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In this study, we investigated the validity of T wave area-based parameters for the identification of drug-induced changes of repolarization. Based on electrocardiograms from 39 healthy patients, we computed the stability of repolarization measurements ...
Börje Darpo, Jean-Philippe Couderc
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Genetics of cardiac repolarization
Nature Genetics, 2009Prolongation of the electrocardiographic QT interval, a measure of cardiac repolarization, is associated with arrhythmogenic disorders and is a risk factor for sudden cardiac death. Two genome-wide association studies (GWAS) of variation in the QT interval in population-based cohorts now report association with variants in a subset of ion channel genes
Svati H, Shah, Geoffrey S, Pitt
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Delayed repolarization syndrome
The American Journal of Medicine, 1983The electrocardiograms of 18 patients with atypical ventricular tachycardia manifested as torsade de pointes, ventricular fibrillo-flutter, polymorphous ventricular tachycardia, and uniform ventricular tachycardia were analyzed. The patients were divided into two groups: The first group included 10 patients with prolonged Q-T intervals or abnormal U ...
P, Schweitzer, H, Mark
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Malignant Early Repolarization
The American Journal of Cardiology, 2018A 27-year-old man presents with successfully resuscitated ventricular fibrillation. Structural and electrical causes of ventricular fibrillation in the young are presented along with a diagnostic strategy. Electrocardiographic features of malignant early repolarization are discussed.
Elias B, Hanna +4 more
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Cardiac Electrophysiology Clinics, 2010
Sudden cardiac death (SCD) is defined as an unexpected natural death from a cardiac cause within a short time period, generally less than or equal to 1 hour from the onset of symptoms, in a person without any prior condition that seems to result in instantaneous fatality.
Ashok J, Shah +16 more
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Sudden cardiac death (SCD) is defined as an unexpected natural death from a cardiac cause within a short time period, generally less than or equal to 1 hour from the onset of symptoms, in a person without any prior condition that seems to result in instantaneous fatality.
Ashok J, Shah +16 more
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Repolarization of Hepatocytes in Culture
Hepatology, 1997We have evaluated the biochemical, morphological, and functional redevelopment of polarity in freshly isolated hepatocytes cultured using a double layer collagen gel sandwich technique. Western blot analysis showed increased cellular levels of the cell adhesion protein uvomorulin as cultured ...
M A, Talamini, B, Kappus, A, Hubbard
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The early repolarization syndrome
The Journal of Emergency Medicine, 1989The syndrome of the early repolarization variant is described. This benign ECG phenomenon is noted in 1% to 2% of the adult population and generally occurs in the absence of myocardial disease. The ECG manifestations may mimic acute myocardial injury or pericarditis. Exercise and isoproterenol tend to normalize the RST segment elevation.
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Repolarization Abnormalities in the Newborn
Journal of Cardiovascular Pharmacology, 2010The recognition of ventricular repolarization abnormalities in the newborn carries several and significant implications, because it calls attention to the possibility of dealing with an infant affected by the long QT syndrome (LQTS). This article provides key elements for the correct measurement of the QT interval in newborns and succinctly reviews ...
SCHWARTZ, PETER, Stramba Badiale M.
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Impaired Ventricular Repolarization Dynamics in Patients with Early Repolarization Syndrome
Journal of Cardiovascular Electrophysiology, 2013QT Dynamics in Early Repolarization SyndromeIntroductionAlmost all current investigations on early repolarization syndrome (ERS) have focused on the J‐wave characteristics and ST‐segment configuration; however, few have reported on ventricular repolarization indexes in ERS.Methods and ResultsA total of 145 subjects were enrolled: 10 ERS patients, 45 ...
Ahmed Karim, Talib +12 more
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Mechanisms and control of repolarization
European Heart Journal, 1993This paper describes and discusses interventions that may lead to prolongation of the action potential. Special emphasis is given to regulation by drugs. The results of studies focusing on the modulation of inward and outward currents are presented in detail. Specific attention is given to Na+, Ca2+, K+ and Cl- channel currents and their components.
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