Results 211 to 220 of about 57,164 (287)

Multi‐omics analysis of ion channels expressed by chicken embryo vestibular type I and type II hair cells

Experimental Physiology, EarlyView.
Abstract Balance and gaze rely on the rapid and accurate detection and signalling of head movements by vestibular type I and type II hair cells. Signal transduction and transmission involve several types of ion channels, which are acquired progressively during hair cell differentiation and whose identity is known only in part.
Giulia Cheli, Roberta Giunta, Francesca Stella, Eleonora Guidi, Umberto Laforenza, Mariarosa Polimeni, Giancarlo Russo, Francesca Borgo, Lazarevic Dejan, Sergio Masetto   +9 more
wiley   +1 more source

Cardiac Electrophysiologic Effects of Different Local Anesthetics in Langendorff-Perfused Rabbit Hearts. [PDF]

Cardiovasc Toxicol
Wolfes J, Katthöfer A, Wegner F, Rath B, Doldi F, Güler-Eren S, Eckardt L, Frommeyer G, Ellermann C.   +8 more
europepmc   +1 more source

Determining properties of human‐induced pluripotent stem cell‐derived cardiomyocytes using spatially resolved electromechanical metrics

The Journal of Physiology, EarlyView.
Abstract figure legend In this study, we use human‐induced pluripotent stem cell‐derived cardiomyocyte (hiPSC‐CM) experiments and computational modelling to identify the mechanism of action of drug compounds. In the hiPSC‐CM experiments, optical measurements of cell collections are recorded in the baseline case and after drug exposure.
Karoline Horgmo Jæger, Verena Charwat, Kevin E. Healy, Samuel Wall, Aslak Tveito   +4 more
wiley   +1 more source

Ventricular Repolarization Abnormalities in Pediatric Athletes: A Practical Approach to Clinical Evaluation. [PDF]

J Cardiovasc Dev Dis
Morra L, Borzuola R, Gianfelici A, Nifosì F, Quaranta F, Calò L, Pigozzi F, Fossati C.   +7 more
europepmc   +1 more source

In silico modelling of multi‐electrode arrays for enhancing cardiac drug testing on hiPSC‐CM heterogeneous tissues

The Journal of Physiology, EarlyView.
Abstract figure legend Schematic overview of the experimental and computational framework for investigating hiPSC‐CM electrophysiology with MEA systems. The MEA‐based model integrates experimental data with phenotype‐specific ionic models and tissue‐level heterogeneity.
Sofia Botti, Rolf Krause, Luca F. Pavarino   +2 more
wiley   +1 more source

An eikonal model with re‐excitability for fast simulations in cardiac electrophysiology

The Journal of Physiology, EarlyView.
Abstract figure legend Restitution properties obtained from cable‐equation simulations and anisotropic remeshing informed by local fibre orientation are combined in an eikonal model with re‐excitability. The resulting reduced electrophysiology model enables efficient simulations of recurrent activation patterns, here illustrated by atrial re‐entry ...
Lia Gander, Rolf Krause, Francisco Sahli Costabal, Simone Pezzuto   +3 more
wiley   +1 more source

Evaluation of Atrial and Ventricular Myocardial Repolarization Markers During Acute Migraine Attack. [PDF]

J Clin Med
Katırcı Y, Emektar E, Yıldırım M, Güler Ö, Korucu O, Yüzbaşıoğlu Y, Ensarioğlu M, Ceritoğlu SM, Küçük O, Aydemir S.   +9 more
europepmc   +1 more source

Mechanisms underlying local Ca2+ signalling differences between right and left atrial myocytes at normal and increased frequencies

The Journal of Physiology, EarlyView.
Abstract figure legend Left atrial myocytes have TAT‐associated faster Ca2+ release but are more prone to maladaptation at higher frequencies due to weaker peripheral SR Ca2+ uptake and smaller trigger Ca2+ current. Abstract Changes in heart rate affect Ca2+ signalling and contractility in ventricular muscle, but the effects on atrial Ca2+ signalling ...
Joon‐Chul Kim, Hieu Trong Huynh, Phuong Kim Luong, Tran Nguyet Trinh, Yixuan Wu, Eleonora Grandi, Sun‐Hee Woo   +6 more
wiley   +1 more source

Electrophysiological Changes in Children with Isolated Persistent Left Superior Vena Cava: A Case-Control Study. [PDF]

J Clin Med
Arici S, Surekli Karakus O, Yagar Keskin G, Tas E, Genc FA, Bayraktar S, Sungur M, Yildirim AI.   +7 more
europepmc   +1 more source

Deciphering pro‐arrhythmogenic mechanisms of EPAC in human atrial cardiomyocytes

The Journal of Physiology, EarlyView.
Abstract figure legend This study aimed to investigate the effect of exchange proteins directly activated by cAMP (EPAC) on the regulation of human atrial cardiomyocyte electrophysiology and their potential involvement in the onset of atrial fibrillation (AF).
Arthur Boileve, Margaux Aize, Maximin Détrait, Laura Brard, Adrien Leboyer, Pierre‐Antoine Dupont, Alexandre Lebrun, Vladimir Saplacan, Christophe Simard, Fabien Brette, Frank Lezoualc'h, Laurent Sallé   +11 more
wiley   +1 more source