Results 191 to 200 of about 48,372 (292)
Physics-based nucleosome-resolution modeling of epigenetic-driven chromatin domain dynamics. [PDF]
Nucleic Acids ResGu C, Takada S, Brandani GB.
europepmc +1 more source
Correction to “Differential activity of MEK and ERK inhibitors in BRAF inhibitor resistant melanoma”
Molecular Oncology, EarlyView.
wiley +1 more source
Molecular characterization of covRS mutations in M1UK Streptococcus pyogenes
FEBS Open Bio, EarlyView.Group A Streptococcus (GAS) acquires covRS mutations driving a hypervirulent bacterial state, frequently associated with invasive disease‐like necrotizing fasciitis. We demonstrate that the newly emerged M1UK GAS lineage can also acquire these mutations.
Jarrad Pritchard +12 more
wiley +1 more source
U2 snRNP recognizes the branch site through a loaded-spring strand-invasion mechanism. [PDF]
Nucleic Acids ResPokorná P, Pena V, Magistrato A.
europepmc +1 more source
Transcripts enriched in codons that trigger P‐site tRNA‐mediated mRNA decay possess stable mRNA
FEBS Open Bio, EarlyView.PTMD codons were first described by Mendel et al. as mediators of an mRNA decay pathway dependent on the human protein CNOT3, homologous to yeast Not5. Our findings confirm that PTMD codons destabilize transcripts; however, unlike in yeast, the human pathway specifically targets and slightly destabilizes primarily stable mRNAs.
Rodolfo Lopes Carneiro +1 more
wiley +1 more source
Polymer Replicas of Fs-Laser-Induced Periodic Surface Structures for Cell Attachment. [PDF]
Materials (Basel)Ndjogo P +6 more
europepmc +1 more source
FEBS Open Bio, EarlyView.Hyperosmotic stress triggers the relocation of the CFIm complex from the nucleus to the cytoplasm. This shift creates a nuclear ‘stoichiometric bottleneck’, limiting CFIm availability for mRNA processing. Consequently, specific mRNAs like NUDT21 and DICER1 undergo targeted 3′UTR shortening, demonstrating how spatial protein dynamics drive rapid ...
Hitomi Soumiya +2 more
wiley +1 more source