been ...
Riaz-ud-Din, Faizal
core  

Sequential Nonparametric Age Replacement Policies

The Annals of Statistics, 1985
Consider an age replacement policy, by which a stochastically failing unit is replaced at failure or after being in service for t units of time, whichever comes first. The problem is to estimate sequentially the optimal replacement time \(\phi^*\) which minimizes the expected long-run average cost.
Frees, Edward W., Ruppert, David
openaire   +2 more sources

Tracking Motor Progression and Device‐Aided Therapy Eligibility in Parkinson's Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To characterise the progression of motor symptoms and identify eligibility for device‐aided therapies in Parkinson's disease, using both the 5‐2‐1 criteria and a refined clinical definition, while examining differences across genetic subgroups.
David Ledingham, Sahana Sathyanarayana, Charlotte B. Stewart, Robyn Iredale, Victoria Foster, Debra Galley, Mark Baker, Nicola Pavese   +7 more
wiley   +1 more source

A Cache Model for Modern Processors [PDF]

, 2015
Modern processors use high-performance cache replacement policies that outperform traditional alternatives like least-recently used (LRU). Unfortunately, current cache models use stack distances to predict LRU or its variants, and cannot capture these ...
Beckmann, Nathan, Sanchez, Daniel
core  

Frailty Exacerbates Disability in Progressive Multiple Sclerosis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background To evaluate frailty in severe progressive multiple sclerosis (PMS) and to investigate the underlying mechanisms. Methods This prospective, cross‐sectional, multicenter study enrolled a late severe PMS group requiring skilled nursing (n = 53) and an age, sex, and disease duration‐matched control PMS group (n = 53).
Taylor R. Wicks, Anna Wolska, Diala Ghazal, Dejan Jakimovski, Bianca Weinstock‐Guttman, Alexander Burnham, Niels Bergsland, Michael G. Dwyer, Alan T. Remaley, Robert Zivadinov, Murali Ramanathan   +10 more
wiley   +1 more source