Results 121 to 130 of about 105,162 (327)

Thyroid hormones regulate cardiac repolarization and QT-interval related gene expression in hiPSC cardiomyocytes [PDF]

, 2022
Alessandra Ulivieri, Luca Lavra, Fiorenza Magi, Alessandra Morgante, Leonardo Calò, Patrizio Polisca, Leila Salehi, Salvatore Sciacchitano   +7 more
openalex   +1 more source

Engineering Osteoimmune Responses with Functionalized Orthopedic Implants for Post‐Operative Osteosarcoma Treatment

Advanced Science, EarlyView.
Osteosarcoma is the most common primary bone tumor with limited treatment options and a terrible prognosis. This review provides a comprehensive summary of the recent development of osteoimmunomodulatory implants for post‐operative osteosarcoma treatment, of which the potential utility in evoking durable anti‐osteosarcoma immunity and accelerating bone
Yilong Dong, Lingshuang Wang, Hui Zhang, Menghuan Li, Zhong Luo, Yan Hu, Chunyuan Cai   +6 more
wiley   +1 more source

Comparison of Paresthesia Mapping With Anatomic Placement in Burst Spinal Cord Stimulation: Long‐Term Results of the Prospective, Multicenter, Randomized, Double‐Blind, Crossover CRISP Study

Neuromodulation: Technology at the Neural Interface, EarlyView., 2021
Abstract Objectives Spinal cord stimulation (SCS) is an effective therapy for chronic intractable pain. Conventional SCS involves electrode placement based on intraoperative paresthesia mapping; however, newer paradigms like burst may allow for anatomic placement of leads.
Adnan Al‐Kaisy, Ganesan Baranidharan, Haggai Sharon, Stefano Palmisani, David Pang, Onita Will, Samuel Wesley, Tracey Crowther, Karl Ward, Paul Castino, Adil Raza, Yagna J. Pathak, Filippo Agnesi, Thomas Yearwood   +13 more
wiley   +1 more source

Autophagy‐Targeting Fe–Cu Nanozyme for Tumor Immune Microenvironment Remodeling and Image‐Guided Cancer Immunotherapy

Advanced Science, EarlyView.
In this study, a multifunctional iron‐copper metal–organic framework nanozyme platform co‐delivering chloroquine and perfluorohexane is engineered to circumvent tumor immune evasion by disrupting autophagic flux and restoring major histocompatibility complex class I presentation. This dual‐action nanoplatform orchestrates synergistic autophagy blockade
Li Yan, Chao Chen, Yu Liang, Xiaowan Huang, Jieying Qian, Hao Zhang, Li Zhang, Yingjia Li, Yunjiao Zhang   +8 more
wiley   +1 more source

Electrically Evoked Compound Action Potentials in Spinal Cord Stimulation: Implications for Preclinical Research Models

Neuromodulation: Technology at the Neural Interface, EarlyView., 2021
Abstract Objectives The study aimed to assess the feasibility of recording electrically evoked compound action potentials (ECAPs) from the rat spinal cord. To achieve this, we characterized electrophysiological responses of dorsal column (DC) axons from electrical stimulation and quantified the relationship between ECAP and motor thresholds (ECAPTs and
Birte Elisabeth Dietz, Dave Mugan, Quoc Chi Vuong, Ilona Obara   +3 more
wiley   +1 more source

Repolarization reserve, arrhythmia and new drug development

Acta Pharmaceutica Sinica B, 2013
Repolarization-related lethal arrhythmias have led to the concept of “repolarization reserve”, which may help elucidate the relationship between K+ currents and other components of repolarization.
Yang Li, Yicheng Fu
doaj   +1 more source

U wave: an Important Noninvasive Electrocardiographic Diagnostic Marker [PDF]

, 2005
Study of U waves exemplifies important clinical role of noninvasive electrocardiography in modern cardiology. Present article highlights significance of U waves with a clinical case and also summarizes in brief the history of the ...
Gupta, Mohit Dayal, MP, Girish, Mukhopadhyay, Saibal, TN, Sunil Roy, Trehan, Vijay, Yusuf, Jamal   +5 more
core   +2 more sources

Protection against severe hypokalemia but impaired cardiac repolarization after intense rowing exercise in healthy humans receiving salbutamol [PDF]

, 2018
Tania Atanasovska, Robert L. Smith, Claus Graff, Cao Thach Tran, Jacob Melgaard, Jørgen K. Kanters, Aaron C. Petersen, Antony Tobin, Keld Kjeldsen, Michael J. McKenna   +9 more
openalex   +1 more source

Bimetallic Nanozyme Amplifier for Synergistic Ferroptosis‐Cuproptosis and Metabolic Reprogramming to Reshape Immunosuppressive Tumor Microenvironment

Advanced Science, EarlyView.
The Bimetallic Nanozyme Amplifier (PEG@AuCZ@CC) to maximize hydrogen peroxide production and reprogram tumor metabolism from glycolysis to oxidative phosphorylation. This shift enhances ferroptotic/cuproptotic signaling cascades and creates a glucose‐enriched but lactate‐depleted tumor microenvironment (TME), effectively overcoming immune tolerance in ...
Jianzhang Luo, Kunzhao Huang, Xiaoyuan Yi, Pei Lu, Huaying Xie, Wen Li, Qingyu Zeng, Feifei He, Duo Wang, Liyan Wang   +9 more
wiley   +1 more source

Dispersion of atrial repolarization in patients with paroxysmal atrial fibrillation [PDF]

, 2001
Z Li, Eva Hertervig, Shiwen Yuan, Yan Yang, Zhengdao Lin, Bertil Olsson   +5 more
openalex   +1 more source