Results 201 to 210 of about 508,345 (256)

S-phase checkpoint protects from aberrant replication fork processing and degradation. [PDF]

Nucleic Acids Res
Núñez-Martín I, Drury LS, Martínez-Jiménez MI, Blanco L, Diffley JFX, Aguilera A, Gómez-González B.   +6 more
europepmc   +1 more source

An Artificially Selected Cytokinin‐Pathway Transcription Factor Balances Soybean Yield and Pathogen Resistance

Advanced Science, EarlyView.
A cytokinin pathway transcription factor, RR2b, was artificially selected during soybean domestication and improvement based on its differential transcriptional activity, which correlates with ATT repeat polymorphisms in its promoter. RR2b balances yield and defense by fine‐tuning its expression level and offers a promising target for decoupling trade ...
Qun Ma, Yaqing Chen, Yiwen Gao, Xueting Hu, Qun Yang, Yucheng Liu, Peiyong Xin, Jijun Yan, Jinfang Chu, Lei Li, Zhixi Tian, Bo Ren   +11 more
wiley   +1 more source

Pathogenic variants in MAEA disrupt DNA replication fork stability and are associated with developmental abnormalities in humans. [PDF]

Sci Adv
Zeinali E, Mashayekhi F, Farraj RA, Hasanni T, Caron MC, Coulombe Y, Fitieh A, Glover JNM, Masson JY, Ismail IH.   +9 more
europepmc   +1 more source

Subversion of Atypical Mucin Traps by a Spore‐Coat Effector Blocks Cellular Immunity in Drosophila

Advanced Science, EarlyView.
While the entomopathogenic fungus Metarhizium robertsii can evade insect humoral immunity, its subversion of cellular defenses is still elusive. We identify Eac1 as a spore‐coat protein essential for infecting drosophilids by targeting atypical mucins (Sgf1 and Sgf2), which can entrap spores in a gel matrix and thereby facilitate hemocyte encapsulation.
Shiqin Li, Haimin Chen, Gangqi Fang, Dongxiang Wei, Hongyun Wu, Chen Chen, Song Hong, Chengshu Wang   +7 more
wiley   +1 more source

How DNA secondary structures drive replication fork instability.

DNA Repair (Amst)
Sethi A, Fernández-Casañas M, Delpino B, Coster G.   +3 more
europepmc   +1 more source

Loss of DNA replication fork protection by TIMELESS degradation supports oncogene-induced senescence. [PDF]

Biochem Biophys Res Commun
Park JJ, Rageul J, Lo N, Patel JA, Talos F, Kim H.   +5 more
europepmc   +1 more source

SIZ1‐Mediated SUMOylation of LBD29 Recruits ARF7 to Fine‐Tune Auxin Signaling in Lateral Root Development

Advanced Science, EarlyView.
Our findings establish SUMOylation as a key post‐translational control layer in auxin signaling. We show that SIZ1‐mediated SUMOylation of LBD29 promotes its association with ARF7, stabilizing a transcriptional hub that governs lateral root development.
Jiaxuan Sui, Qianlan Yin, Yiying Chen, Liping Zhang, Xiuyuan Yu, Qianqian Yu, Zhaojun Ding, Xiangpei Kong   +7 more
wiley   +1 more source

ATRX cooperates with TOP2B for replication fork stability and DNA damage response through G-quadruplex regulation. [PDF]

Nucleic Acids Res
Pang Y, Cheng M, Wang J, Wang R, Chen X, Zhang C, Yang Y, Ji T, Liu M, Zhang J, Zhong C.   +10 more
europepmc   +1 more source

QRICH1 Disrupts Endoplasmic Reticulum Homeostasis and Amplifies NF‐κB Signaling in Periodontal Ligament Stem Cells to Exacerbate Diabetic Periodontitis

Advanced Science, EarlyView.
QRICH1 has been established as a key factor contributing to impaired osteogenic potential and accelerated apoptosis of PDLSCs in diabetic periodontitis. QRICH1 not only significantly enhances UPR‐associated apoptotic signaling but also amplifies NF‐κB‐mediated inflammatory responses. Its inhibition restores osteogenic capacity and reduces alveolar bone
Han Li, Xiaoyu Yang, He Wang, Yunchun Kuang, Yiyao Hu, Houxuan Li, Shuhong Li, Deping Zeng, Jie Li, Jinlin Song   +9 more
wiley   +1 more source

Disparate requirements for RAD54L in replication fork reversal. [PDF]

Nucleic Acids Res
Uhrig ME, Sharma N, Maxwell P, Gomez J, Selemenakis P, Mazin AV, Wiese C.   +6 more
europepmc   +1 more source