Results 111 to 120 of about 3,588,418 (239)
Prereplicative complexes assembled in vitro support origin-dependent and independent DNA replication
EMBO Journal, 2014 Eukaryotic DNA replication initiates from multiple replication origins. To ensure each origin fires just once per cell cycle, initiation is divided into two biochemically discrete steps: the Mcm2‐7 helicase is first loaded into prereplicative complexes ...
K. On +5 more
semanticscholar +1 more source
Thymine starvation causes abortive initiation of chromosome replication critical for cell death in Escherichia coli [PDF]
, 2013 Presentado en: XXXVI Congreso SEBBM (Sociedad Española de Bioquímica y Biología Molecular), Madrid, 4-6 septiembre, 2013Thymineless death (TLD), a phenomenon in which thymine auxotrophy becomes lethal when cells are starved for thymine, can be prevented
Guzmán Cabañas, Elena +2 more
core
The Journal of Cell Biology, 2003 ![][1] Replication origins in vitro (red) and in vivo (green). After mitosis, cells prepare for the next round of DNA replication by assembling complexes of proteins on chromatin that will carry out the task of copying the genome.
openaire +2 more sources
Separating the effects of mutation and selection in producing DNA skew in bacterial chromosomes
BMC Genomics, 2007 Background Many bacterial chromosomes display nucleotide asymmetry, or skew, between the leading and lagging strands of replication. Mutational differences between these strands result in an overall pattern of skew that is centered about the origin of ...
Morton Brian R, Morton Richard A
doaj +1 more source
Strikingly higher frequency in centenarians and twins of mtDNA mutation causing remodeling of replication origin in leukocytes [PDF]
, 2003 The presence of a genetic component in longevity is well known. Here, the association of a mtDNA mutation with a prolonged life span in humans was investigated.
Asin-Cayuela, Jordi +9 more
core
OriDB, the DNA replication origin database updated and extended
Nucleic Acids Res., 2011 OriDB (http://www.oridb.org/) is a database containing collated genome-wide mapping studies of confirmed and predicted replication origin sites. The original database collated and curated Saccharomyces cerevisiae origin mapping studies.
C. C. Siow +3 more
semanticscholar +1 more source
BAHCC1 binds H4K20me1 to facilitate the MCM complex loading and DNA replication
Nature CommunicationsMono-methylation of histone H4 lysine 20 (H4K20me1) regulates DNA replication, cell cycle progression and DNA damage repair. How exactly H4K20me1 regulates these biological processes remains unclear.
Dongxu Li +16 more
doaj +1 more source
PLoS Genetics, 2017 In response to DNA damage during S phase, cells slow DNA replication. This slowing is orchestrated by the intra-S checkpoint and involves inhibition of origin firing and reduction of replication fork speed.
Divya Ramalingam Iyer, Nicholas Rhind
doaj +1 more source
φX 174 replicative form DNA replication, origin and direction
Journal of Molecular Biology, 1972 Heteroduplex replicative form of bacteriophage φX174 was prepared by annealing minus strand isolated from wild-type φX RF† with plus strand DNA, obtained from temperature-sensitive and amber mutants of φX in different cistrons. Three different kinds of bursts were produced by spheroplasts infected with heteroduplex RF: bursts with only wild-type phage,
Baas, P.D., Jansz, H.S.
openaire +3 more sources
In Vivo DNA Re-replication Elicits Lethal Tissue Dysplasias
Cell Reports, 2017 Summary: Mammalian DNA replication origins are “licensed” by the loading of DNA helicases, a reaction that is mediated by CDC6 and CDT1 proteins. After initiation of DNA synthesis, CDC6 and CDT1 are inhibited to prevent origin reactivation and DNA ...
Sergio Muñoz +6 more
doaj +1 more source