Results 141 to 150 of about 41,808 (246)

Persistent in vitro nociceptor hyperexcitability and axonal retraction produced by repeated paclitaxel doses

The FEBS Journal, EarlyView.
Repeated paclitaxel exposure causes long‐lasting nociceptor hyperexcitability and axonal retraction in adult sensory neurons. Using a long‐term primary nociceptor culture, we show that hyperexcitability is mediated by sequential upregulation of NaV1.8, TRPV1, TRPA1, and TRPM8 channels.
Angela Lamberti, Victor Moreno Lozano, Asia Fernández‐Carvajal, Antonio Ferrer‐Montiel   +3 more
wiley   +1 more source

Prognostic Value of Small Coved‐Type ST‐Segment Area in Patients With Spontaneous Type 1 Brugada Syndrome

Journal of Cardiovascular Electrophysiology, EarlyView.
Electrical and structural abnormalities in Brugada syndrome lead to a smaller coved‐type ST‐segment area. A reduced ST‐segment area may identify patients at elevated risk of ventricular fibrillation. ABSTRACT Background Risk stratification in Brugada syndrome (BrS) remains challenging.
Nario Sano, Tetsuji Shinohara, Keisuke Yonezu, Masaki Takahashi, Hirochika Yamasaki, Kei Hirota, Hidekazu Kondo, Akira Fukui, Hidefumi Akioka, Yasushi Teshima, Naohiko Takahashi   +10 more
wiley   +1 more source

From Whole Exome Sequencing to Patient‐Specific Therapy: Another Example of How Basic Research Pays Off in Patient Care

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2015
Arthur A. M. Wilde, Sami Viskin
doaj   +1 more source

Strategies for prolonging ventricular action potential duration without increasing transmural dispersion of repolarization. [PDF]

Physiol Rep
Cabo C.
europepmc   +1 more source

Arctic lake trout (Salvelinus namaycush) show evidence of seasonal acclimation of cardiac adrenergic sensitivity but not heat tolerance

Journal of Fish Biology, EarlyView.
Abstract Many Arctic fishes experience prolonged periods of extreme cold and large thermal variation over both rapid and seasonal time scales which challenge critical physiological functions. In the central Canadian Arctic, we caught wild adult lake trout (Salvelinus namaycush) acclimatized to winter and summer temperatures to determine the extent to ...
Emily P. Williams, Les N. Harris, Jean‐Sébastien Moore, Ella K. Middleton, Shira A. Berkelhammer, Ben Speers‐Roesch, Matthew J. H. Gilbert   +6 more
wiley   +1 more source

Effect of scar distribution on transmural and planar repolarization gradients and dispersion in non-ischemic cardiomyopathies with ventricular arrhythmias. [PDF]

Europace
Tonko JB, Cabrera-Borrego E, Sánchez-Millán P, Jiménez-Jáimez J, Chow A, Lambiase PD.   +5 more
europepmc   +1 more source

Evaluation and correlation of heart rate variability and ventricular repolarization parameters in an Indian pediatric clinical hypothyroid population: a prospective cohort study. [PDF]

Sci Rep
Dhakar D, Ahluwalia H, Meena KR, Tomar A.   +3 more
europepmc   +1 more source

Utilization and Prognosis of Cardiac Device Implantation in AL Versus ATTR Amyloidosis

Pacing and Clinical Electrophysiology, EarlyView.
ABSTRACT Introduction Cardiac amyloidosis can cause congestive heart failure, arrhythmias, and heart blocks, which frequently require cardiac device implantation (CDI). However, the differences between light chain (AL) amyloidosis and transthyretin (ATTR) amyloidosis CDI requirements are unknown. Methods A retrospective analysis was conducted using the
Bilal Hussain, Sanchit Duhan, Khawaja Hassan Akhtar, Amith Reddy Seri, Krittapoom Akrawinthawong, Janardhana Gorthi, Bijeta Keisham, Tarun Dasari   +7 more
wiley   +1 more source

Unique repolarization response after spontaneous nonsustained ventricular tachycardia. [PDF]

HeartRhythm Case Rep
Przybylski R, Roberts JD, Chen SRW, Held EP.   +3 more
europepmc   +1 more source

Isometric training at longer muscle–tendon complex lengths: A potential countermeasure to impaired neuro‐muscle–tendon function during space travel

Experimental Physiology, EarlyView.
Abstract Manned space exploration to distant destinations, including Mars, continues to be an aspiration of humankind. Space travel does, however, present many challenges to the body, amongst which adaptation to microgravity is perhaps the largest. For instance, both short and long manned spaceflight missions have shown substantial deleterious effects ...
Gerard McMahon, Andy Sanderson, Hans Degens   +2 more
wiley   +1 more source