Results 41 to 50 of about 1,003,936 (218)

Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics

FEBS Letters, EarlyView.
Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt, Ana‐Maria Sandru, Georg Vucak, Sebastian Didusch, Biljana Riemelmoser, Karin Ehrenreiter, Markus Hartl, Lukas A. Huber, Manuela Baccarini   +8 more
wiley   +1 more source

Not Evidence for Baumol’s Cost Disease. A replication study of Hartwig (Journal of Health Economics, 2008)

International Journal for Re-Views in Empirical Economics, 2020
In his 2008 Journal of Health Economics paper, Jochen Hartwig claimed that Baumol’s Cost Disease (BCD) theory could explain observed increases in health care expenditures in OECD countries.
Akinwande Atanda, W. Robert Reed
doaj   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Rate and success of study replication in ecology and evolution [PDF]

PeerJ, 2019
The recent replication crisis has caused several scientific disciplines to self-reflect on the frequency with which they replicate previously published studies and to assess their success in such endeavours.
Clint D. Kelly
doaj   +2 more sources

Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network

FEBS Letters, EarlyView.
Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley   +1 more source

Replicating a study about children’s drawings concerning radiation

Multidisciplinary Journal for Education, Social and Technological Sciences, 2019
Radiation surrounds us in various forms and plays a huge role in our everyday life. However, little is known about student and children’s conceptions of this topic.
T. Plotz, F. Hollenthoner
doaj   +1 more source

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source

Synergistic perspectives—How single‐molecule biophysics complement biochemical understanding

FEBS Letters, EarlyView.
In this review, we discuss how ensemble biochemistry and single‐molecule approaches are complementary, outline commonly used single‐molecule techniques, and illustrate their relevance through two representative case studies: chromatin organization by SMC complexes and pathway choice during DNA double‐strand break repair.
Sara De Bragança, Eline L. Jansen, Jorine M. Eeftens   +2 more
wiley   +1 more source

Attitudinal, Normative, and Resource Factors Affecting Communication Scholars’ Data Sharing: A Replication Study

Media and Communication
This study explores the factors affecting communication scholars’ data-sharing intentions, a critical component of reproducibility and replicability in open science. We replicate Harper and Kim’s (2018) study, which employs the theory of planned behavior
Jinghong Xu, Rukun Zhang
doaj   +1 more source

No association for Chinese HBV-related hepatocellular carcinoma susceptibility SNP in other East Asian populations

BMC Medical Genetics, 2012
Background A recent genome-wide association study (GWAS) using chronic HBV (hepatitis B virus) carriers with and without hepatocellular carcinoma (HCC) in five independent Chinese populations found that one SNP (rs17401966) in KIF1B was associated with ...
Sawai Hiromi, Nishida Nao, Mbarek Hamdi, Matsuda Koichi, Mawatari Yoriko, Yamaoka Megumi, Hige Shuhei, Kang Jong-Hon, Abe Koichi, Mochida Satoshi, Watanabe Masaaki, Kurosaki Masayuki, Asahina Yasuhiro, Izumi Namiki, Honda Masao, Kaneko Shuichi, Tanaka Eiji, Matsuura Kentaro, Itoh Yoshito, Mita Eiji, Korenaga Masaaki, Hino Keisuke, Murawaki Yoshikazu, Hiasa Yoichi, Ide Tatsuya, Ito Kiyoaki, Sugiyama Masaya, Ahn Sang, Han Kwang-Hyub, Park Jun, Yuen Man-Fung, Nakamura Yusuke, Tanaka Yasuhito, Mizokami Masashi, Tokunaga Katsushi   +34 more
doaj   +1 more source