Results 61 to 70 of about 361,305 (248)
FEBS Letters, EarlyView.Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson +7 more
wiley +1 more source
PROSODIC FEATURES OF ENGLISH HOMONYM HELLO
Вестник Северо-Кавказского федерального университета, 2022 This article is devoted to the study of prosodic features of Hello-containing phrases and their equivalents in different communicative contexts, it helps to improve knowledge of Anglo-Russian equivalents of homonymous structures.
Gayane Emilbarovna Markosyan
doaj
Tars: Timeliness-aware Adaptive Replica Selection for Key-Value Stores
, 2017 In current large-scale distributed key-value stores, a single end-user request may lead to key-value access across tens or hundreds of servers. The tail latency of these key-value accesses is crucial to the user experience and greatly impacts the revenue.
Fang, Liyuan +4 more
core +1 more source
FEBS Letters, EarlyView.We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee +3 more
wiley +1 more source
Critical behavior of disordered systems with replica symmetry breaking
, 2003 A field-theoretic description of the critical behavior of weakly disordered systems with a $p$-component order parameter is given. For systems of an arbitrary dimension in the range from three to four, a renormalization group analysis of the effective ...
A. Pelissetto +16 more
core +1 more source
FEBS Letters, EarlyView.We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley +1 more source
Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
Partition-function zeros of spherical spin glasses and their relevance to chaos
, 2012 We investigate partition-function zeros of the many-body interacting spherical spin glass, the so-called $p$-spin spherical model, with respect to the complex temperature in the thermodynamic limit.
Obuchi, Tomoyuki, Takahashi, Kazutaka
core +1 more source
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
Replica analysis of the generalized p-spin interaction glass model
, 2011 We investigate stability of replica symmetry breaking solutions in generalized $p$-spin models. It is shown that the kind of the transition to the one-step replica symmetry breaking state depends not only on the presence or absence of the reflection ...
Almeida J R L +15 more
core +1 more source