Results 101 to 110 of about 1,865,365 (306)

Employment Transitions in 13 European Countries. Levels, Distributions and Determining Factors of Net Replacement Rates [PDF]

open access: yes
This paper utilises a multi-country microsimulation tax-benefit model for Europe, EUROMOD, to simulate the distribution of net replacement rates for 13 European countries.
Cathal O’Donoghue, Herwig Immervoll
core  

Combining antibody conjugates with cytotoxic and immune‐stimulating payloads maximizes anti‐cancer activity

open access: yesMolecular Oncology, EarlyView.
Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang   +3 more
wiley   +1 more source

THE EFFECTS OF CHANGES IN THE TAX STRUCTURE ON AGRICULTURAL ASSET REPLACEMENT [PDF]

open access: yes
This paper uses a deterministic asset replacement model to examine the implications of the 1986 Tax Reform Act (TRA) for replacement investment in U.S. agriculture.
Smith, Vincent H.
core   +1 more source

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

open access: yesMolecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee   +8 more
wiley   +1 more source

How Changes in Financial Incentives Affect the Duration of Unemployment [PDF]

open access: yes
This paper studies how changes in the two key parameters of unemployment insurance - the benefit replacement rate (RR) and the potential duration of benefits (PBD) - affect the duration of unemployment.In 1989, the Austrian government made unemployment ...
Lalive, R.   +2 more
core   +4 more sources

Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer

open access: yesMolecular Oncology, EarlyView.
PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta   +10 more
wiley   +1 more source

Identification of serum protein biomarkers for pre‐cancerous lesions associated with pancreatic ductal adenocarcinoma

open access: yesMolecular Oncology, EarlyView.
This work identified serum proteins associated with pancreatic epithelial neoplasms (PanINs) and early‐stage PDAC. Proteomics screens assessed genetically engineered mice with abundant PanINs, KPC mice (Lox‐STOP‐Lox‐KrasG12D/+ Lox‐STOP‐Lox‐Trp53R172H/+ Pdx1‐Cre) before PDAC development and also early‐stage PDAC patients (n = 31), compared to benign ...
Hannah Mearns   +10 more
wiley   +1 more source

Social Policy Trends: Canada and U.S. Fertility Rates,1920-2018

open access: yesThe School of Public Policy Publications, 2019
The figure shows the fertility rate in Canada and the United States for each year from 1920 to 2018. The fertility rate measures the average number of children that would be born to each woman with prevailing age-specific fertility rates.
Ronald Kneebone
doaj  

In Vitro Digestion Properties of Low GI Wolfberry Multigrain Meal Replacement Powder

open access: yesShipin gongye ke-ji
The study aimed to determine the in vitro digestive properties of wolfberry multigrain meal replacement powders with a low glycemic index (GI). The basic components, water absorption and swelling rate, starch components, starch hydrolysis rate, and ...
Lingli TIAN   +4 more
doaj   +1 more source

What has happened to replacement rates?

open access: yes, 1996
Paper presented to the Irish Economics Association Annual Conference, Dromoland Castle, 12-14 April ...
Callan, Tim   +2 more
openaire   +2 more sources

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