Results 91 to 100 of about 100,632 (325)

Unraveling the Morphological and Functional Maturation Mechanisms Underlying Human Neural Development Using iPSCs‐Derived Neuronal Model

Advanced Science, EarlyView.
Using human induced pluripotent stem cells (hiPSCs)‐derived neuronal model, Tian and colleagues reveal that voltage‐gated calcium channels Cav1.2 and Cav1.3, and their mediated calcium ion influx, are essential for early morphogenesis of human neuronal development, while ECEL1 underlies human neuronal functional developmental maturation through CALM3 ...
Yue Tian, Yi‐Chun Ou, Zi‐Xian Zhang, Jie Cai, Si‐Qing Cai, Guo‐Gang Xing   +5 more
wiley   +1 more source

Increase in neuroexcitability of unmyelinated C-type vagal ganglion neurons during initial postnatal development of visceral afferent reflex functions [PDF]

, 2013
BACKGROUND: Baroreflex gain increase up closely to adult level during initial postnatal weeks, and any interruption within this period will increase the risk of cardiovascular problems in later of life span. We hypothesize that this short period after
Cao, Pan‐Xiang, Han, Li‐Min, Li, Bai‐Yan, Li, Jun‐Nan, Liu, Dong‐Jie, Liu, Yang, Lu, Xiao‐Long, Pan, Xiao‐Dong, Qian, Zhao, Qiao, Guo‐Fen, Wang, Hao‐Yan, Wang, Li‐Juan, Xu, Bing, Yuan, Mei   +13 more
core   +2 more sources

ITGB1 Regulates Triple‐Negative Breast Cancer Development by Modulating the Tumor Microenvironment

Advanced Science, EarlyView.
ABSTRACT Tumorigenesis and metastasis are frequently attributed to the intricate interplay between cancer cells and the tumor microenvironment (TME). Comprehending the mechanisms and key regulators of cancer‐immune crosstalk in the TME is imperative for developing efficacious immunotherapy.
Nuozi Song, Siqi Chen, Lei Wang, Jessica Dang, Xu Cao, Stephanie Singh, Lu Yang, Jinhui Wang, Steven T. Rosen, Yingyu Wang, Chun‐Wei D. Chen, Cheng Zhang, Mingye Feng   +12 more
wiley   +1 more source

Macrophage‐derived Extracellular Vesicles Disguised AIEgen/IDO1 Inhibitor Nanoplatform Reactivate “Immune‐Hot” for Photothermal Immunotherapy via Multi‐Dimensionally Reprograms Tumor Microenvironment

Aggregate
Reversing the tumor microenvironment (TME) from “cold” to “hot” tumor represents a pivotal strategy to overcome the clinical bottleneck of poor response rates to immunotherapy in solid tumors.
Xue Li, Xianglong Zhao, Yin Zhou, Yu Liu, Yushuo Feng, Yeneng Dai, Ping Gong, Qi Zhao, Ming Dong   +8 more
doaj   +1 more source

Treatment of Electrical Storm with Amiodarone in Brugada Syndrome- an Unexpected Protective Effect [PDF]

, 2013
We are reporting on a 53 year old man with proven Brugada syndrome and ICD implantation for resuscitation in context of polymorphic VT. After recurrent arrhythmia he was treated with Amiodarone.
Lambiase, PD, Novak, J
core   +1 more source

Reprogramming the Myocardial Infarction Conductive Microenvironment with Superconductive Ionic Patch for Cardiac Function Repair

Advanced Science, EarlyView.
A super‐conductive ionic patch reprograms the post‐infarction microenvironment by enabling stable ionic migration and electrical signal transmission within damaged myocardium. The patch rapidly adheres to cardiac tissue, enhances conduction velocity, suppresses excitation‐contraction decoupling, and promotes structural and functional cardiac repair in ...
Changyong Wang, Zhuang Zhang, Qi Yin, Changgeng Xu, Linlin Liang, Siwei Li, Yuwei Zhao, Chunlan Wang, Jin Zhou   +8 more
wiley   +1 more source

Electrocardiographic Strain Pattern Is Associated With Left Ventricular Concentric Remodeling, Scar, and Mortality Over 10 Years: The Multi‐Ethnic Study of Atherosclerosis

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2017
BackgroundBoth ECG strain pattern and QRS measured left ventricular (LV) hypertrophy criteria are associated with LV hypertrophy and have been used for risk stratification.
Yuko Y. Inoue, Elsayed Z. Soliman, Kihei Yoneyama, Bharath Ambale‐Venkatesh, Colin O. Wu, Rodney Sparapani, David A. Bluemke, João A.C. Lima, Hiroshi Ashikaga   +8 more
doaj   +1 more source

Genetic association study of QT interval highlights role for calcium signaling pathways in myocardial repolarization

Nature Genetics, 2014
The QT interval, an electrocardiographic measure reflecting myocardial repolarization, is a heritable trait. QT prolongation is a risk factor for ventricular arrhythmias and sudden cardiac death (SCD) and could indicate the presence of the potentially ...
D. Arking, Sara L. Pulit, L. Crotti, P. van der Harst, P. Munroe, T. Koopmann, N. Sotoodehnia, Elizabeth J. Rossin, Michael P. Morley, Xinchen Wang, Andrew Johnson, Alicia Lundby, D. Gudbjartsson, Peter A. Noseworthy, M. Eijgelsheim, Yuki Bradford, Kirill V Tarasov, M. Dörr, M. Müller-Nurasyid, Annukka M. Lahtinen, I. Nolte, Albert V. Smith, J. Bis, A. Isaacs, Stephen J. Newhouse, Daniel S. Evans, Wendy S. Post, D. Waggott, L. Lyytikäinen, Andrew A. Hicks, L. Eisele, D. Ellinghaus, Caroline Hayward, P. Navarro, Sheila Ulivi, Toshiko Tanaka, D. Tester, S. Chatel, S. Gustafsson, M. Kumari, RichardW. Morris, Å. T. Naluai, S. Padmanabhan, A. Kluttig, Bernhard Strohmer, A. Panayiotou, Maria Torres, M. Knoflach, J. A. Hubacek, Kamil Slowikowski, Soumya Raychaudhuri, Runjun D. Kumar, Tamara B. Harris, L. Launer, A. Shuldiner, Alvaro Alonso, J. Bader, George B. Ehret, Hailiang Huang, W. Kao, James B. Strait, Peter W. Macfarlane, Morris J. Brown, M. Caulfield, Nilesh J. Samani, Florian Kronenberg, Johann Willeit, J. G. Smith, K. Greiser, H. M. Z. zu Schwabedissen, K. Werdan, Massimo Carella, Leopoldo Zelante, S. Heckbert, B. Psaty, J. Rotter, I. Kolčić, O. Polašek, Alan F. Wright, Maura B Griffin, Mark J Daly, D. Arnar, H. Hólm, U. Thorsteinsdóttir, Joshua C. Denny, Dan M. Roden, R. Zuvich, V. Emilsson, Andrew S. Plump, Martin G. Larson, Christopher J O'Donnell, Xiaoyan Yin, M. Bobbo, A. d’Adamo, A. Iorio, G. Sinagra, Ángel Carracedo, Steven R Cummings, Michael A. Nalls, Antti Jula, K. Kontula, A. Marjamaa, L. Oikarinen, M. Perola, K. Porthan, R. Erbel, Per Hoffmann, K. Jöckel, H. Kälsch, M. Nöthen, Hrgen consortium, M. den Hoed, Ruth J. F. Loos, Dag S. Thelle, C. Gieger, T. Meitinger, S. Perz, A. Peters, H. Prucha, Moritz F. Sinner, M. Waldenberger, Rudolf A. de Boer, L. Franke, P. A. van der Vleuten, Britt Maria Beckmann, Eimo Martens, A. Bardai, N. Hofman, A. Wilde, E R Behr, C. Dalageorgou, J. Giudicessi, A. Medeiros-Domingo, J. Barc, Florence Kyndt, Vincent Probst, A. Ghidoni, R. Insolia, Robert M Hamilton, Stephen W. Scherer, Jeffrey Brandimarto, Kenneth B. Margulies, Christine E. Moravec, Greco M. Fabiola Del, C. Fuchsberger, Jeffrey R. O'Connell, Wai K. Lee, Graham C.M. Watt, Harry Campbell, Sarah H Wild, N. E. El Mokhtari, Norbert Frey, F. Asselbergs, I. M. Leach, G. Navis, Maarten P van den Berg, D. van Veldhuisen, M. Kellis, B. Krijthe, Oscar H. Franco, A. Hofman, J. A. Kors, A. Uitterlinden, J. Witteman, Lyudmyla Kedenko, C. Lamina, B. Oostra, G. Abecasis, Edward G. Lakatta, A. Mulas, M. Orrù, D. Schlessinger, M. Uda, M. Markus, U. Völker, H. Snieder, Timothy D. Spector, J. Ärnlöv, Lars Lind, Johan Sundström, A. Syvänen, M. Kivimaki, M. Kähönen, N. Mononen, Olli T Raitakari, J. Viikari, Věra Adámková, Stefan Kiechl, M. Brion, Andrew N Nicolaides, B. Paulweber, Johannes Haerting, A. Dominiczak, Fredrik Nyberg, P. Whincup, A. Hingorani, Jean-Jacques Schott, C. Bezzina, E. Ingelsson, L. Ferrucci, Paolo Gasparini, James F. Wilson, I. Rudan, A. Franke, Thomas W. Mühleisen, P. Pramstaller, T. Lehtimäki, Andrew D. Paterson, A. Parsa, Yongmei Liu, C. V. van Duijn, D. Siscovick, V. Gudnason, Y. Jamshidi, V. Salomaa, S. Felix, S. Sanna, Marylyn D. Ritchie, Bruno H. Ch. Stricker, K. Stefansson, Laurie A. Boyer, Thomas P. Cappola, Jesper V. Olsen, K. Lage, Peter J. Schwartz, S. Kääb, Aravinda Chakravarti, Michael J. Ackerman, A. Pfeufer, P. D. de Bakker, C. Newton‐Cheh   +230 more
semanticscholar   +1 more source

Asymptotic properties of mathematical models of excitability [PDF]

, 2005
We analyse small parameters in selected models of biological excitability, including Hodgkin-Huxley (1952) model of nerve axon, Noble (1962) model of heart Purkinje fibres, and Courtemanche et al. (1998) model of human atrial cells.
Biktashev, V. N., Biktasheva, I. V., Simitev, R. D., Suckley, R.   +3 more
core   +2 more sources

Modulation of Transmural Repolarization [PDF]

Annals of the New York Academy of Sciences, 2005
Abstract: Ventricular myocardium in larger mammals has been shown to be comprised of three distinct cell types: epicardial, M, and endocardial. Epicardial and M cell action potentials differ from endocardial cells with respect to the morphology of phase 1.
openaire   +2 more sources