Results 291 to 300 of about 105,162 (327)

Reduced osmoresponsiveness in magnocellular neuroendocrine neurones during chronic salt‐loading

The Journal of Physiology, EarlyView.
Abstract figure legend We conducted a large systematic survey of the physiological and electrophysiological characteristics of the magnocellular neurosecretory neurones of the supraoptic nucleus in euhydrated and salt‐loaded conditions. Our in vivo electrophysiological recordings show that, after 7 days of salt‐loading, the neuronal responsiveness to ...
Maja Lozic, Roongrit Klinjampa, Nancy Sabatier, Duncan J. MacGregor, Gareth Leng, Mike Ludwig   +5 more
wiley   +1 more source

Adenosine and acute low oxygen conditions suppress urinary bladder contractility through the activation of adenosine 2B receptors and large‐conductance calcium‐activated potassium channels

The Journal of Physiology, EarlyView.
Abstract figure legend Detrusor smooth muscle surrounding the urinary bladder produces transient pressure events essential for sensing bladder fullness during the filling phase. We investigated the role of adenosine, a ubiquitous signalling molecule, in regulating bladder smooth muscle function.
Gerald M. Herrera, Jason L. Rengo, Grant W. Hennig, Thomas J. Heppner, Alexandria M. Hepp, Maria Sancho, Saul Huerta de la Cruz, Mark T. Nelson, Nicholas R. Klug   +8 more
wiley   +1 more source

Brugada syndrome, early repolarization syndrome/j-wave syndromes, and a subtype of idiopathic ventricular fibrillation: microstructural cardiomyopathies

Andrés Ricardo Pérez‐Riera, Kjell Nikus, Adrián Baranchuk, Pedro Brugada   +3 more
openalex   +1 more source

Mechanistic insights into sex differences in atrial electrophysiology and arrhythmia vulnerability through sex‐specific computational models

The Journal of Physiology, EarlyView.
Abstract figure legend Sex‐specific models of the human atrial myocyte in normal sinus rhythm (nSR) and chronic atrial fibrillation (cAF) revealed increased alternans susceptibility in cAF males and DADs in females, driven primarily by ICaL and ryanodine receptor remodelling.
Nathaniel T. Herrera, Haibo Ni, Charlotte E. R. Smith, Yixuan Wu, Dobromir Dobrev, Stefano Morotti, Eleonora Grandi   +6 more
wiley   +1 more source

Dextrocardia as an uncommon cause of inferior ST-segment elevation. [PDF]

Arch Clin Cases
Ballesteros RV, García-Bello E, Zulet P.   +2 more
europepmc   +1 more source

Cardiac Electrophysiological Effects of the Sodium Channel-Blocking Antiepileptic Drugs Lamotrigine and Lacosamide. [PDF]

Pharmaceuticals (Basel)
Wolfes J, Achenbach P, Wegner FK, Rath B, Eckardt L, Frommeyer G, Ellermann C.   +6 more
europepmc   +1 more source

Exonic Variation and Its Clinical Impact in 7221 Old Order Amish

American Journal of Medical Genetics Part A, Volume 197, Issue 12, December 2025.
ABSTRACT The Amish of Lancaster County, PA has been the focus of genetic studies for many years due to its demographic history and unique genetic makeup that includes a historical bottleneck event and subsequent genetic drift, resulting in a marked decrease in genetic diversity and increased frequency of some variants that have substantially shaped the
Braxton D. Mitchell, Ebuka Onyenobi, Joshua P. Lewis, Brady Gaynor, James A. Perry, Kristin Maloney, Jeffrey R. O'Connell, Jessica Tiner, Amber L. Beitelshees, Cristopher V. Van Hout, Patrick F. McArdle, Huichun Xu, Erik G. Puffenberger, Karlla W. Brigatti, Melanie Daue, Hilary B. Whitlatch, Anna Alkelai, Alejandro A. Schäffer, John Overton, Elizabeth A. Streeten, Toni I. Pollin, Alan R. Shuldiner   +21 more
wiley   +1 more source

Mitochondrial Dysfunction Contributes to Decompensation in a Zebrafish Model of Isoproterenol‐Induced Heart Failure

Acta Physiologica, Volume 241, Issue 12, December 2025.
ABSTRACT Aim Heart failure is a clinical syndrome where the heart's structural or functional impairment leads to inadequate blood flow to meet the body's metabolic demands. Mitochondrial dysfunction is increasingly recognized as a central contributor underlying the contractile impairment observed in the failing heart.
Manuel Vicente, Aaron García‐Blázquez, Antonio Martínez‐Sielva, Jussep Salgado‐Almario, Joaquín Jordán, Beatriz Domingo, Juan Llopis   +6 more
wiley   +1 more source

Mavacamten for treatment of symptomatic mid-ventricular obstruction in hypertrophic cardiomyopathy: a case report. [PDF]

Eur Heart J Case Rep
Hunziker S, Haaf P, Vischer AS.
europepmc   +1 more source

Nanoshield‐Assisted Viral Gene Therapy with Induction of Non‐Apoptotic Cell Death and Durable Antitumor Immunity

Advanced Science, Volume 12, Issue 41, November 6, 2025.
A novel hybrid gene delivery platform combines adeno‐associated virus (AAV)‐mediated receptor‐interacting kinase 3 (RIPK3) expression with manganese dioxide‐polyethyleneimine (MnO2−PEI) nanoshield to induce necroptosis, ferroptosis, and immunogenic cell death, effectively reprogramming the tumor microenvironment.
Soo‐Hwan Lee, Yunkyeong Cho, Seunghwan Bang, Daeun Sung, Jahyun Koo, Seoyoung Kim, Youngil Koh, Hojun Kim, Hyojin Lee   +8 more
wiley   +1 more source