Results 101 to 110 of about 57,217 (289)
Loose Synchronization of Multithreaded Replicas
, 2002 Although multithreading can improve performance, it is a source of nondeterminism in application behavior. Existing approaches to replicating multithreaded applications either synchronize replicas at interrupt level, at the expense of performance, or use
Claudio Basile +3 more
core
Avoiding False Positive Conclusions in Molecular Simulation:The Importance of Replicas [PDF]
, 2018 Molecular simulations are a computational technique used to investigate the dynamics of proteins and other molecules. The free energy landscape of these simulations is often rugged, and minor differences in the initial velocities, floating-point ...
Bernhard Knapp +8 more
core +1 more source
Molecular Oncology, EarlyView.Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur +11 more
wiley +1 more source
Creating and evaluating replicas of surfaces machined by laser beam
MATEC Web of Conferences, 2017 In industrial practice, we often encounter a problem when it is necessary to measure and subsequently evaluate the surface quality of the part produced by the water jet, laser cutting.
Kubišová Milena +2 more
doaj +1 more source
Molecular Oncology, EarlyView.The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington +10 more
wiley +1 more source
IEEE AccessThe provision of Storage as a Service (STaaS) in many geo-distributed datacenters by several Cloud Storage Providers (CSPs) has made online cloud storage a great choice for replicating and distributing objects that are accessed worldwide.
Ali Y. Aldailamy +4 more
doaj +1 more source
Molecular Oncology, EarlyView.Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq +8 more
wiley +1 more source
Molecular Oncology, EarlyView.LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang +9 more
wiley +1 more source
Heritage Temples, Replicas, and Repetitions: Theorizing the Significance of Repeats as Resistance
, 2019 This paper discusses the potential of different Preah Vihear temple replicas to resist “discursive orders” that have been used to legitimate war in the border area between Thailand and Cambodia.
Lilja, Mona,, Baaz, Mikael,
core +1 more source
Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer
Molecular Oncology, EarlyView.Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas +16 more
wiley +1 more source