Results 111 to 120 of about 1,723 (252)

Molecular characterization of covRS mutations in M1UK Streptococcus pyogenes

FEBS Open Bio, EarlyView.
Group A Streptococcus (GAS) acquires covRS mutations driving a hypervirulent bacterial state, frequently associated with invasive disease‐like necrotizing fasciitis. We demonstrate that the newly emerged M1UK GAS lineage can also acquire these mutations.
Jarrad Pritchard, Emma‐Jayne Proctor, Jiawa Wang, Nikolas P. Johnston, Andrew Hayes, Georgia McCorkell, Haibo Yu, Jai Tree, Mark R. Davies, Mark J. Walker, Ronald Sluyter, Stephan Brouwer, Martina L. Sanderson‐Smith   +12 more
wiley   +1 more source

How to explore replicator equations?

, 2008
Replicator equations (RE) are among the basic tools in mathematical theory of selection and evolution. We develop a method for reducing a wide class of the RE, which in general are systems of differential equations in Banach space to escort systems of ODEs that in many cases can be explored analytically.
openaire   +2 more sources

Transcripts enriched in codons that trigger P‐site tRNA‐mediated mRNA decay possess stable mRNA

FEBS Open Bio, EarlyView.
PTMD codons were first described by Mendel et al. as mediators of an mRNA decay pathway dependent on the human protein CNOT3, homologous to yeast Not5. Our findings confirm that PTMD codons destabilize transcripts; however, unlike in yeast, the human pathway specifically targets and slightly destabilizes primarily stable mRNAs.
Rodolfo Lopes Carneiro, Fernando Lucas Palhano   +1 more
wiley   +1 more source

On the asymptotic behavior of the solutions to the replicator equation

, 2009
Selection systems and the corresponding replicator equations model the evolution of replicators with a high level of abstraction. In this paper we apply novel methods of analysis of selection systems to the replicator equations. To be suitable for the suggested algorithm the interaction matrix of the replicator equation should be transformed; in ...
Karev, Georgy P, Novozhilov, Artem S, Berezovskaya, Faina S   +2 more
openaire   +2 more sources

Hyperosmotic stress‐induced redistribution of pre‐mRNA cleavage factor I subunits is associated with shifts in alternative polyadenylation

FEBS Open Bio, EarlyView.
Hyperosmotic stress triggers the relocation of the CFIm complex from the nucleus to the cytoplasm. This shift creates a nuclear ‘stoichiometric bottleneck’, limiting CFIm availability for mRNA processing. Consequently, specific mRNAs like NUDT21 and DICER1 undergo targeted 3′UTR shortening, demonstrating how spatial protein dynamics drive rapid ...
Hitomi Soumiya, Masatake Osawa, Hidefumi Fukumitsu   +2 more
wiley   +1 more source

The Maximum Principle for Replicator Equations

, 1985
By introducing a non-Euclidean metric on the unit simplex, it is possible to identify an interesting class of gradient systems within the ubiquitous "replicator equations" of evolutionary biomathematics. In the case of homogeneous potentials, this leads to maximum principles governing the increase of the average fitness, both in population genetics and
openaire   +2 more sources

Yeast Gcn2 retains activity following humanization of its auto‐phosphorylation region

FEBS Open Bio, EarlyView.
Using Saccharomyces cerevisiae as a model to study Gcn2 activation and regulation is limited by the lack of antibodies detecting phosphorylated Gcn2. To overcome this, we engineered Gcn2‐HsC, a yeast Gcn2 variant recognizable by commercial anti‐human phospho‐GCN2 antibodies.
Reuben A. Anderson, Anja H. Schiemann, Evelyn Sattlegger   +2 more
wiley   +1 more source

Importin 7 mediates the nuclear import of HIV‐1 integrase via a specific interacting interface

FEBS Open Bio, EarlyView.
HIV‐1 integrase enables viral DNA integration into the host genome. By binding to the core domain of the host protein Importin 7 via its C‐terminal domain, the integrase is transported across the nuclear membrane into the nucleus, where integration of the viral genome into host DNA takes place. This translocation is a critical step for subsequent viral
Juana Bana, Avigail Yariv, Tal Oppenheim, Hadar Amartely, Dana Reichmann, Oded Livnah   +5 more
wiley   +1 more source

An evolutionary planning method for distribution networks considering prosumers and shared energy storage

Frontiers in Energy Research
This research provides a rolling planning method for distribution networks, which takes into account shared energy storage capacity configuration and grid topology optimization due to the stochastic unpredictability of the planning scenarios and the ...
Jinglin Han, Xichun Feng, Zhiyong Chen, Ping Hu, Hui Zhao, Yubing Chen, Nian Liu   +6 more
doaj   +1 more source

Imitation dynamics and the replicator equation

Europhysics Letters
Abstract Evolutionary game theory has impacted many fields of research by providing a mathematical framework for studying the evolution and maintenance of social and moral behaviors. This success is owed in large part to the demonstration that the central equation of this theory —the replicator equation— is the deterministic limit of a ...
openaire   +2 more sources