Results 91 to 100 of about 57,164 (287)

Human Foetal Neuroblasts Exhibit BK Channel‐Dependent Membrane Voltage Oscillations upon Depolarization

Advanced Science, EarlyView.
Primary cultures of neuroblasts isolated from the nucleus basalis of Meynert of 12‐weeks‐old human foetuses were prepared. Whole‐cell patch‐clamp recordings were performed by injecting a depolarizing stimulus current (+500 pA; 500 ms), and the membrane voltage recorded; this stimulus current evoked periodic‐like oscillations in membrane voltage ...
Elisabetta Coppi, Federica Cherchi, Martina Venturini, Federico Tommasi, Sandro Gonzi, Chiara Capacci, Giulia Guarnieri, Pasquale Gallina, Annamaria Morelli, Anna Maria Pugliese   +9 more
wiley   +1 more source

The effect of repolarization duration on the indices of the pump function of the heart ventricles in animals with different types of activation of the myocardium under ectopic excitation of ventricles

Russian Open Medical Journal, 2018
Background — The aim of the work was to study the influence of myocardial repolarization on the indices of the pump function in animals with different types of the myocardial activation (dog, amphibians) under ectopic excitation of the ventricles ...
Natalya A. Kibler, Vladimir P. Nyzhny, Dmitry N. Shmakov   +2 more
doaj   +1 more source

Reconstituted High-Density Lipoprotein Shortens Cardiac Repolarization [PDF]

, 2011
ObjectivesWe hypothesize that increasing high-density lipoprotein cholesterol (HDL-C) shortens cardiac repolarization.BackgroundHDL-C is inversely associated with sudden death.
Arie O. Verkerk, Sungnoon, Rattapong, Vaessen, Stefan F., Holleboom, Adriaan G., Tobias Opthof, Hester M. Den Ruijter, Remco Franssen, Franssen, Remco, Adriaan G. Holleboom, Stefan F. Vaessen, Erik S. Stroes, Opthof, Tobias, Diederik F. van Wijk, Johannes H. Levels, van Wijk, Diederik F., Kuivenhoven, Jan Albert, Levels, Johannes H., Ruben Coronel, Den Ruijter, Hester M., Rattapong Sungnoon, Verkerk, Arie O., Coronel, Ruben, Jan Albert Kuivenhoven, Stroes, Erik S.   +23 more
core   +1 more source

Nanovesicles With Mechanically Induced Adjuvanticity for Robust Melanoma Vaccination Toward Tumor‐Associated Macrophages

Advanced Science, EarlyView.
Rigidity‐tunable nanovesicle (P‐Pm) with mechanically induced adjuvanticity toward tumor‐associated macrophages (TAMs) was designed to engineer R848/gp100 antigen ‐loaded nanovaccine (P@Rg‐Pm), which achieved outstanding anti‐tumor outcomes in both therapeutic and preventive model of B16‐F10 melanoma.
Bangyue Luo, Liyan Qiu
wiley   +1 more source

Targeting the KCNC3‐Dependent Anterior Insular‐Lateral Orbitofrontal Cortex Glutamatergic Circuit Attenuates Post‐Traumatic Anxiety

Advanced Science, EarlyView.
Frontal lobe traumatic brain injury is associated with hyperactivity of an insular–orbitofrontal circuit in both patients and mice. By combination of integrating functional imaging, cell‐type–specific circuit manipulation, single‐cell transcriptomics, and whole‐cell recordings, this work identifies the downregulation of the potassium channel KCNC3 in ...
Meng‐Ge Li, Xiao‐Bo Qian, Hai‐Long Zhang, Di Li, Ling Ji, Xin‐Chun Xu, Jia‐Sheng Ding, Li‐Jun Yin, Li Zhang, Guang‐Yin Xu, Rong Gao   +10 more
wiley   +1 more source

Cardiac Repolarization in Health and Disease

, 2023
Abnormal cardiac repolarization is at the basis of life-threatening arrhythmias in various congenital and acquired cardiac diseases. Dysfunction of ion channels involved in repolarization at the cellular level are often the underlying cause of the ...
Amin, Ahmad S, Offerhaus, Joost A, Boukens, Bastiaan J, Amin, Ahmad S., Offerhaus, Joost A., Boukens, Bastiaan J., Krijger Juárez, Christian, Bezzina, Connie R., Krijger, Christian, Bezzina, Connie R   +9 more
core   +1 more source

An Aggregation‐Induced Polymerization Poly(Disulfide)‐Drug Nanoplatform for Autoimmune Uveitis Therapy via Inhibiting the cGAS‐STING Pathway

Advanced Science, EarlyView.
A cationic poly(disulfide)‐drug nanoplatform (LA/DexP) was developed to treat experimental autoimmune uveitis (EAU). With potent blood‐retinal barrier penetrability, LA/DexP releases DSP in response to high ROS and scavenges cfDNA to inhibit the cGAS‐STING signaling pathway.
Yuelan Wu, Wenbo Geng, Qinjin Dai, Wanyun Zhang, Yuxian Lai, Pei Zhang, Chunjiang Zhou, Yinuo Wang, Qingfeng Cao, Xiang Luo, Yujie Lai, Changwei Huang, Peizeng Yang   +12 more
wiley   +1 more source

AI Designed Conformation Locking Peptides Target STING to Restore Diabetic Wound Healing

Advanced Science, EarlyView.
A generative AI pipeline identifies SCP‐1, a conformation‐locking peptide that stabilizes inactive STING. Incorporated into a dual‐responsive hydrogel for localized, MMP‐9‐triggered release, SCP‐1 suppresses inflammation, promotes reparative macrophage polarization, and accelerates diabetic wound healing.
Xinyu Li, Haojie Fu, Zhe Wang, Xuanzhou Chen, Ruhong Zhang, Xudong Wang, Louis D. Zhang, Xiang Li, Datao Li   +8 more
wiley   +1 more source

The Electrogenic Na+/K+ Pump Is a Key Determinant of Repolarization Abnormality Susceptibility in Human Ventricular Cardiomyocytes: A Population-Based Simulation Study

Frontiers in Physiology, 2017
Background: Cellular repolarization abnormalities occur unpredictably due to disease and drug effects, and can occur even in cardiomyocytes that exhibit normal action potentials (AP) under control conditions.
Oliver J. Britton, Alfonso Bueno-Orovio, László Virág, András Varró, Blanca Rodriguez   +4 more
doaj   +1 more source

A meta-analysis of genome-wide association studies of the electrocardiographic early repolarization pattern

, 2012
BACKGROUND:: The early repolarization pattern (ERP) is common and associated with risk of sudden cardiac death. ERP is heritable and mutations have been described in syndromatic cases.
Wichmann, Heinz-Erich, Pietila, Arto, Wichmann, H. -Erich, F. M. Merchant, Hwang, Shih-Jen, Peloso, Gina, M. S. Nieminen, Kaeaeb, Stefan, L. Lyytikäinen, K. Silander, S. Hwang, C. Meisinger, M. A. Laaksonen, J. Tikkanen, Beckmann, Britt Maria, Havulinna, Aki S., Cooper, Rebecca R., M. J. Junttila, Huikuri, Heikki V., Merchant, Faisal M., Kahonen, Mika, A. Peters, C. J. O'Donnell, Salomaa, Veikko, T. Meitinger, Hengstenberg, Christian, R. R. Cooper, Lehtimaki, Terho, O'Donnell, Christopher J., Porthan, Kimmo, Gasparini, Paolo, Peters, Annette, Raitakari, Olli, M. Müller Nurasyid, Thorand, Barbara, J. Viikari, A. S. Havulinna, Oikarinen, Lasse, C. Hengstenberg, Nieminen, Markku S., Perz, Siegfried, P. Lichtner, H. V. Huikuri, W. Reinhard, Sinner, Moritz F., Noseworthy, Peter A., Ellinor, Patrick T., K. Porthan, B. Thorand, M. F. Sinner, Brockhaus, A. Catharina, Reinhard, Wibke, Mueller-Nurasyid, Martina, Kääb, Stefan, Sinagra, Gianfranco, Lichtner, Peter, H. Wichmann, L. Oikarinen, Laaksonen, Maarit A., B. M. Beckmann, T. Lehtimäki, S. Kääb, Meitinger, Thomas, G. Peloso, Silander, Kaisa, Newton-Cheh, Christopher, V. Salomaa, Junttila, M. Juhani, A. Iorio, P. A. Noseworthy, E. Martens, A. C. Brockhaus, M. Kähönen, Viikari, Jorma, N. Klopp, Lyytikainen, Leo-Pekka, Müller-Nurasyid, Martina, O. Raitakari, A. Pietilä, S. Perz, Martens, Eimo, Meisinger, Christa, P. T. Ellinor, Iorio, Annamaria, Ulivi, Sheila, C. Newton Cheh, S. Ulivi, Klopp, Norman, Tikkanen, Jani T., Wichmann, H.-Erich   +89 more
core   +1 more source