Results 241 to 250 of about 100,632 (325)

Sympathetic activity-associated periodic repolarization dynamics predict mortality following myocardial infarction.

Journal of Clinical Investigation, 2014
K. Rizas, T. Nieminen, P. Barthel, C. Zürn, M. Kähönen, J. Viik, T. Lehtimäki, K. Nikus, C. Eick, T. Greiner, H. Wendel, P. Seizer, J. Schreieck, M. Gawaz, G. Schmidt, A. Bauer   +15 more
semanticscholar   +1 more source

Repolarization adaptation to rapid change in heart rate in human models – a review

The Journal of Physiology, EarlyView.
Abstract figure legend This review focuses on non‐invasive assessment of repolarization duration and dispersion (heterogeneity) adaptation to change in heart rate (HR). HR was increased incrementally by left atrial pacing during an electrophysiology (EP) study and by a bolus injection of atropine and in a step up/down fashion by repeated right atrial ...
Lennart Bergfeldt, Karl‐Jonas Axelsson, Pia Dahlberg, Farzad Vahedi, Gunilla Lundahl, Lennart Gransberg   +5 more
wiley   +1 more source

CineECG detects abnormal electrical activity in the 12-lead ECG of preclinical plakophilin-2 variant carriers. [PDF]

Heart Rhythm O2
van der Schaaf I, Kloosterman M, Gorgels APM, Te Riele ASJM, van Dam PM, Loh P.   +5 more
europepmc   +1 more source

Ether-a-go-go related gene-1a potassium channel abundance varies within specific skeletal muscle fiber type [PDF]

, 2019
Anderson, Luke B., Cobb, Brittan, Khader, Omar, Latour, Chase D., Massey, Bryce H., Pond, Amber L.   +5 more
core   +1 more source

Computational modelling of the pro‐ and antiarrhythmic effects of atrial high rate‐dependent trafficking of small‐conductance calcium‐activated potassium channels

The Journal of Physiology, EarlyView.
Abstract figure legend Small‐conductance calcium‐activated potassium (SK) channels are important for atrial repolarization and can be targeted for atrial‐specific antiarrhythmic treatments. We developed a computational model with a calcium sensor to study the effects of increased pacing rate (5 Hz), which enhances SK‐channel gating and forward ...
Stefan Meier, Dobromir Dobrev, Paul G. A. Volders, Jordi Heijman   +3 more
wiley   +1 more source

Oxaliplatin and amlodipine combination induced reversible Brugada phenocopy: A case report. [PDF]

Medicine (Baltimore)
Bian W, Zhang H, Liu M, Qi X, Li J.
europepmc   +1 more source

In silico predictions of action potential propagation in doxorubicin cardiotoxicity: A parametric study using preclinical 3D magnetic resonance imaging‐based fibrotic left ventricle models

The Journal of Physiology, EarlyView.
Abstract figure legend Schematic overview of the study's methodology and key findings. In a preclinical swine model, doxorubicin administration induced cardiotoxicity, characterized by diffuse fibrotic remodelling and altered electrical function, as assessed by magnetic resonance (MR) imaging and electrophysiological mapping.
Javier Villar‐Valero, Jairo Rodríguez Padilla, Nicolas Cedilnik, Buntheng Ly, Juan F. Gomez, Maxime Sermesant, Mihaela Pop, Beatriz Trenor   +7 more
wiley   +1 more source

Piezo1-mediated neuroexcitation via collaboration with KCa1.1 and Nav1.9 currents in myelinated Ah-type of trigeminal ganglion neurons in rats: Mechanistic insights with sex-specific effects. [PDF]

Mol Pain
Liu Y, Song Y, Ren X, Li M, Liu S, Li Z, Ding D, Lu X.   +7 more
europepmc   +1 more source

Deciphering pro‐arrhythmogenic mechanisms of EPAC in human atrial cardiomyocytes

The Journal of Physiology, EarlyView.
Abstract figure legend This study aimed to investigate the effect of exchange proteins directly activated by cAMP (EPAC) on the regulation of human atrial cardiomyocyte electrophysiology and their potential involvement in the onset of atrial fibrillation (AF).
Arthur Boileve, Margaux Aize, Maximin Détrait, Laura Brard, Adrien Leboyer, Pierre‐Antoine Dupont, Alexandre Lebrun, Vladimir Saplacan, Christophe Simard, Fabien Brette, Frank Lezoualc'h, Laurent Sallé   +11 more
wiley   +1 more source

AAV9-mediated KCNH2 suppression-replacement gene therapy in a transgenic rabbit model of type 1 short QT syndrome. [PDF]

Eur Heart J
Nimani S, Bains S, Alerni N, Ördög B, Horváth A, Matas L, Louradour J, Giammarino L, Tester DJ, Beslac O, Lopez R, Meier S, Egle M, Christoforou N, Barbieri M, Vashanthakumar V, Perez-Feliz S, Parodi C, Garcia Casalta LG, Kim CSJ, Zhou W, Ye D, Jurgensen J, Barry MA, Bego M, Keyes L, Owens J, Pinkstaff J, Christoph J, Zehender M, Brunner M, Heijman J, Casoni D, Praz F, Haeberlin A, Brooks G, Ackerman MJ, Odening KE.   +37 more
europepmc   +1 more source